John Gill, on Jer 51:21

“And with thee I will break in pieces the horse, and his rider, and with thee I will break in pieces the chariot, and him that getteth up into it:”

“And I will also break in pieces with thee the shepherd and his flock,.... Or, have broken; which Abarbinel thinks respects the Arabians particularly, who were shepherds, and dwelt in tents; but it rather signifies shepherds and their flocks in general; who were killed or scattered wherever his armies came, which spared none, even the most innocent and useful, and though unarmed: and with thee will I break in pieces the husbandman and his yoke of oxen; with which he ploughed his ground: signifying by this, as well as the former, that those were not spared, by which kingdoms were supported and maintained, as shepherds and husbandmen: and with thee will I break in pieces captains and rulers; by whom kingdoms and states are governed and protected.”

Imported from an open dataset — not yet checked against the printed edition.