The interpretation timeline
Isaiah 55:10 Douay-Rheims

And as the rain and the snow come down from heaven, and return no more thither, but soak the earth, and water it, and make it to spring, and give seed to the sower, and bread to the eater:

A.D. 346 – 1875 7 witnesses

Patristic

before A.D. 750
346
A.D.
c. A.D. 270–346
“For the rain and the snow do not return to heaven but accomplish in the earth the will of him that sends them. So the word that he shall send through his Christ, who is himself the Word and the Message, shall return to him with great power. For when he shall come and bring it, he shall come down like rain and snow, and through him all that is sown shall spring up and bear righteous fruit, and the word shall return to his sender; but not in vain shall his going have been, but thus shall he say in the presence of his sender, "Behold, I and the children that the Lord has given me." And this is the voice through which the dead shall live. And this is the voice of God that shall sound from on high and raise up all the dead.”
Source

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
“For, just as the rain and the snow fall and do not return empty, but do good for you.”
1167
A.D.
Ibn Ezra Jewish
1089–1167
“For as the rain cometh down, etc. The rain watereth the earth, in coming down from heaven; for that purpose God sends it down, in order that seed may be given to the sower and bread to the eater.”
1256
A.D.
Thomas Aquinas Catholic
1225–1274
“This is the inheritance. Here he applies the third remedy, promising an abundance of things against the former want. And it is divided into two parts: in the first he sets down the promise; in the second he shows the firmness of the promise, and how it comes down. Concerning the first he does three things. First he shows the condition of those to whom it is promised: this is the inheritance; that is, these things that follow are owed to the servants of the Lord, who are his sons, as by hereditary right, and by justice, as a just reward. Ps. 15: my inheritance. Second he sets forth the promise, promising a future abundance in necessary things: all you who thirst, that is, you from among the Jews, who before were thirsting on account of want, buy, without price, eat, bread, and other necessary things. John 7: if anyone thirsts, let him come to me and drink (...) and from his belly there shall flow living waters. And in delights: come, buy, as if to say, as though you were buying, receive; or without silver, that is, for less than the just price. Song 5: I have drunk my wine with my milk. And recalling the former want: why do you weigh out? As if to say: why until now did you give silver, and were not able to buy bread with it? Haggai 1: you have sown much, and brought in little. But these things are expounded mystically of the water of divine wisdom, which is given freely to those who thirst, according to the Gloss. Third he enjoins the preparation for obtaining the said promise: hear, you who hear; and first he rouses attention; second he sets down the exhortation, seek the Lord. Now he rouses attention by a threefold promise. First, promising to those who attend a copious enjoyment of good things: eat, that is, I will refresh you with diverse good things, if you hear me, in fatness, as to abundance. Above, ch.1: if you be willing, and will hear me, you shall eat the good things of the land. Jer. 31: the soul of the priests. Second, promising escape from death: incline. Ps. 118: my soul shall live; again Ps. 118: I will never forget your justifications, for by them you have given me life. Third, promising power. And first he sets down a comparison: and I will strike: that is, just as I made true promises to David, that his seed should remain forever, so I will also do with you. Second he explains it, showing what David did: behold, a witness, Ps. 17: a people whom I have not known has served me; at the hearing of the ear they have obeyed me. And what he will do for them: behold, you shall call nations, to fulfill your command, not by your own strength, but on account of the Lord. Above, ch.49: they shall worship, on account of the Lord your God, who has chosen you. Seek the Lord. Here he enjoins on them the preparation for obtaining the said promise: and first he gives the divine counsel of seeking: seek the Lord while he may be found, before adversity or death comes. Ps. 104: seek the Lord, etc. Prov. 1: they shall rise in the morning, etc. Second he teaches the manner of seeking: let the wicked man forsake, he who sins against God; the unjust man, he who sins against his neighbor. Above, ch.1: take away the evil of your thoughts from before my eyes. Third he sets down the fruit of returning, namely mercy: and let him return, for he is great, that is, of manifold mercy, to forgive. Joel 2: turn to the Lord your God. Fourth he excludes the impediment to mercy: for not the thoughts, as if to say: you are wicked, I am merciful; you think of vengeance, I of mercy. Ezek. 18: are not my ways right, O house of Israel, and are not rather your ways wicked? And as. Here he shows the firmness of the promise: and first he shows the efficacy of the divine word: to me void, that is, without fruit. Wisdom 1: an obscure word. Hosea 6: he shall come like the early and the latter rain. Second he sets down its content as to the joyful release from Babylon, for in joy. Ps. 104: he brought forth his people in exultation, and his chosen ones in gladness. As to the congratulation of others: mountains and hills, the powerful and the common people, praising the Lord in you. Or it is a hyperbole. Your land, congratulating your return. As to the multiplied restitution of goods: instead of the brier, that is, the former things were few in respect of the things to come. Haggai 2: the glory of this latter house shall be greater than that of the former. Above, ch.41: I will give in the wilderness. The saliunca, so called from leaping (saliendo), which is called the hare's thistle. Third he sets down the consequent glory of God: and the Lord shall be named, everywhere and always glorious for your liberation, for an everlasting sign, to which they shall flee as to a sign of salvation. Above, ch.49: behold I will lift up my sign to the nations. Note on that word, all you who thirst come to the waters, that divine teaching is first called water; and this, first, because it heals the sick. Ecclus. 15: he gave him to drink the water of wholesome wisdom. Second, because it cleanses the defiled. Ezek. 36: I will pour upon you clean water, and you shall be cleansed from all your filthiness. Third, because it satisfies those who thirst. John 4: whoever shall drink of the water that I shall give him shall not thirst forever. Second it is called wine; and this because, first, it pricks by reproving. Above, ch.1: your wine is mixed with water. Second, because it kindles by exhorting. Ps. 104: the word of the Lord inflamed him. Third, because it inebriates by consoling. Below, at the end: be inebriated with the breasts of your consolation. Third it is called milk; and this, first, on account of beauty. Gen. 49: Naphtali, a hart let loose, giving words of beauty. Second, on account of sweetness. Song 2: let your voice sound in my ears, for your voice is sweet. Third, on account of the ease of taking it. 1 Pet. 2: as newborn babes, desire milk.”
Source

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“For as the rain cometh down, and the snow from heaven, and returneth not thither,.... Rain and snow come down from the clouds in the heavens, and do not return again until they have done what they are sent to do, or have produced the following effects; otherwise they may be exhaled into vapours, as they often are, and drawn up again by the sun: but watereth the earth, and maketh it bring forth and bud; or, "inebriateth the earth" (n); soaks into it, and reaches the seed that is sown in it, and causes that to spring up, and rise into stalk and ear: that it may give seed to the sower and bread to the eater; produce a sufficiency for food both for man and beast, and enough for seed to sow the ground with the following year. (n) , Sept.; "sed inebriats" Pagninus, Junius & Tremellius; "quin imo inebriavit terram", Montanus.”
Source
1871
A.D.
1871
“The hearts of men, once barren of spirituality, shall be made, by the outpouring of the Spirit under Messiah, to bear fruits of righteousness (Isa 5:6; Deu 32:2; Sa2 23:4; Psa 72:6). snow--which covers plants from frost in winter; and, when melted in spring, waters the earth. returneth not--void; as in Isa 55:11; it returns not in the same shape, or without "accomplishing" the desired end. bud--germinate.”
Source
1875
A.D.
Keil & Delitzsch Lutheran
1861–1875
“This is set forth under a figure drawn from the rain and the snow. "For as the rain cometh down, and the snow from heaven, and returneth not thither, till it has moistened the earth, and fertilized it, and made it green, and offered seed to the sower and bread to the eater; so will my word be which goeth forth out of my mouth: it will not return to me fruitless, till it has accomplished that which I willed, and prosperously carried out that for which I sent it." The rain and snow come down from the sky, and return not thither till they have .... The perfects after אם כּי are all to be understood as such (Ewald, 356, a). Rain and snow return as vapour to the sky, but not without having first of all accomplished the purpose of their descent. And so with the word of Jehovah, which goeth forth out of His mouth (יצא, not יצא, Isa 45:23, because it is thought of as still going on in the preaching of the prophet): it will not return without having effected its object, i.e., without having accomplished what was Jehovah's counsel, or "good pleasure" - without having attained the end for which it was sent by Jehovah (constr. as in Sa2 11:22; Kg1 14:6). The word is represented in other places as the messenger of God (Isa 9:8; Psa 107:20; Psa 147:15.). The personification presupposes that it is not a mere sound or letter. As it goeth forth out of the mouth of God it acquires shape, and in this shape is hidden a divine life, because of its divine origin; and so it runs, with life from God, endowed with divine power, supplied with divine commissions, like a swift messenger through nature and the world of man, there to melt the ice, as it were, and here to heal and to save; and does not return from its course till it has given effect to the will of the sender. This return of the word to God also presupposes its divine nature. The will of God, which becomes concrete and audible in the word, is the utterance of His nature, and is resolved into that nature again as soon as it is fulfilled. The figures chosen are rich in analogies. As snow and rain are the mediating causes of growth, and therefore the enjoyment of what is reaped; so is the soil of the human heart softened, refreshed, and rendered productive or prolific by the word out of the mouth of Jehovah; and this word furnishes the prophet, who resembles the sower, with the seed which he scatters, and brings with it bread which feeds the souls: for every word that proceedeth out of the mouth of God is bread (Deu 8:3).”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.