Origen, on John 11:54

“Wherefore Jesus walked no more openly among the Jews; but he went into a country near the desert, unto a city that is called Ephrem, and there he abode with his disciples.”

“(t. xxviii. c. 19.) Mystically, Jesus walked openly among the Jews, when the Word of God used to come to them by the Prophets. But this Word ceased, i. e. Jesus went thence. (Is. 54:1) And He went to that town near the wilderness, whereof Isaiah says, More are the children of the desolate, than the children of the married wife. Ephraim signifies fertility. Ephraim was the younger brother of Manasses: Manasses stands for the elder people forgotten; the word Manasses meaning forgotten. When the elder people were forgotten and passed over, there came an abundant harvest from the Gentiles. Our Lord left the Jews, and went forth into a country—the whole world—near the wilderness, the deserted Church1, to Ephraim, the fruitful city; and there continues with His disciples up to this day.”

Imported from an open dataset — not yet checked against the printed edition.