The interpretation timeline
1 Thessalonians 4:8 Douay-Rheims

Therefore, he that despiseth these things, despiseth not man, but God, who also hath given his holy Spirit in us.

A.D. 220 – 1871 6 witnesses 7 excerpts

Patristic

before A.D. 750
220
A.D.
Tertullian Patristic
c. A.D. 150–220
“But if repentance is a thing human, its baptism must necessarily be of the same nature: else, if it had been celestial, it would have given both the Holy Spirit and remission of sins. But none either pardons sins or freely grants the Spirit save God only. Even the Lord Himself said that the Spirit would not descend on any other condition, but that He should first ascend to the Father.”
Source
407
A.D.
John Chrysostom Patristic
A.D. 347–407
“"And don't grieve," he adds, "the Holy Spirit of God." This is a terrible and startling matter, as he also says in the epistle to the Thessalonians. For there he uses an expression of this sort. "He that rejects, rejects not man, but God." It is the same here. If you utter a reproachful word, if you strike your brother, you are not striking him; rather you are "grieving the Holy Spirit."”
Source
“"Therefore he that rejecteth, rejecteth not man, but God, who giveth His Holy Spirit unto you." So that even if thou shouldest defile the Empress, he says, or even thine own handmaid, that hath a husband, the crime is the same. Why? Because He avenges not the persons that are injured, but Himself. For thou art equally defiled, thou hast equally insulted God; for both the one and the other is adultery, as both the one and the other is marriage. And though thou shouldest not commit adultery, but fornication, though the harlot has no husband, yet nevertheless God avenges, for He avenges Himself. For thou dost this act, not despising the man, so much as God. And it is manifest from this, that thou doest it concealing it from man, but thou pretendest that God doth not see thee. For tell me, if one who was thought worthy of the purple, and of infinite honor from the king (Emperor), and was commanded to live suitably to the honor, should go and defile himself with any woman; whom has he insulted? her, or the king who gave him all? She indeed is insulted too, but not equally.”
Source

Scholastic

c. 1100 – 1500
1272
A.D.
Thomas Aquinas Catholic
1225–1274
“Above, the Apostle commended the faithful for their constancy in tribulations and other goods; here he admonishes them, for the future, to act well. And first he sets forth a general admonition; second he specifies, at "that you abstain." Concerning the first he does two things: first he sets forth his intention, second he assigns the reason for the admonition, at "that you may abound," etc. He says therefore: I have heard of your past goods, but for the future we ask, etc. He induces them, first, on his own part. And so he says "we ask." Ps. 121:6: "Ask the things that are for peace," etc. Likewise on Christ's part, and so he says "we beseech," etc. He beseeches, however, because they were perfect. 1 Tim. 5:1: "Do not rebuke an elder, but beseech him as a father." But what does he ask? "That just as," etc. The Apostle had taught them how they ought to walk in the common way of justice, which is through the commandments. Hence he says: "you have received," etc. Ps. 118:32: "the way of your commandments," etc. Likewise how they might please God in the way of counsels. Wis. 4:10: "Being pleasing to God, he was made beloved." Or how you should walk, namely through right action. Jn. 12:35: "Walk while you have the light." How you should please, namely through right intention. "So also you may walk" — that is, that you keep to the first doctrine, not withdrawing from it. Gal. 1:8: "But though we, or an angel from heaven, should preach to you besides that which we have preached to you, let him be anathema." The reason for the admonition is taken, first, from the fruit of keeping the admonition; second, from the admonition itself, at "for you know what," etc. He says therefore: although you are good, yet through the exercise of the commandments and counsels you will abound and progress. 2 Cor. 9:8: "God is able to make all grace abound in you." For charity is so great that there always remains that in which one may progress. Likewise, the things which you received from the admonition are honorable and useful. Ps. 18:8: "The law of the Lord is unspotted," etc. Prov. 6:23: "The commandment is a lamp, and the law a light, and the way of life." Therefore he says "what precepts" — that is, of what sort. And this received through the Lord Jesus, from him. 1 Cor. 11:23: "For I have received of the Lord that which also I delivered unto you," etc. Heb. 2:3: "which, since it had received its beginning to be declared through the Lord, from those who heard," etc. And these are these things. "This is the will of God, your sanctification" — as if he were to say: all the precepts of God are for this, that you may be holy. For holiness denotes cleanness and firmness. And all the precepts of God lead to these: that one be clean from evil, and firm in good. Rom. 12:2: "that you may prove what is the will of God" — namely, as explained through the precepts. Then, when he says "that you abstain," he admonishes in particular. And first he corrects them concerning certain disorders among them; second he urges them to the observance of good things, in chapter 5, at "concerning the times." Now there were three disorders among them: namely, of carnal vices as regards some, likewise of curiosity, likewise of sorrow over the dead; and therefore he treats of these. The second, at "but concerning charity." The third, at "we would not have you." Concerning the first he does two things: first he admonishes them to abstain from an immoderate appetite for carnal things; second he gives the reason, at "because the avenger." Again, the first is divided into two, because first he forbids lust; second, avarice. And he always joins these together, because each is concerned with a bodily object, although this is completed in spiritual delight. Likewise, first he teaches to beware of lust as regards one not one's own; second as regards one's own wife, at "that he may know." He says therefore "that you abstain from fornication." For it is the will of God to abstain from fornication; therefore it is a mortal sin, because it is against the precept and will of God. Tob. 4:13: "Keep yourself from all fornication." But also with respect to one's wife you should abstain honorably, so that each one may know how to possess his vessel — that is, his wife — "in sanctification," ceasing for a time, "and in honor, not in passion" — namely, so that passion should go before — "even as the Gentiles" — because this is the way of the Gentiles, to seek present delights, but not those of the future life. "In sanctification and honor," because here is the due use of marriage, which is for the good of offspring, or for rendering the debt, and thus it can be without sin; but sometimes it is a venial sin, if concupiscence is not carried beyond the bounds of marriage — namely when, although he has concupiscence, he would nevertheless not use it unless she were his wife. But when it is outside the bounds of marriage, mortal sin follows, and this is when, if she were not his wife, he would still use her, and more willingly with another. Heb. last [chapter], 4: "Let marriage be honorable, and the bed undefiled." "But fornicators and adulterers God will judge." 1 Pet. 3:7: "Husbands likewise dwelling with them according to knowledge, giving honor to the woman as to the weaker vessel, as to co-heirs of grace and life, that your prayers be not hindered." Then, when he says "and let no man," he forbids avarice. Hence he says "and let no man overreach" — that is, use violence by taking away another's goods through power. Jas. 2:6: "Do not the rich oppress you by might?" Nor circumvent by deceit. Jer. 5:27: "As a snare full of birds, so their houses are full of deceit." Then, when he says "because the avenger," etc., the reason for the admonition is given, which he first assigns from divine vengeance; second he shows this vengeance to be just, at "for he has not called." He says therefore: let us abstain from these things, because "the Lord is the avenger." Gal. 5:21: "I foretell you, as I have foretold you, that they who do such things shall not obtain the kingdom of God." For certainly he avenges justly, of which there is one reason from God calling, a second from the contrariety to the gift. If the Lord calls you to one thing, and you do the contrary, you are worthy of punishment. And therefore he says "for he has not called," etc. Eph. 1:4: "He chose us in him before the foundation of the world, that we should be holy and unspotted in his sight in charity." Rom. 8:30: "whom he called, them he also justified," etc. Therefore he says "therefore," etc.; as if to say: this is one special reason which I have stated. There is another reason, because these vices are contrary to the Spirit, who has been given to us. Hence, whoever does these things does injury to the Holy Spirit. Therefore he says "who also," etc. Heb. 10:28: "A man making void the law of Moses dies without any mercy, on the word of two or three witnesses; how much more, do you think, does he deserve worse punishments, who has trodden underfoot the Son of God, and has held the blood of the testament unclean in which he was sanctified, and has done despite to the Spirit of grace?" Then, when he says "but concerning charity," etc., he draws them back from idleness. Now it must be known that, as Jerome says in his letter to the Galatians, the Thessalonians were generous, and it was their custom for the rich to give much; and therefore the poor idly clung to their benefaction, not caring for labors, but running about through houses. And therefore first he commends the generosity of the givers; second he dissuades the idleness of the receivers, at "and that you give attention." He says therefore, first, that they do not need to be admonished to charity; second he admonishes that they progress in it, at "but we ask." He says therefore "but concerning the charity of brotherhood" — that is, that you love the brethren — "it is not necessary to write to you." Rom. 12:10: "Loving one another with the charity of brotherhood." Heb. last [chapter]: "Let the charity of brotherhood remain in you." And the reason is because "you yourselves have learned from God" — namely, the precept in the law. Lev. 19:18: "You shall love your friend as yourself." Likewise in the Gospel. Jn. 13:34: "A new commandment I give you, that you love one another," etc. Or, you have learned by interior instruction. Jn. 6:45: "Everyone who has heard from the Father, and has learned, comes to me," etc. And this he learns through the Holy Spirit. Then, when he says "but we ask," he exhorts them to progress in charity, saying: and because you have charity toward all, therefore we ask that you progress. And although others abuse it, you nevertheless should persist. Prov. 15:5: "In abundant justice virtue is greatest." Then, when he says "and that you give attention," he reproves the idle: first their restlessness; second he shows how they should repress it; third, why. He says therefore: "that you give attention, that you be quiet." Prov. 7:10: "talkative and wandering, impatient of quiet, nor able to remain in the house with her feet," etc. 2 Thess. 3:7: "We were not restless among you, neither did we eat any man's bread for nothing, but in labor and weariness, working night and day," etc. Repressing idleness by exercising business. Hence he says "and that you do your own business." Prov. 24:27: "Diligently work your field, that afterward you may build your house." He says, however, "your own" — but is it not the case that another's business is also to be done? And it seems that it is so. Rom. last [chapter]: "that you assist her in whatever business." I respond. It must be said that all things can be done in a disordered way, if they are done outside the order of reason — namely when someone conducts himself dishonestly — and in an ordered way, namely when the order of reason is kept, and in necessity, and this is commendable. "And that you work with your own hands" — that is, by working with your hands. Ecclus. 33:29: "Idleness has taught much evil," etc. Ezek. 16:49: "This was the iniquity of Sodom your sister: pride, fullness of bread, and abundance, and the idleness of her and of her daughters, and they did not reach out a hand to the needy and the poor," etc. And this is a precept for all those who do not have other means by which they can live lawfully; because it is a precept of nature that a man should sustain his body. 2 Thess. 3:10: "He who is not willing to work, let him not eat either." Of this there is a twofold reason. The first, on account of the example to others. Hence he says "that also honestly," etc. For unbelievers, seeing your manner of life so idle, detest you. 1 Tim. 3:7: "But he must have a good testimony from those who are outside," etc. The second reason, that you should not desire the things that are others'; hence it is said "and that you desire nothing of any man's." Prov. 21:25: "Desires kill the slothful." Eph. 4:28: "He who stole, let him now steal no more," etc. And therefore, if this restlessness is repressed, it results in good example, and in the repression of desire.”

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“He therefore that despiseth,.... The Vulgate Latin adds, "these things"; these exhortations now delivered, the commandments given by the Lord Jesus Christ, and the will of God above declared; he that rejects these things with contempt, takes no notice of them, and acts not according to them, despiseth not man; not men only, the apostles of Christ, and ministers of the Gospel; for, by despising these exhortations, they themselves were despised, though not alone: but God; Father, Son, and Spirit; God the Father, whose will was their sanctification, even to abstain from fornication, and every act of uncleanness, which, if not attended to, was a despising of him; and the Lord Jesus Christ, by whom, and for whose sake they were entreated and exhorted, and in whose name, and by whose authority the apostle gave them these commandments; wherefore to slight them, was to slight Jesus Christ himself; and, by the way, this is a proof of the true and proper deity of Christ. Moreover, such despisers also, in some sense, do despite unto the spirit of grace, by whom the apostles spake, or who spoke in them these things, as follows, who hath also given unto us his Holy Spirit; as he did to the prophets of the Old Testament, and therefore what they said was equally by divine inspiration of God; and hence despising them, was despising the Spirit of God that spake by them. The Syriac and Arabic versions read, "who hath given unto you his Holy Spirit"; and so all Stephens's copies; which furnishes out a fresh reason or argument, dissuading from uncleanness, since God had given them his "Spirit" to convince them of sin, of righteousness, and of judgment, so that they were not ignorant of the things warned against; and he had given them his Spirit as an "holy" Spirit, as a Spirit of sanctification, to begin and carry on that work in them, to which uncleanness was very opposite; and he had given his Spirit unto, or "into" them, to dwell in them, as in his temple, and therefore should be careful not to defile it; and to cause them to walk in his statutes, and to assist them to keep his judgments, and do them, and as an earnest of their inheritance, and a sealer of them up unto the day of redemption; wherefore it became them not to grieve him by an impure life; and they were laid under obligations to live in the Spirit, and to walk after him, and not after the flesh.”
Source
1832
A.D.
Adam Clarke Methodist
1762–1832
“He therefore that despiseth - He who will not receive these teachings, and is led either to undervalue or despise them, despises not us but God, from whom we have received our commission, and by whose Spirit we give these directions. See Clarke's note on Th1 4:15. Hath also given unto us his Holy Spirit - Instead of εις ἡμας, unto Us, εις ὑμας, unto You, is the reading of BDEFG, a great many others, the Syriac, all the Arabic, Armenian, later Syriac in the margin, some of the Itala, Clement, Didymus, and Ambrosiaster; this seems to be the better reading. God has taught us that we may teach you; and he has also given you his Holy Spirit that ye might understand and be enabled to practice these things. It is one thing to receive a revelation from the Spirit of God; it is another thing to receive that Spirit to enable a man to live according to that revelation. In the first sense the apostles alone received this Holy Spirit; in the latter sense all true Christians, as well as the Thessalonians, receive it. I think ὑμας, you, is the true reading, and that it is confirmed by the following verse: For ye yourselves are Taught of God to love one another. Griesbach has inserted it in the margin, but has not admitted it into the text, because it has not what he deemed full support from those MSS. which are of the Alexandrian recension; but he thought its genuineness very probable.”
Source
1871
A.D.
1871
“despiseth, &c.--Greek, "setteth at naught" such engagements imposed on him in his calling, Th1 4:7; in relation to his "brother," Th1 4:6. He who doth so, "sets at naught not man (as for instance his brother), but God" (Psa 51:4) is used of despising or rejecting God's minister, it may mean here, "He who despiseth" or "rejecteth" these our ministerial precepts. who hath also given unto us--So some oldest manuscripts read, but most oldest manuscripts read, "Who (without 'also') giveth (present) unto you" (not "us"). his Spirit--Greek, "His own Spirit, the Holy (One)"; thus emphatically marking "holiness" (Th1 4:7) as the end for which the Holy (One) is being given. "Unto you," in the Greek, implies that the Spirit is being given unto, into (put "into" your hearts), and among you (compare Th1 2:9; Eph 4:30). "Giveth" implies that sanctification is not merely a work once for all accomplished in the past, but a present progressive work. So the Church of England Catechism, "sanctifieth (present) all the elect people of God." "His own" implies that as He gives you that which is essentially identical with Himself, He expects you should become like Himself (Pe1 1:16; Pe2 1:4).”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.