John Gill

Man that is in honour,.... A wicked man, as the Targum; See Gill on Psa 49:12; and understandeth not; from whence his riches and honour, come, and what use he should make of them, and for what end he has them; or that understandeth not spiritual things, which relate to the salvation of his soul; who does not know God in Christ, nor the way of salvation by Christ; nor has any experience of the work of the Spirit of God upon his soul; nor has any spiritual understanding of the doctrines of the Gospel; nor knows himself, his state and condition, and what true happiness is: is like the beasts that perish; See Gill on Psa 49:12. Next: Psalms Chapter 50