The interpretation timeline
2 Timothy 2:22 Douay-Rheims

But flee thou youthful desires, and pursue justice, faith, charity, and peace, with them that call on the Lord out of a pure heart.

A.D. 407 – 1871 7 witnesses

Patristic

before A.D. 750
407
A.D.
John Chrysostom Patristic
A.D. 347–407
“"Flee also youthful lusts." Not only the lust of fornication, but every inordinate desire is a youthful lust. Let the aged learn that they ought not to do the deeds of the youthful. If one be given to insolence, or a lover of power, of riches, of bodily pleasures, it is a youthful lust, and foolish. These things must proceed from a heart not yet established, from a mind not deeply grounded, but in a wavering state. What then does he advise in order that none may be captivated by these things? "Flee youthful" imaginations, "but Follow righteousness, faith, charity, peace, with them that call on the Lord out of a pure heart." He calls virtue in general, "righteousness": godliness of life, "faith, meekness, charity." What is meant by "those that call upon the Lord out of a pure heart"? It is as if he said, Rejoice not in those who only call upon the Lord; but those who call upon Him sincerely and unfeignedly, who have nothing of deceit about them, who approach Him in peace, who are not contentious. With these associate thyself. But with others be not easy, but only as far as lies in you, be peaceable.”
Source

Scholastic

c. 1100 – 1500
1273
A.D.
Thomas Aquinas Catholic
1225–1274
“Above he showed that profane things are to be avoided by an argument taken from harm; here he shows the same thing by an argument taken from fruit. And first he sets forth the avoidance; second, its fruit, at the words *he shall be a vessel*. For he calls the avoidance a cleansing. He says therefore: there are certain vessels unto dishonor; therefore if anyone shall have cleansed himself from these, because the fellowship of such men defiles. Ecclus. 13:1: "He who touches pitch shall be defiled by it." And therefore they are to be fled. 2 Cor. 9: "Go out from the midst and be separated, says the Lord, and touch not the unclean thing," etc. But the fruit that follows is fourfold. The first is from the ordering toward glory, because *he shall be a vessel unto honor*; because if he is defiled by them, he will be unto dishonor; if he cleanses himself, unto honor. Ps. 138:17: "Friends are made exceedingly honorable," etc. Prov. 25:4: "Take away the rust from silver, and there shall come forth a most pure vessel." The other effects are of grace, of which the first is the sanctification of man; the second is the ordination of man through right intention; the third through the execution of the work. As to the first, therefore, he says *sanctified*. 1 Cor. 6:11: "You are washed, you are sanctified." But as to the second he says *useful to the Lord*. But does he need our service? No. Ps. 15:2: "You have no need of my goods." But he says *useful to the Lord*, that is, its usefulness will redound to the honor of the Lord. Acts 9:15: "that he may carry my name before the Gentiles, and kings, and the children of Israel." As to the third he says *prepared unto every good work*. Ps. 118:60: "I am ready, and am not troubled." And he says *unto every good*, because affirmative precepts do not oblige always. And therefore he ought to be prepared, so that he may act when it is necessary. Then, when he says *youthful*, he shows how profane things are to be avoided. And he sets down two things to be avoided: the first is depraved conduct; the second is bad doctrine, at the words *but foolish*. Concerning the first he does two things, because first he shows what is to be avoided; second, what is to be followed, at the words *follow after*. He says therefore: I say that you ought to avoid these things, so that you may be a cleansed vessel; therefore *youthful*, etc. It should be considered that he says this because this one was young. And these are the desires of external vanities, and of carnal pleasures. It is natural for the young to desire these things. Eccl. 11:10: "youth and pleasure are vain." Of which there is a twofold reason. One, because they have not experienced other things; the second, because delights of this kind are naturally ordered as a medicine against labors. But nature labors in the young, and therefore they are inclined toward them. Then, when he says *but follow after justice, faith, hope, charity, and peace*, he shows what things are to be followed. And they are four, of which the first orders one toward subjects, and this is justice, because the prince is the guardian of justice. Prov. 20:8: "The king who sits on the throne of judgment scatters all evil with his look." The second orders one toward him, and this is faith, without which it is impossible to please God, Heb. 11:6. The third is hope. The fourth orders one toward each neighbor, namely charity and peace, which extends even to enemies. 1 Cor. 13:2: "If I should have faith, so that I might move mountains, but have not charity, I am nothing." From charity follows joy. But peace implies ordered concord. But what he adds, *with those who call upon*, etc., can be expounded in one way by referring it to what was immediately said; as if he were to say: follow after peace with these, etc. And what he says, *out of a pure heart*, is set down, because it is not a specious praise, etc. But Heb. 12:14 says: "Follow peace with all men." Why then is it said here, *with those who call upon the Lord out of a pure heart*? I respond. It must be said that, as much as is in us, we ought to have peace with all, if it can be done; but there cannot be peace between the good and the wicked, because peace implies concord, which cannot be had with the wicked. In another way, *with these*, etc., is read so as to be referred to the whole preceding passage; as if he were to say: follow after justice, peace, and all things, just as also those who call upon, etc., do. Then, when he says *but foolish*, he exhorts to the avoidance of bad doctrine. And first he teaches what is to be avoided; second, what is to be followed, at the words *but gentle*. Concerning the first he does two things; because first he sets forth the teaching; second, he assigns the reason, at the words *knowing that*. Foolish questions are to be avoided, as to their matter, because they are about foolish things, that is, about those things which are contrary to wisdom, that is, about those things which are against divine wisdom. Man ought not to raise these, but to resist them. Jer. 10:14: "Every man has become foolish by his own knowledge." But he says *without discipline*, as to the manner, because they are clamorous. Or *without discipline* on the part of those things about which doubt is raised, as for instance if one should turn into doubt what the whole Church holds. Job 34:35: "But Job has spoken foolishly, and his words do not sound discipline." But questions are to be loved only insofar as they lead to truth: by this, that it is fitting that all should say one thing. But foolish questions do not lead to truth, but to strife, which is to be avoided. Is. 58:4: "Behold, you fast unto strife and contention," etc. And therefore he says *but the servant of the Lord*, that is, him who gives himself to the service of the Lord, *must not wrangle*. 1 Tim. 3:33: "not quarrelsome." Then, when he says *but gentle*, he shows what is to be followed. And first he sets down the teaching; second, the reason, at the words *lest at any time he give*. Again, the first is divided into two, because first he sets forth a certain general thing for all; second, certain things necessary for each, at the words *teachable*. The general thing which he who wishes to dispute ought to have, is that he be gentle. Ps. 24:9: "He will teach the meek his ways." For gentleness is a virtue restraining from anger, which disturbs the judgment of reason, which is necessary in inquiry and in the judgment of truth. Matt. 11:29: "Learn from me, because I am meek and humble of heart." In particular, however, he ought to have, with respect to superiors, teachableness; with respect to persecutors, patience; with respect to false teachers, correction. As to the first he says *teachable*, that is, ready to be corrected by anyone. And this is heavenly wisdom. James 3:17: "But the wisdom that is from above is first indeed chaste; then peaceable, modest, persuadable," etc. As to the second he says *patient*. Ps. 91:15: "They shall be well patient, that they may declare." Prov. 19:11: "The learning of a man is known through patience." As to the third he says *correcting with modesty*, because correction ought to be modest. Gal. 6:1: "You who are spiritual, instruct such a one in the spirit of gentleness," etc. Then, when he says *lest at any time*, he assigns the reason for the avoidance, and answers a certain tacit question. For someone could say: these resist the truth, and therefore the necessity of correcting is imminent. I respond that God the Father can lead them back to repentance, and toward this the just man ought to strive. And first he sets forth beforehand the repentance, which he ought to intend against adversaries; second, the fruit of repentance; third, the necessity of repentance. He says therefore *lest at any time*, that is, that God may at some time give them repentance, because they resist out of pride, to whom it seems difficult that repentance be given. Here the error of Pelagius is excluded, who says that the gifts of grace are from our works, which is shown by this to be false, because even the beginning of good things, namely repentance, is given by God. Lam. 5:21: "Convert us, O Lord, to you, and we shall be converted." Prov. 19: "From your fear we have conceived." But the fruit of repentance is twofold, namely the knowledge of truth, and liberation from the power of the devil. As to the first he says *unto the knowledge of the truth*, because when the truth is resisted out of malice, that very malice of theirs blinds them; therefore when the malice is taken away, they know the truth. John 8:32: "And you shall know the truth." As to the second he says *and may recover themselves from the snares of the devil*, that is, from the occasions of errors on the part of the intellect, such as false imaginings, and on the part of the affections, such as are envy, pride, and things of this kind. But the necessity of repentance is great, for unless they have it, the devil dominates over them. Hence he says *by whom they are held captive*, because "he who commits sin is the slave of sin," John 8:34. And he says *unto his will*, namely, to be followed. Or: so that he may do his own will concerning man. But on the contrary, he does not immediately cast down as he would wish. It must be said that he obtains only as much as is permitted to him; but it is difficult that what he holds be taken away from him. Is. 49:24: "Shall the prey be taken from the strong? or can that which is taken by the mighty be safe?"”

Post-Reformation

c. 1650 – 1900
1714
A.D.
Matthew Henry Reformed
1662–1714
“I. Paul here exhorts Timothy to beware of youthful lusts, Ti2 2:22. Though he was a holy good man, very much mortified to the world, yet Paul thought it necessary to caution him against youthful lusts: "Flee them, take all possible care and pains to keep thyself pure from them." The lusts of the flesh are youthful lusts, which young people must carefully watch against, and the best must not be secure. He prescribes an excellent remedy against youthful lusts: Follow righteousness, faith, charity peace, etc. Observe, 1. Youthful lusts are very dangerous, for which reason even hopeful young people should be warned of them, for they war against the soul, Pe1 2:11. 2. The exciting of our graces will be the extinguishing of our corruptions; the more we follow that which is good the faster and the further we shall flee from that which is evil. Righteousness, and faith, and love, will be excellent antidotes against youthful lusts. Holy love will cure impure lust. - Follow peace with those that call on the Lord. The keeping up of the communion of saints will take us off from all fellowship with unfruitful works of darkness. See the character of Christians: they are such as call on the Lord Jesus Christ, out of a pure heart. Observe, Christ is to be prayed to. It is the character of all Christians that they call upon him; but our prayers to God and Christ are not acceptable nor successful except they come out of a pure heart. II. He cautions him against contention, and, to prevent this (Ti2 2:23), cautions him against foolish and unlearned questions, that tend to no benefit, strifes of words. Those who advanced them, and doted upon them, thought themselves wise and learned; but Paul calls them foolish and unlearned. The mischief of these is that they gender strifes, that they breed debates and quarrels among Christians and ministers. It is very remarkable how often, and with what seriousness, the apostle cautions Timothy against disputes in religion, which surely was not without some such design as this, to show that religion consists more in believing and practising what God requires than in subtle disputes. - The servant of the Lord must not strive, Ti2 2:24. Nothing worse becomes the servant of the Lord Jesus, who himself did not strive nor cry (Mat 12:19), but was a pattern of meekness, and mildness, and gentleness to all, than strife and contention. The servant of the Lord must be gentle to all men, and thereby show that he is himself subject to the commanding power of that holy religion which he is employed in preaching and propagating. - Apt to teach. Those are unapt to teach who are apt to strive, and are fierce and froward. Ministers must be patient, bearing with evil, and in meekness instructing (Ti2 2:25) not only those who subject themselves, but those who oppose themselves. Observe, 1. Those who oppose themselves to the truth are to be instructed; for instruction is the scripture-method of dealing with the erroneous, which is more likely to convince them of their errors than fire and faggot: he does not bid us kill their bodies, under pretence of saving their souls. 2. Such as oppose themselves are to be instructed in meekness, for our Lord is meek and lowly (Mat 11:29), and this agrees well with the character of the servant of the Lord (Ti2 2:24): He must not strive, but be gentle to all men, apt to teach, patient. This is the way to convey truth in its light and power, and to overcome evil with good, Rom 12:21. 3. That which ministers must have in their eyes, in instructing those who oppose themselves, must be their recovery: If God, peradventure, will give them repentance to the acknowledging of the truth. Observe, (1.) Repentance is God's gift. (2.) It is a gift with a peradventure in the case of those who oppose themselves; and therefore, though we are not to despair of the grace of God, yet we must take heed of presuming upon it. To the acknowledging of the truth. (3.) The same God who gives us the discovery of the truth does by his grace bring us to the acknowledging of it, otherwise our hearts would continue in rebellion against it, for we are to confess with our mouths as well as to believe with our hearts, Rom 10:9, Rom 10:10. And thus sinners recover themselves out of the snare of the devil; see here, [1.] The misery of sinners: they are in the snare of the devil, and are led captive by him at his will, Ti2 2:26. They are slaves to the worst of task-masters; he is the spirit that now worketh in the children of disobedience, Eph 2:2. They are taken in a snare, and in the worst snare, because it is the devil's; they are as fishes that are taken in n evil net, and as the birds that are caught in the snare. Further, They are under Ham's curse (a servant of servants shall he be, Gen 9:25), they are slaves to him who is but a slave and vassal. [2.] The happiness of those who repent: they recover themselves out of this snare, as a bird out of the snare of the fowler; the snare is broken and they have escaped; and the greater the danger the greater the deliverance. When sinners repent, those who before were led captive by the devil at his will come to be led into the glorious liberty of the children of God, and have their wills melted into the will of the Lord Jesus. The good Lord recover us all out of the snare.”
Source
1771
A.D.
John Gill Reformed
1697–1771
“Flee also youthful lusts,.... Meaning not lusts of uncleanness, lasciviousness, and filthiness; nor any of those follies and vanities which the youthful age usually lusts and desires after, to which Timothy was not inclined; but such lusts as are apt to prevail with young ministers of the Gospel, such as vain glory, popular applause, seeking to have the pre-eminence, contentions with, and contempt of others, and the like. But follow righteousness; the righteousness of Christ; or doing that which is just between man and man, and as one man would choose another should do to him; or rather integrity and faithfulness, in the ministry of the word, without seeking honour from men: faith; both as a doctrine and grace; or veracity and truth in preaching the Gospel, striving for that, and not through ambition, and for the pre-eminence: charity; or love, to God and Christ, and to his people; without which all gifts and works are of no avail; and which will engage a man to bear much, and to hope and believe all things: peace with them that call on the Lord out of a pure heart; peace is to be pursued and followed after with all men, as much as possible, but especially with the saints, the true worshippers of God; who draw nigh to him with true hearts, and call upon him in the sincerity of their souls: great care should be taken that peace be maintained with them; for they have great interest at the throne of grace; and God is nigh unto them, and hears their prayers. The Alexandrian copy reads, "with all that love the Lord".”
Source
1832
A.D.
Adam Clarke Methodist
1762–1832
“Flee also youthful lusts - Not only all irregular and sensual desires, but pride, ambition, and, above all, the lust of power, to which most men will sacrifice all other propensities, their ease, pleasure, health, etc. This is the most bewitching passion in the human heart. Both in Church and state it is ruinous; but particularly so in the former. Timothy was now between thirty and forty years of age, the very age in which ambition and the love of power most generally prevail. Carnal pleasures are the sins of youth; ambition and the love of power the sins of middle age; covetousness and carking cares the crimes of old age. Follow righteousness - Flee from sin, pursue goodness. Righteousness - whatever is just, holy, and innocent. Faith - fidelity both to God and man, improving that grace by which thy soul may be saved, and faithfully discharging the duties of thy office, that thou mayest save the souls of others. Charity - love to God and man. Peace among all the members of the Church, and as far as possible with all men; but especially among those who invoke the Lord out of a pure desire to glorify his name.”
Source
1849
A.D.
1774–1849
“Youthful desires of any kind, not only of luxury and intemperance. (Witham)”
1871
A.D.
1871
“Flee--There are many lusts from which our greatest safety is in flight (Gen 39:12). Avoid occasions of sin. From the abstemious character of Timothy (Ti1 5:23) it is likely that not animal indulgences, but the impetuosity, rash self-confidence, hastiness, strife, and vainglory of young men (Jo1 2:14-16), are what he is here warned against: though the Spirit probably intended the warning to include both in its application to the Church in general. also--Greek, "But"; in contrast to "every good work," Ti2 2:21. youthful--Timothy was a youth (Ti1 4:12). righteousness--the opposite of "iniquity," that is, unrighteousness (Ti2 2:19; compare Ti1 6:11). peace, with, &c.--rather, put no comma, "peace with them that call on the Lord out of a pure heart" (Ti1 1:5; Eph 6:5; Col 3:22). We are to love all men, but it is not possible to be at peace with all men, for this needs community of purpose and opinion; they alone who call on the Lord sincerely (as contrasted with the false teachers who had only the form of godliness, Ti2 3:5, Ti2 3:8; Tit 1:15-16) have this community [THEODORET]. (Rom 12:18).”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.