The interpretation timeline
Genesis 49:3 Douay-Rheims

Ruben, my firstborn, thou art my strength, and the beginning of my sorrow: excelling in gifts, greater in command.

A.D. 235 – 1875 9 witnesses

Patristic

before A.D. 750
235
A.D.
Hippolytus of Rome Patristic
c. A.D. 170–235
“For there was a great display of strength made by God in behalf of His first-born people from Egypt. For in very many ways was the land of the Egyptians chastised. That first people of the circumcision is meant by "my strength, and the first of my children: "even as God gave the promise to Abraham and to his seed. But "hard to bear with," because the people hardened itself against the obedience of God. And "hard, self-willed," because it was not only hard against the obedience of God, but also self-willed so as to set upon the Lord. "Thou hast waxed wanton," because in the instance of our Lord Jesus Christ the people waxed wanton against the Father. But "boil not over," says the Spirit, by way of comfort, that it might not, by boiling utterly over, be spilt abroad,-giving it hope of salvation. For what has boiled over and been spilt is lost.”
Source
407
A.D.
John Chrysostom Patristic
A.D. 347–407
“See the extent of the good man's wisdom. Intending to level a worse accusation against Reuben, he first mentioned the privileges conceded him by nature and the precedence he enjoyed in being the beginning of his line and enjoying the dignity of firstborn. Then he records his sins of free will as if on a bronze pillar to show that no advantage comes to us from natural advantage unless accompanied by good deeds of free will—these, you see, are what bring us commendation or lend us the stigma of blame. "Unyielding in endurance," he says, "unyielding in willfulness": the pride of place accorded you by nature you have forfeited by your own headstrong behavior.”
Source
411
A.D.
Tyrannius Rufinus Patristic
c. A.D. 345–411
“It seems to me that, according to the mystical interpretation, Reuben may play the role of the first Jewish people, that is, the firstborn and the beginning of the children, as the prophet says: "Israel is my firstborn." The words of God in fact were first addressed to that people. And the Scriptures relate that that people was hard and reckless. About whom the prophet says, "Whatsoever this people says, is hard." Elsewhere he says again about the Jews, "You stiff-necked people, uncircumcised in heart." And these people offended God the Father when they turned their back to him and not their face. They defiled the concubine's bed into which they got, that is, the law of the Old Testament, which they often stained with their transgressions. Paul teaches us that the concubine symbolically represents the law of the Old Testament by saying, "Abraham had two sons, one by a slave and one by a free woman: these are the two Testaments"; and Hagar, who was the concubine, clearly is the figure of the Old Testament.One indeed was the perfect dove or mother, the church that, as a chaste virgin and as a queen for her bridegroom the king, is united through the gospel to Christ.”
Source

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
אוני means MY VIGOUR, as (Hosea 12:9) “I have gained me (און) strength”; (Isaiah 40:26) “by the greatness of His (אונים) might”; (Isaiah 5:29) “and to him that hath no (אונים) might Ho increaseth strength”. יתר שאת SUPERIORITY IN DIGNITY — Since you were the first-born it was proper that you should be superior to your brothers by being endowed with the priesthood. This term שאת “lifting up” alludes to the נשיאות כפים the raising of the hands when the priests pronounce the benediction (Genesis Rabbah 98:4; cf. Onkelos). ויתר עז SUPERIORITY IN POWER — meaning in royal rank, as is meant by עז in (1 Samuel 2:10) “And he will give strength (עז) unto His king”. And what caused you to lose all these?”
Source
1270
A.D.
Ramban Jewish
1194–1270
“REUBEN MY FIRSTBORN THOU ART.. Ramban will transpose the order of the words for the purpose of deriving the meaning of the verse. The sequence of this verse is, “Reuben, thou art my firstborn, my might, and the first-fruits of my strength, the excellence of majesty, and the excellence of power,” and its purport is as follows: “You are the first-born of my might and the first-fruits of my strength when I was the excellence of majesty (se’eith) and position” — the expression being similar to that found in the verses: Shall not his excellency (‘se’eitho’) make you afraid? When he raiseth himself up (‘mise’eitho’) the mighty are afraid,, 41:17. ‘mise’eitho’ meaning ascendancy and power — “and when I was at the height of strength (oz) for war” — the expression being similar to that found in the verses: And He will give strength (‘oz’) unto His king; And the strength (‘ve’izuz’) of battle.”
Source

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“Reuben, thou art my firstborn,.... Jacob addressed himself to Reuben first, in the presence of his brethren, owned him as his firstborn, as he was, Gen 29:31 did not cashier him from his family, nor disinherit him, though he had greatly disobliged him, for which the birthright, and the privileges of it, were taken from him, Ch1 5:1. my might, and the beginning of my strength; begotten by him when in his full strength (z), as well as the first of his family, in which his strength and glory lay; so the Septuagint, "the beginning of my children"; and because he was so, of right the double portion belonged to him, had he not forfeited it, Deu 21:17. Some versions render the words, "the beginning of my grief", or "sorrow" (a), the word "Oni" sometimes so signifying, as Rachel called her youngest son "Benoni", the son of my sorrow; but this is not true of Reuben, he was not the beginning of Jacob's sorrow, for the ravishing of Dinah, and the slaughter and spoil of the Shechemites, by his sons, which gave him great sorrow and grief, were before the affair of Reuben's lying with Bilhah: the excellency of dignity, and the excellency of power; that is, to him of right belonged excellent dignity, power, and authority in the family, a preeminence over his brethren, a double portion of goods, succession in government, and, as is commonly understood, the exercise of the priesthood; and so the Targums interpret it, that he should, had he not sinned, took three parts or portions above his brethren, the birthright, priesthood, and kingdom. Jacob observes this to him, that he might know what he had lost by sinning, and from what excellency and dignity, grandeur and power, he was fallen. (z) "Nate. meae vires. --------" Virgil. (a) , Aquila; , Symmachus apud Drusium; "principium doloris mei", V. L. Tigurine version.”
Source
1832
A.D.
Adam Clarke Methodist
1762–1832
“Reuben as the first-born had a right to a double portion of all that the father had; see Deu 21:17 The eminence or dignity mentioned here may refer to the priesthood; the power, to the regal government or kingdom - In this sense it has been understood by all the ancient Targumists. The Targum of Onkelos paraphrases it thus: "Thou shouldst have received three portions, the birthright, the priesthood, and the kingdom:" and to this the Targums of Jonathan ben Uzziel and Jerusalem add: "But because thou hast sinned, the birthright is given to Joseph, the kingdom to Judah, and the priesthood to Levi." That the birthright was given to the sons of Joseph we have the fullest proof from Ch1 5:1.”
Source
1849
A.D.
1774–1849
“My strength, &c. He calls him his strength, as being born whilst his father was in his full strength and vigour: he calls him the beginning of his sorrow, because cares and sorrows usually come on with the birth of children. — Excelling in gifts, &c., because the first-born had a title to a double portion, and to have the command over his brethren, which Ruben forfeited by his sin; being poured out as water; that is, spilt and lost. (Challoner) — In command. He ought to have succeeded to his father in authority. But Joseph entered in upon his rejection, 1 Paralipomenon v. 1. The priesthood was given to Levi’s descendants; and the regal power, partly to those of Joseph, who reigned over the ten tribes, for a long time; and partly to the posterity of Juda, who exercised dominion over all the people of Israel. (Chaldee) (Worthington)”
Source
1875
A.D.
Keil & Delitzsch Lutheran
1861–1875
“Reuben, my first-born thou, my might and first-fruit of my strength; pre-eminence in dignity and pre-eminence in power. - As the first-born, the first sprout of the full virile power of Jacob, Reuben, according to natural right, was entitled to the first rank among his brethren, the leadership of the tribes, and a double share of the inheritance (Gen 27:29; Deu 21:17). (שׂאת: elevation, the dignity of the chieftainship; עז, the earlier mode of pronouncing עז, the authority of the first-born.) But Reuben had forfeited this prerogative. "Effervescence like water - thou shalt have no preference; for thou didst ascend thy father's marriage-bed: then hast thou desecrated; my couch has he ascended." פּחז: lit., the boiling over of water, figuratively, the excitement of lust; hence the verb is used in Jdg 9:4; Zep 3:4, for frivolity and insolent pride. With this predicate Jacob describes the moral character of Reuben; and the noun is stronger than the verb פחזת of the Samaritan, and אתרעת or ארתעת efferbuisti, aestuasti of the Sam. Vers., ἐξύβρισας of the lxx, and ὑπερζέσας of Symm. תּותר is to be explained by יתר: have no pre-eminence. His crime was, lying with Bilhah, his father's concubine (Gen 35:22). חלּלתּ is used absolutely: desecrated hast thou, sc., what should have been sacred to thee (cf. Lev 18:8). From this wickedness the injured father turns away with indignation, and passes to the third person as he repeats the words, "my couch he has ascended." By the withdrawal of the rank belonging to the first-born, Reuben lost the leadership in Israel; so that his tribe attained to no position of influence in the nation (compare the blessing of Moses in Deu 33:6). The leadership was transferred to Judah, the double portion to Joseph (Ch1 5:1-2), by which, so far as the inheritance was concerned, the first-born of the beloved Rachel took the place of the first-born of the slighted Leah; not, however, according to the subjective will of the father, which is condemned in Deu 21:15., but according to the leading of God, by which Joseph had been raised above his brethren, but without the chieftainship being accorded to him.”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.