The interpretation timeline
2 Timothy 2:17 Douay-Rheims

And their speech spreadeth like a canker: of whom are Hymeneus and Philetus:

A.D. 202 – 1871 13 witnesses 14 excerpts

Patristic

before A.D. 750
202
A.D.
Irenaeus Patristic
c. A.D. 130–202
“Moreover, those also will be thus confuted who belong to Simon and Carpocrates, and if there be any others who are said to perform miracles—who do not perform what they do either through the power of God, or in connection with the truth, nor for the well-being of men, but for the sake of destroying and misleading mankind, by means of magical deceptions, and with universal deceit, thus entailing greater harm than good on those who believe them, with respect to the point on which they lead them astray. For they can neither confer sight on the blind, nor hearing on the deaf, nor chase away all sorts of demons—none, indeed, except those that are sent into others by themselves, if they can even do so much as this. Nor can they cure the weak, or the lame, or the paralytic, or those who are distressed in any other part of the body, as has often been done in regard to bodily infirmity. Nor can they furnish effective remedies for those external accidents which may occur. And so far are they from being able to raise the dead, as the Lord raised them, and the apostles did by means of prayer, and as has been frequently done in the brotherhood on account of some necessity—the entire Church in that particular locality entreating the boon with much fasting and prayer, the spirit of the dead man has returned, and he has been bestowed in answer to the prayers of the saints—that they do not even believe this can possibly be done, and hold that the resurrection from the dead is simply an acquaintance with that truth which they proclaim.”
Source
220
A.D.
Tertullian Patristic
c. A.D. 150–220
“It is a comparatively small thing, that certain men, like Phygellus, and Hermogenes, and Philetus, and Hymenµus, deserted His apostle: the betrayer of Christ was himself one of the apostles. Unhappy Aristotle! who invented for these men dialectics, the art of building up and pulling down; an art so evasive in its propositions, so far-fetched in its conjectures, so harsh, in its arguments, so productive of contentions-embarrassing even to itself, retracting everything, and really treating of nothing! Whence spring those "fables and endless genealogies," and "unprofitable questions," and "words which spread like a cancer? " From all these, when the apostle would restrain us, he expressly names philosophy as that which he would have us be on our guard against.”
Source
258
A.D.
Cyprian Patristic
c. A.D. 200–258
“But if we consider what the apostles thought about heretics, we shall find that they, in all their epistles, execrated and detested the sacrilegious wickedness of heretics. For when they say that "their word creeps as a canker". Flee from such men as much as you can; avoid with a wholesome caution those who adhere to their mischievous contact. Their word doth eat as doth a cancer;. Also in the second to Timothy: "Their word doth creep as a canker."”
Source
“From such men come those who, without divine appointment, set themselves over their rash associates, make themselves prelates without any lawful ordination and call themselves bishops though no one gives them a bishopric. The Holy Spirit portrays them in the Psalms "sitting in the seat of pestilence," plagues and blights to faith, snake-mouthed traitors, scheming to pervert truth, spewing deadly poisons from their pestiferous tongues. Their words "spread like a canker." Their teaching pours fatal venom into men's hearts and breasts.”
Source
326
A.D.
c. A.D. 250–326
“But these by all their words have attempted to do away with the Godhead of Christ, have made those seem righteous, since they have come nearer to Antichrist. Wherefore they have been excommunicated and anathematized by the Church. And indeed, although we grieve at the destruction of these men, especially that after having once learned the doctrine of the Church, they have now gone back; yet we do not wonder at it; for this very thing Hymenaeus and Philetus suffered, and before them Judas, who, though he followed the Saviour, afterwards became a traitor and an apostate.”
Source
373
A.D.
c. A.D. 296–373
“And what they now write proceeds not from any regard for the truth, as I said before, but rather they do it as in mockery and by a subterfuge, for the purpose of deceiving others. They hope that by sending about their letters they may engage the ears of the people to listen to these notions and so put off the time when they will be brought to trial. By concealing their impiety from observation, they try to make room to extend their heresy, which, "like a gangrene," eats its way everywhere.”
Source
379
A.D.
Basil of Caesarea Patristic
c. A.D. 330–379
“"Let the wickedness of sinners be brought to nought." He who says this prayer is obviously a disciple of the evangelical precepts. He prays for those who treat him maliciously, asking that the wickedness of the sinners be circumscribed by a definite limit and boundary. Just as if someone, when praying for those who are suffering in body, would say, "Let the disease of those who are suffering come to an end." In order that the sin slowly creeping farther may not spread like cancer, since he loves his enemy and wishes to do good to those who hate him, and for this reason prays for those who treat him maliciously, he begs of God that the further outpouring of sin may cease and have definite bounds.”
Source
407
A.D.
John Chrysostom Patristic
A.D. 347–407
“"And shun profane novelties of speech." For they will not stop there. For when anything new has been introduced, it is ever producing innovations, and the error of him who has once left the safe harbor is infinite, and never stops. "For they will increase unto more ungodliness," he says, "And their word will eat as doth a canker." It is an evil not to be restrained, not curable by any medicine, it destroys the whole frame. He shows that novelty of doctrine is a disease, and worse than a disease. And here he implies that they are incorrigible, and that they erred not weakly but willfully.”
Source
461
A.D.
Leo the Great Patristic
c. A.D. 400–461
“To deceive the first human beings, the devil claimed the serpent as his tool. So to seduce the hearts of orthodox, he armed the tongues of these with the poison of his falsehood. With pastoral care, however, we oppose these snares, dearly beloved, to the extent that the Lord helps us. To prevent any of the holy flock from perishing, we advise you with fatherly admonitions to turn away from "wicked lips and treacherous tongue," from which the prophet asks that his soul "be kept free," since "their talk crawls like a crab," as the blessed apostle said. They creep in low to the ground, take hold softly, squeeze gently and kill undetected.”
Source

Scholastic

c. 1100 – 1500
1273
A.D.
Thomas Aquinas Catholic
1225–1274
“Above he instructed Timothy, showing the general manner by which unbelievers are to be resisted; here he shows in particular the things which are to be resisted. And first he shows the things which are to be resisted; second, why, at "for they profit much"; third, how, at "youthful." He says therefore, "avoid profane things and vain talk." Here he shows that two things are to be avoided, namely profane things and vain talk, and these refer either to the same thing or to different things. For "profane" things are so called as if far from the shrine, that is, from divine worship, and these are the teachings of heresies; and these are to be avoided, therefore he says "avoid profane things." It can also be said that these "profane" things are those which are contrary to the faith, while "vain talk" is fable-like things. Ps. 11:3: "each one has spoken vain things to his neighbor." Then when he says "for they profit much," he shows why these are to be avoided, and this in two ways. First from the harm which they inflict; second from the fruit of avoiding them, at "if anyone." Concerning the first he does two things, because first he shows how they harm unto the subversion of the faith; second, how they cannot totally subvert the faith, at "but the firm." Likewise, first he sets down the teaching; second he adds a comparison, at "and the word"; third an example, at "of whom is." He says therefore: these things are to be avoided which hinder piety, which is called the worship of God. Hence the doctrine of faith is the doctrine of piety. But impiety is a doctrine against the faith; hence he says "for they profit much unto impiety," that is, they lead to error or to erroneous doctrine. But here "profit" is used, with regard to evils, in an abusive sense. Below 3:13: "evil men and seducers profit unto the worse, erring and sending others into error." Then he sets down a comparison for them, saying "word." For heretics say from the beginning certain true and useful things, but when they are heard, they mix in certain things, which they spew forth, deadly things. And therefore he says "their word," et cetera. Ecclus. 11:34: "from one spark a fire is increased, and from one deceitful man blood is increased." Then when he says "of whom," he sets down an example for this. For these two, in their time, were corrupting the faith. By whom certain ones, erring, were turned to vain talk, et cetera. Concerning Philetus it is said above at 1:15: "all who are in Asia have turned away from me, of whom are Philetus and Hermogenes." But concerning Hymenaeus it is found in 1 Tim. 1:20: "of whom is Hymenaeus." And he says "they have fallen away." 1 John 2:19: "they went out from us." And this aggravates the matter, because 2 Peter 2:21: "for it would have been better for them not to have known the way of righteousness, than after the knowledge of it to turn back." But they were erring, saying that the resurrection had already taken place. Concerning which, Matt. 27:52: "many bodies of the saints who had slept arose." And they said that there is no other resurrection to be expected, but that they rose then. In another and better way, they said that just as there is a twofold death, so there is a twofold resurrection, namely of the soul and of the body. Concerning the resurrection of the soul it is found in Apoc. 20:6: "blessed and holy is he who has a part in the first resurrection." They said therefore that all things which are said in the Scriptures were to be referred to the resurrection of souls, which has already taken place. Col. 3:1: "if you have risen with Christ, seek the things that are above." And this error exists even today among heretics, and through it they subvert certain people. And fittingly he says "and they have subverted the faith of some," because they destroy the foundation of the faith. Acts 13:10: "O full of all deceit and all cunning, son of the Devil, and enemy of all justice, you do not cease to subvert the right ways of the Lord." Then when he says "but the firm," he shows how the faith is not to be totally subverted through heresies. And first, that through heretical doctrines the whole faith of the Church cannot be corrupted; second he shows why God permits some to err, at "but in a great [house]." Likewise, first he shows the immovability of the faith of the elect; second he adds a demonstration, at "having." He says therefore: they subvert, "but the firm foundation of God stands." For these foundations are those to which the grace of standing immovably is given. Matt. 7:25: "for it was founded upon a firm rock." "Firm," because immovable. Hence it is stated beforehand there at Matt. 7:25, that "the floods came, and the winds blew, and they rushed upon that house, and it did not fall." The firmness of this depends first on divine predestination; second on our free will. And therefore, as to the first, he says: this firm foundation, "having this seal," that is, this is the sign of this firmness. John 3:33: "but he who has received his testimony has sealed that God is true." This is the first part of the seal, namely from divine predestination, "for the Lord knows who are his." And this is the knowledge of divine predestination. John 10:14: "I know my sheep, and I have other sheep, which are not of this fold." Matt. 7:23: "I do not know you." But as to the second he says, "let everyone depart from iniquity who calls upon..." As if to say: if they are predestined by God, it is that through free will they will be saved, because from this — that someone does not finally adhere to sin — he shows himself to be predestined. And he sets down two things, which pertain to the ordination in the state of salvation. The first, that he confess the faith; therefore he says "everyone who," et cetera. Rom. 10:10: "but with the mouth confession is made unto salvation." The second, that he withdraw from sin. Matt. 7:21: "not everyone who says to me, 'Lord, Lord,' shall enter the kingdom of heaven," et cetera. And therefore he says "let him depart," et cetera. Isa. 55:7: "let the wicked man forsake his way," et cetera. But as to what he says, "calls upon the name," he does not mean that he only names it with the mouth, but inwardly through faith, and outwardly through work. Then when he says "in a great," he sets down the reason why God permits some to err, although he loves all. But this can be understood in two ways, because either in general, or in particular with regard to this one or that one. For if you ask, in a particular case, why he gives to this one the gift of perseverance and not to that one, it has no reason except the will of God alone. Augustine: "why he draws this one, and does not draw that one, do not wish to judge, if you do not wish to err," et cetera. But if you ask in general why he gives to some, and to some not, it has a reason, which the Apostle assigns at Rom. 9:16. And it is the same reason as this one, although through other examples. For therefore he says: "he endured with much patience," et cetera. For according as all the works which God makes in nature and grace are made in order to manifest the glory of God — Ecclus. 42:16: "his work is full of the glory of the Lord" — so also he made diverse creatures, so that the perfection of divine goodness, which cannot be manifested through one, might be sufficiently manifested through another. So also it must be considered concerning one craftsman: in one house there is one window, which is more beautiful than another. If then someone should ask why the whole house is not a window, the reason is that the whole house would be imperfect. Similarly the Apostle says at 1 Cor. 12:17: "if the whole body were an eye, where would the hearing be?" So therefore the Apostle says, in the effect of grace, that it was fitting that God should manifest justice and mercy. For if he saved all, there would be only his mercy; if he damned all, there would be only justice. And therefore, "God willing to manifest wrath," that is, justice, et cetera. And the reason is similar concerning the perfection of the Church, which had to be perfect, that there might not be diversity in it. In which there is a threefold diversity, namely of the good and the evil, of the good and the better, of the evil and the worse. And assigning this he says, "but in a great house," that is, the Church — Bar. 3:24: "O Israel, how great is the house of God, and how vast is the place of his possession" — "there are not only vessels of gold," etc., where the golden and silver are distinguished from the earthen; likewise the silver from the golden; likewise the earthen from the wooden. In the first, a comparison of the good and the evil is implied; in the second, a comparison of the good and the better; in the third, of the evil and the worse. For the golden and silver are the good; but the golden are the better, the silver less good. Similarly the wooden and the earthen are the evil; but the earthen are the worse, while the wooden are less evil. Consequently he designates a diversity as to use, so that the good may be vessels "unto honor," as ones appointed for honorable use; but the evil may be earthen and wooden vessels, as ones appointed "unto dishonor," that is, for base use. For just as among men, certain ones, namely the saints, are as it were precious vessels. Ecclus. 50:10: "a solid vessel of gold," et cetera. Acts 9:15: "this man is a vessel of election to me," et cetera. But some are like useless vessels, namely the evil. Isa. 32:7: "the vessels of the deceitful are most evil." Ecclus. 21:17: "the heart of a fool is like a broken vessel." The first vessels are "unto honor," to which eternal life is owed. Rom. 2:7: "to those indeed who according to the patience of good work seek glory and honor and incorruption, eternal life." The second vessels are "unto dishonor." 1 Kings 2:30: "but those who despise me shall be ignoble." And the aforesaid diversity can otherwise be applied to the diversity of the Church, so that the golden vessels may be the prelates, but the silver, and the wooden, and the earthen may be those holding a lower rank, among whom there is a certain gradation. And what he adds, "some unto honor," etc., is then not to be understood as meaning that all the golden and silver vessels are unto honor, and the earthen unto dishonor, since from whatever state some are saved, and some are damned.”

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“And their word will eat as doth a cancer,.... Or "gangrene", which gnaws and feeds upon the flesh, inflames and mortifies as it goes, and spreads swiftly, and endangers the whole body; and is therefore to be speedily taken notice of, and stopped. It is better rendered "gangrene", as in the marginal reading, than "cancer". "The word "gangrene" is Greek (g), and is derived by some authors from the Paphlagonian "gangra", a goat; it being the character of a goat to browse the grass all around without shifting. It is more correct, perhaps, to derive it from the Greek word "manduco", "consumo", I eat, I consume. The "gangrene" is a disease in the flesh of the part which it corrupts, consumes, and turns black, spreading and seizing itself of the adjoining parts, and is rarely cured without amputation. By the microscope, a gangrene has been discovered to contain an infinite number of little worms engendered in the morbid flesh; and which continually producing new broods, they swarm, and overrun the adjacent parts: if the gangrene proceed to an utter sphacelation (or mortification), and be seated in any of the limbs, or extreme parts, recourse must be had to the operation of amputation'' And so the errors and heresies of false teachers worm and spread, and feed upon the souls of men, and eat up the vitals of religion, or what seemed to be such, and even destroy the very form of godliness; and bring destruction and death, wherever they come; and when they get into Christian churches, threaten the ruin of them; and therefore are to be opposed in time, and those infected with them to be cut off. Of whom is Hymenaeus and Philetus; these were some of the principal among the false teachers, the chief authors and spreaders of error and heresy: the former of these is mentioned before in Ti1 1:20 along with Alexander, as guilty of blasphemy, and as delivered up to Satan for it. Philetus is a Greek name as well as the other, though it is sometimes found in Roman inscriptions (h): it is very likely that these were both in Asia, and probably in Ephesus, or near to it, since the apostle mentions them by name to Timothy, that he might beware of them. (g) See Chambers's Cyclopedia in the word "Gangrene". (h) Vid. Kirchman. de Funer. Roman. l. 3. c. 10. p. 390.”
Source
1832
A.D.
Adam Clarke Methodist
1762–1832
“Their word will eat as doth a canker - Ὡς γαγγραινα· As a gangrene; i.e. as a mortification in the flesh, where the circulation is entirely stopped, and putrefaction takes place, which continues to corrupt all the circumjacent flesh, spreading more and more till death takes place, unless stopped by a timely and judicious application of medicine. Such is the influence of false doctrine; it fixes its mortal seed in the soul, which continues to corrupt and assimilate every thing to itself, till, if not prevented by a timely application of the word of life, under the direction of the heavenly Physician, it terminates in the bitter pains of an eternal death. To such a gangrene the apostle compares the corrupt doctrines of Hymeneus and Philetus.”
Source
1849
A.D.
1774–1849
“Like a cancer; [8] others say a canker or gangrene, a distempter that eats the flesh and parts affected. (Witham)”
1871
A.D.
1871
“will eat--literally, "will have pasture." The consuming progress of mortification is the image. They pretend to give rich spiritual pasture to their disciples: the only pasture is that of a spiritual cancer feeding on their vitals. canker--a "cancer" or "gangrene." Hymenaeus--(See on Ti1 1:20). After his excommunication he seems to have been readmitted into the Church and again to have troubled it.”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.