The interpretation timeline
Genesis 4:11 Douay-Rheims

Now, therefore, cursed shalt thou be upon the earth, which hath opened her mouth and received the blood of thy brother at thy hand.

A.D. 45 – 1875 7 witnesses

Patristic

before A.D. 750
45
A.D.
c. 15 B.C.–A.D. 45
“XXVII. And as to the manner in which the mind becomes accursed upon the earth, he adds further information immediately afterwards, saying : " The earth which opened her mouth to receive the blood of thy brother." For it is very difficult for the mouths of the outward senses to be opened and widened, as even when they are not open the flood of the objects appreciable only by them rushes in like an overflowing river, nothing being capable of resisting their evident impetuosity ; for then the mind is found to be overwhelmed, being wholly absorbed by so vast a wave, and being utterly unable to swim against it, or even to raise its head above it ; but it is necessary to employ all these things not so much for whatever objects can possibly be effected, but for those that are best ; for the sight can perceive all colours and all shapes ; but still it ought to behold only things worthy of light, and not of darkness. Again, the ear can receive all kinds of sounds ; but some it ought to disregard ; for myriads of the things that are said are disgraceful. Nor, 0 foolish and arrogant man, because nature has given you the faculty of taste, ought you to fill yourself insatiably with everything, like a cormorant ; for there are many things not merely among such as are nutritious, but of those which are exceedingly so, which have, nevertheless, produced diseases accompanied with great suffering. Nor does it follow that, because for the sake of the perpetuation of your race you have been endowed with the powers of generation, you ought to pursue pollutions and adulteries and other impure connections ; but only such as, in a legitimate manner, engender and propagate the race of mankind. Nor, because you have been made endowed with a mouth and a tongue and the organs of speech, ought you to say everything and to reveal what ought not to be spoken, for there are times when to hold one's peace is useful. And, in my opinion, these who have learnt to speak have also learnt to be silent, the same capacity teaching a man both lines of conduct. But those men who relate what they ought not, do not display the faculty of eloquence, but the weakness of their faculty of silence. On which account we labour to bind each of the mouthpieces of the senses before-mentioned with the imperishable bonds of temperance. " For whatever is not bound with a bond," says Moses, in another passage, "is impure," as if the cause of its unhappiness was the fact of the parts of the soul being relaxed and open and dissolved ; but that the fact of their being compacted and tightly bound together contributed to goodness and soundness of life and reason. He, therefore, curses the godless and impious Cain with deserved curses ; because, having opened the caverns of this concrete creature, he opened his mouth for all external things, praying to receive them in an insatiable manner and to contain them, to the utter destruction of the God-loving doctrine, Abel.”
Source
407
A.D.
John Chrysostom Patristic
A.D. 347–407
“You see, since Cain perpetrated practically the same evil as the serpent, which like an instrument served the devil's purposes, and as the serpent introduced mortality by means of deceit, in like manner Cain deceived his brother, led him out into open country, raised his hand in armed assault against him and committed murder. Hence, as God said to the serpent, "Cursed are you beyond all the wild animals of the earth," so to Cain too when he committed the same evil as the serpent.”
Source

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
ארור אתה מן האדמה CURSED BE THOU FROM THE GROUND or, MORE THAN THE GROUND — More than the ground has already been cursed on account of its sin (cf. Rashi on Genesis 1:11): in this, too, it has again sinned אשר פצתה את פיה לקחת את דמי אחיך IN THAT IT HATH OPENED ITS MOUTH TO TAKE THY BROTHER’S BLOOD: therefore do I impose upon it an additional curse regarding you—“it shall not henceforth yield unto thee its strength”.”
Source
1270
A.D.
Ramban Jewish
1194–1270
“CURSED ART THOU FROM THE GROUND — more than it has already been cursed on account of its sin. In this, too, it has further sinned in that it hath opened its mouth to take thy brother’s blood. Therefore, I impose upon it an additional curse: it shall not continue to give unto thee her strength. Thus the words of Rashi. But this is not correct since here He did not curse the ground because of him as He did in the case of his father, rather He said that he be cursed through the ground. The explanation of the curse is that the earth shall not continue to give him its strength, and that he be a fugitive and a wanderer in it, and He further stated, “When thou tillest the ground with all your efforts to cultivate it properly by plowing and hoeing, and in all manner of service in the field and by properly sowing it, it shall not continue to give unto thee her strength. Instead, you will sow much and harvest little.” This then was the curse, in the same sense as in the verse: And I will curse your blessings. Thus He uttered the curse in connection with his occupation for he was a tiller of the ground, and so He cursed his work. This then is the sense of the expression, it shall not continue to give unto thee her strength, meaning, “It will no longer yield to you its full produce as it had done till now when you cultivated it.” And so did Rabbi Abraham ibn Ezra explain it. It is possible that He also cursed him though the ground in that it should no longer yield its strength to him of its own accord; the fig-tree and the vine would not yield their strength in his estate, and the trees of the field would not yield him their fruit. Then He added, “Even when you work the ground by plowing and sowing, it will not continue to give you its strength as before.” Thus there were two curses relating to his occupation, and a third one — that he be a fugitive and a wanderer in the world. This means that his heart will not be at rest, and he will lack the tranquility to remain in one place on the earth; he will wander forever for the punishment of murderers is exile. The expression in that it hath opened its mouth to take thy brother’s blood means: “You have killed your brother and covered his blood with the earth, and I will decree upon it that it uncover its blood, and she shall no more cover her slain for it will be punished together with all that is covered up in it, such as seed and plant.” This is the punishment for all blood-letting on the earth, even as it is written, For blood, it polluteth the land. The pollution of the land consists of a curse upon its produce, as it is written: When one came to a heap of twenty measures, there were but ten; when one came to the wine vat to draw out fifty press-measures, there were but twenty.”
Source

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“When thou tillest the ground,.... Which was the business he was brought up in and followed, Gen 4:2. it shall not henceforth yield unto thee her strength; the earth had been cursed for Adam's sin, and was not so fruitful as in its original state; and now it was cursed again for Cain's sin; not the whole earth, but that part which belonged to Cain, and was cultivated by him; and so it must be supposed to be cursed, not only in the spot where he had been settled, but in every other place where he should come and occupy, and which through this additional curse became so barren that it did not yield such good fruits, and such an increase of it as before; it lost its native and vital juice, by which seed cast into it became not so fruitful, and did not increase; but instead of this, though much pains were taken to manure it, and much was sown, yet it brought forth little, at least but little to Cain, whatever it did to others; and therefore it is said, "shall not yield unto thee"; it would not turn much to his account, or yield much profit and increase to him, or bring forth much fruit; see Job 31:38. a fugitive and a vagabond shalt thou be in the earth; being obliged to quit his former habitation, and remove to a place at some distance from the house of his father Adam, which was near the garden of Eden, as Aben Ezra observes; and to wander about from place to place, having no quiet settlement in anyone place: the Septuagint render it "groaning and trembling"; the guilt of his sin lay heavy on his conscience, and filled him with such horror and terror that he was continually sighing and groaning, and was seized with such a tremor that he shook in all his limbs; so the Arabic writers (t) say, that he was trembling and quivering, and had a shaking in his head all the days of his life; and Aben Ezra observes, that there are some that say that the first of these words signifies to moan and lament; but it may be, it was not so much his sin, at least the evil of it, that he lamented, as the mischief that came by it, or the calamities and misfortunes it brought upon him. (t) Patricides, apud Hottinger. Smegma Oriental. l. 1. c. 8. p. 223.”
Source
1871
A.D.
1871
“now art thou cursed from the earth--a curse superadded to the general one denounced on the ground for Adam's sin.”
1875
A.D.
Keil & Delitzsch Lutheran
1861–1875
“"And now (sc., because thou hast done this) be cursed from the earth." From: i.e., either away from the earth, driven forth so that it shall no longer afford a quiet resting-place (Gerlach, Delitzsch, etc.), or out of the earth, through its withdrawing its strength, and thus securing the fulfilment of perpetual wandering (Baumgarten, etc.). It is difficult to choose between the two; but the clause, "which hath opened her mouth," etc. seems rather to favour the latter. Because the earth has been compelled to drink innocent blood, it rebels against the murderer, and when he tills it, withdraws its strength, so that the soil yields no produce; just as the land of Canaan is said to have spued out the Canaanites, on account of their abominations (Lev 18:28). In any case, the idea that "the soil, through drinking innocent blood, became an accomplice in the sin of murder," has no biblical support, and is not confirmed by Isa 26:21 or Num 35:33. The suffering of irrational creatures through the sin of man is very different from their participating in his sin. "A fugitive and vagabond (ונד נע, i.e., banished and homeless) shalt thou be in the earth." Cain is so affected by this curse, that his obduracy is turned into despair, "My sin," he says in Gen 4:13, "is greater than can be borne." עון נשׁא signifies to take away and bear sin or guilt, and is used with reference both to God and man. God takes guilt away by forgiving it (Exo 34:7); man carries it away and bears it, by enduring its punishment (cf. Num 5:31). Luther, following the ancient versions, has adopted the first meaning; but the context sustains the second: for Cain afterwards complains, not of the greatness of the sin, but only of the severity of the punishment. "Behold, Thou hast driven me out this day from the face of the earth, and from Thy face shall I be hid;...and it shall come to pass that every one that findeth me shall slay me." The adamah, from the face of which the curse of Jehovah had driven Cain, was Eden (cf. Gen 4:16), where he had carried on his agricultural pursuits, and where God had revealed His face, i.e., His presence, to the men after their expulsion from the garden; so that henceforth Cain had to wander about upon the wide world, homeless and far from the presence of God, and was afraid lest any one who found him might slay him. By "every one that findeth me" we are not to understand omnis creatura, as though Cain had excited the hostility of all creatures, but every man; not in the sense, however, of such as existed apart from the family of Adam, but such as were aware of his crime, and knew him to be a murderer. For Cain is evidently afraid of revenge on the part of relatives of the slain, that is to say, of descendants of Adam, who were either already in existence, or yet to be born. Though Adam might not at this time have had "many grandsons and great-grandson," yet according to Gen 4:17 and Gen 5:4, he had undoubtedly other children, who might increase in number, and sooner or later might avenge Abel's death. For, that blood shed demands blood in return, "is a principle of equity written in the heart of every man; and that Cain should see that earth full of avengers is just like a murderer, who sees avenging spirits (Ἐρινύες) ready to torture him on every hand."”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.