The interpretation timeline
Genesis 4:25 Douay-Rheims

Adam also knew his wife again: and she brought forth a son, and called his name Seth, saying: God hath given me another seed, for Abel whom Cain slew.

A.D. 45 – 1875 9 witnesses 11 excerpts

Patristic

before A.D. 750
45
A.D.
c. 15 B.C.–A.D. 45
“XVI. And one may wonder at the kind of narration which the Jewish lawgiver frequently employs in many instances, where he departs from the usual style. For after giving the history of those parents of the human race who were created out of the earth, he begins to relate the story of the first-born of human parents, concerning whom he says absolutely nothing, as if he had already frequently mentioned his name, and were not now bringing it forward for the first time. Accordingly, he simply says that " she brought forth Cain." What sort of being was he, 0 writer ; and what have you ever said about him before of either great or small importance ? And yet you are not ignorant of the importance of a proper application of Genesis xviii. 11. OF CAIN AND HIS BIRTH. 189 Dames. For before this time, as you proceed in your history, you show this, when speaking in reference to the same person you say, " And Adam knew Eve his wife, and she conceived and brought forth a son, and she called his name Seth." Therefore it was much more necessary in the case of the firstborn, who was the beginning of the generation of men from one another, to display the nature of him who was thus conceived and born, in the first place showing that he was a male child, and secondly mentioning his peculiar name, Cain. Since, therefore, it was not owing to inexperience or to ignorance of according to what persons he ought to give names, that he appears to have discarded his usual practice in the case of Cain, we must now consider on what account he thus named those who were born of our first parents, rather mentioning the name in an incidental way than actually giving it. And the cause, as it appears to me, according to the best conjecture that I can form, is this.”
Source
“XXXVI. Therefore, concerning the wives of Lamech and his children, I think that enough has been said. Let us now consider what we may look upon as the resurrection of Abel, who was treacherously slain. Moses tells us, " And Adam knew his wife Eve, and she conceived and brought forth a son, and he called his name Seth ; for, said he, " God has raised me up another seed instead of Abel, whom Cain slew."§ The interpretation of the name Seth, is " irrigation." As, therefore, the seeds and plants which are put into the ground grow and blossom through being irrigated, and are thus made fertile for the production of fruits, Deuteronomy xxxii. 15. + Numbers xiv. 9. £ Leviticus iii." 16. § Genesis iv. 2 5. 1 5 but if they are deprived of moisture they wither away, so likewise the soul, as it appears when it is watered with the wholesome stream of wisdom, shoots forth, and brings fruit to perfection. Now, irrigation may be looked upon in a' two -fold light : with regard to that which irrigates, and with regard to that which is irrigated. And might one not say that each of the outward senses is irrigated by the mind as by a fountain, which widens and extends all their faculties, as if they were so many channels for water ? No one, therefore, in his senses would say, that the eyes see, but that the mind sees by means of the eyes ; or that the ears hear, but that the mind hears by the instrumentality of the ears ; or that the nostrils smell, but that the predominant part of man smells through the medium of the nostrils.”
Source
“XLIX. Therefore the mind having generated the foundation of good .... | and the primary principle of virtue, namely Seth, or irrigation, boasts with an honourable and holy boast ; for she says, " God has raised up to me another seed, instead of Abel whom Cain slew, "J for it has been said with great exactness and neatness, that no single divine seed ever falls to the ground, but that they all rise up from the things of earth, and leave them, and are borne upwards to heaven ; but the seeds which are sown by mortals, whether for the generation of animals or of plants, do not all come to perfection ; but we must be content if more are not wasted than those which remain above ; and God sows nothing in our souls which is incomplete ; but his seed is all so seasonable and so perfect that every one of them is at once borne forward to produce abundance of its appropriate fruit.”
Source
215
A.D.
c. A.D. 150–215
“We agree that weakness of will and sexual immorality are passions inspired by the devil. But the harmony of responsible marriage occupies a middle position. When there is self-control, it leads to prayer; when there is reverent bridal union, to childbearing. At any rate, there is a proper time for the breeding of children, and Scripture calls it knowledge, in the words "Adam knew his wife Eve, and she conceived and bore a son, and called him by the name of Seth, 'for God has raised up for me another child in Abel's place.' "”
Source
430
A.D.
Augustine of Hippo Patristic
A.D. 354–430
“It is quite possible that when Adam was divinely inspired to say, after Seth was born, "God has given me another seed, for Abel whom Cain slew," there is no implication here that Seth was the next born in the order of time but only that he was destined to be a fit heir in the order of holiness.”
date
unknown
c. A.D. 550
“And when she had conceived, she bare a son and called his name Sêth, for, said she, God hath raised me up another seed instead of Abel whom Cain slew; implying by this that Abel has died childless, and the seed of Cain is to perish; this hath God given me as a new foundation for the human race. So far Eve.”

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
וידע אדם AND ADAM KNEW — Lamech came to Adam Harishon, complaining about his wives. He (Adam) said to them: “Is it for you to be overparticular regarding God’s decrees? You do your duty, and He will do His!” They replied to him: “First correct yourself: have you not lived apart from your wife these 130 years, ever since, through you, death was decreed as a punishment?” At once ‘וידע אדם עוד וגו “Adam knew his wife עוד ” — What signifies the word עוד? It is used here to teach that his love for her was now greater than before (Genesis Rabbah 23:4-5).”
Source

Post-Reformation

c. 1650 – 1900
1714
A.D.
Matthew Henry Reformed
1662–1714
“This is the first mention of Adam in the story of this chapter. No question, the murder of Abel, and the impenitence and apostasy of Cain, were a very great grief to him and Eve, and the more because their own wickedness did now correct them and their backslidings did reprove them. Their folly had given sin and death entrance into the world; and now they smarted by it, being, by means thereof, deprived of both their sons in one day, Gen 27:45. When parents are grieved by their children's wickedness they should take occasion thence to lament that corruption of nature which was derived from them, and which is the root of bitterness. But here we have that which was a relief to our first parents in their affliction. I. God gave them to see the re-building of their family, which was sorely shaken and weakened by that sad event. For, 1. They saw their seed, another seed instead of Abel, Gen 4:25. Observe God's kindness and tenderness towards his people, in his providential dealings with them; when he takes away one comfort from them, he gives them another instead of it, which may prove a greater blessing to them than that was in which they thought their lives were bound up. This other seed was he in whom the church was to be built up and perpetuated, and he comes instead of Abel, for the succession of confessors is the revival of the martyrs and as it were the resurrection of God's slain witnesses. Thus we are baptized for the dead (Co1 15:29), that is, we are, by baptism, admitted into the church, for or instead of those who by death, especially by martyrdom, are removed out of it; and we fill up their room. Those who slay God's servants hope by this means to wear out the saints of the Most High; but they will be deceived. Christ shall still see his seed; God can out of stones raise up children for him, and make the blood of the martyrs the seed of the church, whose lands, we are sure, shall never be lost for want of heirs. This son, by a prophetic spirit, they called Seth (that is, set, settled, or placed), because, in his seed, mankind should continue to the end of time, and from him the Messiah should descend. While Cain, the head of the apostasy, is made a wanderer, Seth, from whom the true church was to come, is one fixed. In Christ and his church is the only true settlement. 2. They saw their seed's seed, Gen 4:26. To Seth was born a son called Enos, that general name for all men, which bespeaks the weakness, frailty, and misery, of man's state. The best men are most sensible of these, both in themselves and their children. We are never so settled but we must remind ourselves that we are frail. II. God gave them to see the reviving of religion in their family: Then began men to call upon the name of the Lord, Gen 4:26. It is small comfort to a good man to see his children's children, if he do not, withal, see peace upon Israel, and those that come of him walking in the truth. Doubtless God's name was called upon before, but now, 1. The worshippers of God began to stir up themselves to do more in religion than they had done; perhaps not more than had been done at first, but more than had been done of late, since the defection of Cain. Now men began to worship God, not only in their closets and families, but in public and solemn assemblies. Or now there was so great a reformation in religion that it was, as it were, a new beginning of it. Then may refer, not to the birth of Enos, but to the whole foregoing story: then, when men saw in Cain and Lamech the sad effects of sin by the workings of natural conscience, - when they saw God's judgments upon sin and sinners, - then they were so much the more lively and resolute in religion. The worse others are the better we should be, and the more zealous. 2. The worshippers of God began to distinguish themselves. The margin reads it, Then began men to be called by the name of the Lord, or to call themselves by it. Now that Cain and those that had deserted religion had built a city, and begun to declare for impiety and irreligion, and called themselves the sons of men, those that adhered to God began to declare for him and his worship, and called themselves the sons of God. Now began the distinction between professors and profane, which has been kept up ever since, and will be while the world stands.”
Source
1832
A.D.
Adam Clarke Methodist
1762–1832
“God - hath appointed me another seed instead of Abel - Eve must have received on this occasion some Divine communication, else how could she have known that this son was appointed in the place of Abel, to continue that holy line by which the Messiah was to come? From this we see that the line of the Messiah was determined from the beginning, and that it was not first fixed in the days of Abraham; for the promise was then only renewed, and that branch of his family designated by which the sacred line was to be continued. And it is worthy of remark, that Seth's posterity alone continued after the flood, when all the other families of the earth were destroyed, Noah being the tenth descendant from Adam through Seth. Though all these persons are mentioned in the following chapter, I shall produce them here in the order of their succession: 1. Adam; 2. Seth; 3. Enos; 4. Cainan; 5. Mahalaleel; 6. Jared; 7. Enoch; 8. Methuselah; 9. Lamech, (the second); 10. Noah. In order to keep this line distinct, we find particular care was taken that, where there were two or more sons in a family, the one through whom God particularly designed to bring his Son into the world was, by some especial providence, pointed out. Thus in the family of Adam, Seth was chosen; in the family of Noah, Shem; in the family of Abraham, Isaac; and in that of David, Solomon and Nathan. All these things God watched over by an especial providence from the beginning, that when Jesus Christ should come it might be clearly seen that he came by the promise, through grace, and not by nature.”
Source
1863
A.D.
1796–1863
“Lit. " For Cain slew him." The repeated use of the causal particle marks the simplicity of ancient style.”
1875
A.D.
Keil & Delitzsch Lutheran
1861–1875
“The character of the ungodly family of Cainites was now fully developed in Lamech and his children. The history, therefore, turns from them, to indicate briefly the origin of the godly race. After Abel's death a third son was born to Adam, to whom his mother gave the name of Seth (שׁת, from שׁית, a present participle, the appointed one, the compensation); "for," she said, "God hath appointed me another seed (descendant) for Abel, because Cain slew him." The words "because Cain slew him" are not to be regarded as an explanatory supplement, but as the words of Eve; and כּי by virtue of the previous תּחת is to be understood in the sense of כּי תּחת. What Cain (human wickedness) took from her, that has Elohim (divine omnipotence) restored. Because of this antithesis she calls the giver Elohim instead of Jehovah, and not because her hopes had been sadly depressed by her painful experience in connection with the first-born. Gen 4:26 "To Seth, to him also (הוּא גּם, intensive, vid., Ges. 121, 3) there was born a son, and he called his name Enosh." אנושׁ, from אנשׁ to be weak, faint, frail, designates man from his frail and mortal condition (Psa 8:4; Psa 90:3; Psa 103:15, etc.). In this name, therefore, the feeling and knowledge of human weakness and frailty were expressed (the opposite of the pride and arrogance displayed by the Canaanitish family); and this feeling led to God, to that invocation of the name of Jehovah which commenced under Enos. יהוה בּשׁם קרא, literally to call in (or by) the name of Jehovah, is used for a solemn calling of the name of God. When applied to men, it denotes invocation (here and Gen 12:8; Gen 13:4, etc.); to God, calling out or proclaiming His name (Exo 33:19; Exo 34:5). The name of God signifies in general "the whole nature of God, by which He attests His personal presence in the relation into which He has entered with man, the divine self-manifestation, or the whole of that revealed side of the divine nature, which is turned towards man" (Oehler). We have here an account of the commencement of that worship of God which consists in prayer, praise, and thanksgiving, or in the acknowledgment and celebration of the mercy and help of Jehovah. While the family of Cainites, by the erection of a city, and the invention and development of worldly arts and business, were laying the foundation for the kingdom of this world; the family of the Sethites began, by united invocation of the name of God of grace, to found and to erect the kingdom of God.”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.