Isa 21:7

“[Daniel 5:1] "Belshazzar the king made a great feast for his one thousand nobles; and each one drank in the order of his age." It should be known that this man was not the son of Nebuchadnezzar, as readers commonly imagine; but according to Berosus, who wrote the history of the Chaldeans, and also Josephus, who follows Berosus, after Nebuchadnezzar's reign of forty-three years, a son named Evilmerodach succeeded to his throne. It was concerning this king that Jeremiah wrote that in the first year of his reign he raised the head of Jehoiachin, king of Judah, and took him out of his prison (Jeremiah 52:31). Josephus likewise reports that after the death of Evilmerodach, his son Neriglissar succeeded to his father's throne; after whom in turn came his son Labosordach. Upon the latter's death, his son, Belshazzar, obtained the kingdom, and it is of him that the Scripture now makes mention. After he had been killed by Darius, King of the Medes, who was the maternal uncle of Cyrus, King of the Persians, the empire of the Chaldeans was destroyed by Cyrus the Persian. It was these two kingdoms which Isaiah in chap. 21 (Isaiah 21:7) addresses as a charioteer of a vehicle drawn by a camel and an ass. Indeed Xenophon also writes the same thing in connection with the childhood of Cyrus the Great; likewise Pompeius Trogus and many others who have written up the history of the barbarians. Some authorities think that this Darius was the Astyages mentioned in the Greek writings, while others think it was Astyages' son, and that he was called by the other name among the barbarians. "And each one of the princes who had been invited drank in the order of his own age." Or else, as other translators have rendered it: "The king himself was drinking in the presence of all the princes whom he had invited."”

“(Verse 7.) And he saw a chariot with two horsemen, a rider on a donkey, and a rider on a camel. When I placed him on the watchtower, he saw a chariot coming with two horses, and a charioteer high above, and an ass and a camel drawing the chariot. But it signifies Cyrus, the king of the Persians and Medes, coming with little and great authority. For the Persians were formerly unknown before Cyrus and held no place among the nations; the Medes, however, were always very powerful. Therefore, this one, supported by the army of two nations, came against Babylon.”

“[In the Gospels it is said,] "And he began to send them forth two by two." He sent them two by two that no one of them, being abandoned and alone, might fall into a denial, like Peter, or flee, like John. Human frailty quickly falls if it proudly relies on itself, despises companions and is unwilling to have a colleague. As Scripture says, "Woe to him that is alone, for when he falls, he has none to lift him up." The same Scripture testifies how much one is strengthened by another's aid, when it states, "A brother that is helped by his brother is like a strong city."… This was done also to fulfill the prophecy of Isaiah, who testified that he had seen a rider of a two-horse chariot, when he heard it said to him, "What do you see?" And he replied, "I see a rider of a two-horse chariot." Because of this he cried out right away that Babylon had fallen, and all its graven gods. Who doubts, brothers, that by this two-horse chariot Christ was riding upon his saving journeys, since he sees that through the apostles' preaching temples have fallen, idols have perished, the bleating of herds has ceased and the victims, along with even the very altars with their perfume of incense, have already disappeared through all the centuries.”

“516. Second, the vision is set out, and first, he sets out the thing that was seen: and he saw a chariot with two horsemen, which was usually pulled by two horses, signifying the army of two kingdoms; a rider, namely of chariots, upon an ass, the kingdom of the Persians, which formerly was ignoble, a camel, the kingdom of the Medes, which was always lofty: as if these two animals were yoked together to a chariot in the place of two horses. Second, the diligence of the one who sees: and he beheld them diligently: set your heart upon all that I shall show you (Ezek 40:4).”