Isa 57:4

“Since, therefore, history is clear that those who killed Christ were the children of those who did these things, the question occurs as to how they are called "children of perdition," in opposition to those who wish to be of a different nature. The former are evil and lost, unable to be saved, whereas the latter are good, unable to perish. For if, as they think, the children of perdition are worse by nature, how is it possible that one of them could be found who was previously lost? In the parable of the prodigal, moreover, both the one sheep lost out of one hundred and the one silver coin lost out of ten were found again, as was the son, about whom the father said to his elder brother: "This your brother was lost and is found again; he was dead, and now he lives!" For no one perishes unless previously healthy, and no one dies unless previously alive. Therefore, those who are now called children of perdition, or children of iniquity and crime, have failed the Lord by their own fault and thus began to be children of perdition when they were still children of the Lord, as the prophet says to these very people: "You failed the Lord and provoked the holy One of Israel to wrath." We can receive this, according to the tropological sense, as applying to heretics who are children of perdition and the seed of the worst, or liars. For they were liars from the beginning, just like the devil, who is the father of their lie and the father of every lie. … Nor is there any doubt but that such children of perdition and wicked seed will themselves have many children whom they will deceive and murder in deep valleys and in the abyss of impiety, under overhanging rocks that continuously threaten destruction, rocks that are called "many" on account of the diversity of their lies and the variety of their false doctrines. We, by contrast, have one Rock that the people of God continuously follow and from which the people of Israel formerly drank, when they enjoyed familiarity with the Lord.”

“(Verse 4, 5.) Are you not wicked children, a deceitful seed, who console yourselves in gods beneath every leafy tree, sacrificing little ones in the torrents under threatening ((Vulg. lofty)) rocks? LXX: Are you not sons of perdition: an unjust seed, who call upon idols beneath leafy trees, sacrificing your sons in the valleys amidst the rocks? You, he says, have done these things that the preceding discourse narrated. Who are you, wicked sons of perdition, like Judas the betrayer, who is called the son of perdition (Jn. 17): and offspring of wickedness or deceit and falsehood, who delight in gods under every leafy tree, and sacrifice your children in the rivers (Acts 8). This is also recounted in the history of the Kings and Chronicles, that they sacrificed their sons to the gods, and consecrated them in fire (2 Kings 16 and 17). Indeed, it is without a doubt that both Achab, the king of Israel, and Manasseh, the king of Judah, committed, who went from the murder of their own children to the blood of the Prophets, as also mentioned in Hosea: 'Sacrifice,' he says, 'men, for the calves have failed' (Hosea 13:2).' Or, as it is written in Hebrew: 'Sacrificing men, you worship calves.' And in the Psalms it is written more fully: 'They were mingled with the nations, and they learned their works, and they served their idols, and it became a stumbling block to them.' And they sacrificed their sons and daughters to demons, and shed innocent blood, the blood of their sons and daughters, and sacrificed to the idols of Canaan. And the land was contaminated with blood, and was defiled in its works (Psalm 105, 35 et seqq.). Therefore, since it is evident from history that the sons are the murderers of Christ, the question arises as to how the sons are called sons of perdition, against those who wish to be different natures: one that is lost and evil, and cannot be saved; and another that is good, and cannot perish. For if, as they believe, the sons of perdition are of the most wicked nature: how is it that what was lost has been found? In the parables of the repentant, the lost sheep out of a hundred sheep and the lost coin out of ten are found, and the lost son is found, of whom the father had said to the older son: Your brother was lost, and is found: he was dead, and he has come to life again (Luke 15:32). For nothing perishes unless it was first safe, and nothing dies unless it had lived before. Therefore, those who are now called sons of perdition, or of wickedness and crime, have abandoned the Lord through their own fault, and have begun to be sons of perdition from among the sons of the Lord, as the same Prophet says to them: You have forsaken the Lord, and have provoked the Holy One of Israel to anger (Isaiah 1:4). We can understand these words according to the allegorical sense, and apply them to heretics, who are sons of perdition and of the most wicked seed, or of falsehood. For from the beginning they are liars, like the devil, who is their father, who is the father of all lies. They call those whom they have deceived to idols, or to the images of their doctrines, under leafy and wooded trees, promising pleasures and delights to them, or hiding their impurities. Therefore, after Adam sinned, he hid himself in paradise under a tree, so that he would not be revealed to the sight of God (Genesis 3). There is no doubt that the children of such destruction, and the wicked seed, have many offspring wherever they deceive and kill in deep valleys, and under the looming rocks of impiety, which always threaten ruin, which, due to the diversity of lies and the variety of perverse teachings, are called many rocks. But we have one rock, which always follows the people of God, from which the people of Israel once drank, when they enjoyed the intimacy of the Lord.”

“On whom will you [rely to] enjoy yourselves Since you have turned away from following Me, on whom will you rely to enjoy yourselves with good. Had you merited, you would then enjoy yourselves with the Lord, but now, on whom will you rely to enjoy yourselves? against whom do you open your mouth wide when you scorned and mocked His prophets.”

“First, he accuses them of blasphemy, setting out the custom of sin, inasmuch as they imitate their fathers in this: you sons of the sorceress, who tended to auguries against my commandment, the seed of the adulterer, inasmuch as they abandoned me and adhered to idols: judge your mother, judge her (Hos 2:2). He also sets out the species of sin: upon whom have you jested? As if to say: upon God, blaspheming him, above: whom have you reproached? (Isa 37:23). Second, he accuses them of idolatry. And first, he sets out the custom: are not you wicked children, above: woe to the sinful nation, a wicked people, ungracious children (Isa 1:4); second, he sets out the species of sin: who seek your comfort in idols.”