Origen

(tom. xix. 3.) The Word, while still present, yet threatens to depart. So long as we preserve the seeds of truth implanted in our minds, the Word of God does not depart from us. But if we fall into wickedness, then He says to us, I go away; and when we seek Him, we shall not find Him, but shall die in our sin, die caught in our sin. But we should not pass over without notice the expression itself: Ye shall die in your sins. If ye shall die be understood in the ordinary sense, it is manifest that sinners die in their sins, the righteous in their righteousness. But if we understand it of death in the sense of sin; then the meaning is, that not their bodies, but their souls were sick unto death. The Physician seeing them thus grievously sick, says, Ye shall die in your sins. And this is evidently the meaning of the words, Whither I go ye cannot come. For when a man dies in his sin, he cannot go where Jesus goes: no dead man can follow Jesus: The dead praise not Thee, O Lord. (Ps. 113)