The interpretation timeline
Genesis 12:2 Douay-Rheims

And I will make of thee a great nation, and I will bless thee, and magnify thy name, and thou shalt be blessed.

A.D. 99 – 1832 7 witnesses

Patristic

before A.D. 750
99
A.D.
Clement of Rome Patristic
d. A.D. 99
“Abraham, styled "the friend," [Isaiah 41:8] was found faithful, inasmuch as he rendered obedience to the words of God. He, in the exercise of obedience, went out from his own country, and from his kindred, and from his father's house, in order that, by forsaking a small territory, and a weak family, and an insignificant house, he might inherit the promises of God. For God said to him, "Get you out from your country, and from your kindred, and from your father's house, into the land which I shall show you. And I will make you a great nation, and will bless you, and make your name great, and you shall be blessed. And I will bless them that bless you, and curse them that curse you; and in you shall all the families of the earth be blessed." [Genesis 12:1-3] And again, on his departing from Lot, God said to him, "Lift up your eyes, and look from the place where you now are, northward, and southward, and eastward, and westward; for all the land which you see, to you will I give it, and to your seed forever. And I will make your seed as the dust of the earth, [so that] if a man can number the dust of the earth, then shall your seed also be numbered." [Genesis 13:14-16] And again [the Scripture] says, "God brought forth Abram, and spoke unto him, Look up now to heaven, and count the stars if you are able to number them; so shall your seed be. And Abram believed God, and it was counted to him for righteousness." [Genesis 15:5-6] On account of his faith and hospitality, a son was given him in his old age; and in the exercise of obedience, he offered him as a sacrifice to God on one of the mountains which He showed him. [Genesis 22:9]”
Source
407
A.D.
John Chrysostom Patristic
A.D. 347–407
“The scope of the promise is extraordinary: "I will make you a great nation; I will bless you and magnify your name." Not only will I place you at the head of a great nation and cause your name to be great, but as well, "I will bless you, and you will be blessed." I will favor you with so much blessing, he says, that it will last for all time. "You will be blessed" to such an extent that everyone will be anxious to thrust themselves into your company in preference to the highest honor. See how God right from the beginning foretold to him the honor he would later confer upon him. "I will make you a great nation," he said; "I will magnify your name; I will bless you, and you will be blessed." Hence the Jews too found in the patriarch grounds for self-importance and endeavored to establish their kinship with him in the words "We are the children of Abraham." For you to learn, however, that on the basis of their evil ways they are in fact unworthy of such kinship, Christ says to them, "If you were children of Abraham, you would do the works of Abraham." John too, the son of Zechariah, when those anxious to be baptized flocked to the Jordan, said to them, "Brood of vipers, who warned you to flee from the wrath to come? Bear fruit that benefits repentance, and don't presume to say, 'We have Abraham for our father.' I tell you, after all, that God can raise up children to Abraham even from these stones." Do you see how great his name was in everyone's estimation? For the time being, however, before the sequel the just man's God-fearing qualities are demonstrated in the way he believed the words coming from God and accepted without demur everything, difficult though it seemed.”
Source

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
ואעשך לגוי גדול AND I WILL MAKE OF THEE A GREAT NATION —Since travelling is the cause of three things—it decreases (breaks up) family life, it reduces one’s wealth and lessens one’s renown, he therefore needed these three blessings: that God should promise him children, wealth and a great name (Genesis Rabbah 39:11). ואברכך AND I WILL BLESS THEE —with wealth (Genesis Rabbah 39:11). והיה ברכה AND BE THOU A BLESSING — Blessings are entrusted to you; hitherto they were in My power — I blessed Adam and Noah — but from now on you shall bless whomsoever you wish (Genesis Rabbah 39:11) Another explanation is: AND I WILL MAKE THEE A GREAT NATION, this alludes to the fact that we say in our prayer “God of Abraham”; AND I WILL BLESS THEE — that we say, “God of Isaac”; AND I WILL MAKE THY NAME GREAT — that we say, “God of Jacob”. One might think that we should conclude the benediction in which these invocations are recited by mentioning again the names of all the patriarchs — the text therefore states “Be thou a blessing” meaning, with you (i.e. with your name only) shall they conclude the benediction and not with them (their names) (Pesachim 117b). מארצך FROM THY LAND — But had he not already departed from there together with his father and had reached as far as Haran (Genesis 11:31)? But thus God in effect said to him: Go still further away — leave now thy father’s house also. אשר אראך WHICH I WILL SHOW THEE — He did not reveal to him at once which land it was in order that he should hold it in high esteem and in order to reward him for complying with each and every command. Similar is, (Genesis 22:2) “Take thy son — thine only son — whom thou lovest — even Isaac”; similar is (Genesis 22:2) “upon one of the mountains which I will tell thee of”; similar is, (Jonah 3:2) “And make unto it the proclamation that I shall tell thee of” (Genesis Rabbah 39:9).”
Source
1270
A.D.
Ramban Jewish
1194–1270
“AND BE THOU A BLESSING. You will be the blessing by whom people will be blessed, saying, “G-d make thee as Abraham.” To this He added that all families of the earth will cite him in blessing, not just the people of his country alone. It may be that the expression, And in thee shall all the families of the earth be blessed, means that they will all be blessed on his account. Now this portion of Scripture is not completely elucidated. What reason was there that the Holy One, blessed be He, should say to Abraham, “Leave your country, and I will do you good in a completely unprecedented measure,” without first stating that Abraham worshipped G-d or that he was a righteous man, [and] perfect? Or it should state as a reason for his leaving the country that the very journey to another land constituted an act of seeking the nearness of G-d. The custom of Scripture is to state, “Walk before Me, and hearken to My voice, and I will do good unto you,” as is the case with David and Solomon,, 3:13-14. as well as throughout the Torah: If ye walk in My statute; And it shall come to pass, if thou shalt hearken diligently unto the voice of the Eternal thy G-d. And in the case of Isaac, it says, For My servant Abraham’s sake. But there is no reason for G-d to promise [Abraham a reward merely] for his leaving the country. However, the reason [for G-d’s promising Abraham this reward] is that the people of Ur of the Chaldees did him much evil on account of his belief in the Holy One, blessed be He, and he fled from them to go to the land of Canaan, tarrying for a time at Haran, whereupon the Eternal told him to leave these places as well and to fulfill his original intention that his worship be dedicated to Him alone and that he call upon people [for the worhip of] the Name of the Eternal in the Chosen Land. There He would make his name great, and these nations would bless themselves by him, not as they treated him in Ur of the Chaldees, where they abused and cursed him, put him in prison or in the fiery furnace. He further told Abraham that He will bless those who bless him, and if some individual will curse him, he will be cursed in turn. This then is the meaning of this portion of Scripture. The Torah, however, did not want to deal at length with the opinions of idol worshippers and explain the matter between him and the Chaldeans in the subject of faith, just as it dealt briefly with the matter of the generation of Enosh, Note 280. and their thesis concerning the idol-worship which they instituted.”
Source

Reformation

c. 1500 – 1650
1550
A.D.
Sforno Jewish
c. 1475–1550
“BE A BLESSING. It is a blessing for Adonai, that (Ps. 104:31) "Adonai will rejoice in His works!," as our Sages said (Ber. 7a), "He said to me: Ishmael, My son, bless Me! I replied: May it be Thy will ... that Thy mercy may prevail over Thy other attributes." He said, if so, I will have a blessing in that you will ponder, and achieve perfection, and teach knowledge to the people.”
Source

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“And I will make of thee a great nation,.... In a literal sense, as the people of the Jews were that descended from him, and in a spiritual sense believers in all ages and of all nations, that walk in the steps of the faith of Abram, who are his children, and are blessed with him: and I will bless thee; not only with temporal blessings, but principally with spiritual ones, since Abram in person had no share of the land of Canaan; even with the adoption of children and friendship with God; with justification by the imputed righteousness of Christ, which blessedness came upon him when uncircumcised; with a large measure of faith, and every other grace; with the sanctification of the Spirit, and an increase of it until brought to perfection; and with eternal glory and happiness, a right, title, and meetness for it, and the full possession of it: and make thy name great; as it was among the Jews his descendants, who boasted of having Abram for their father; and among the several nations of the world; his name is famous in profane history, and is in high esteem with the Mahometans to this day; and especially his name is great and famous, and the memory of him precious among all those who have obtained like precious faith with him, in every age and in every nation: and thou shall be a blessing; to all that knew him and conversed with him, they receiving spiritual light and knowledge by means of his instruction, and to all that should hear and read of his faith and piety, being encouraged by his example: or, "shall be blessing"; blessing itself, that is, most blessed, exceedingly blessed; as a very wicked man may be called wickedness itself; as "scelus" for "scelestus" with the Latins; so a good man may be called blessing itself, extremely happy.”
Source
1832
A.D.
Adam Clarke Methodist
1762–1832
“I will make of thee a great nation - i.e., The Jewish people; and make thy name great, alluding to the change of his name from Abram, a high father, to Abraham, the father of a multitude.”
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.