The interpretation timeline
Genesis 9:6 Douay-Rheims

Whosoever shall shed man’s blood, his blood shall be shed: for man was made to the image of God.

A.D. 45 – 1871 10 witnesses

Patristic

before A.D. 750
45
A.D.
c. 15 B.C.–A.D. 45
“XXXI. On which account God also calls Bezaleel by name, and says that " He will give him wisdom and knowledge, and that He will make him the builder and the architect of all the things which are in his tabernacle ;" that is to say, of all the works of the soul, when he had up to this time done no work which anyone could praise — we must say, therefore, that God impressed this figure also on the soul, after the fashion of an approved coin. And we shall know what the impression is if we previously examine the interpretation of the name. Now, Exodus xxxl 2. Bezaleel, being interpreted, means God in his shadow. But the shadow of God is his word, winch he used like an instrument when he was making the world. And this shadow, and, as it were, model, is the archetype of other things. For, as God is himself the model of that image which he has now called a shadow, so also that image is the model of other things, as he showed when he commenced giving the law to the Israelites, and said, "And God made man according to the image of God," as the image was modelled according to God, and as man was modelled according to the image, which thus received the power and character of the model.”
Source
202
A.D.
Irenaeus Patristic
c. A.D. 130–202
“And He changed the food of men, giving them leave to eat flesh: for from Adam the first-formed until the Flood men ate only of seeds and the fruit of trees, and to eat flesh was not permitted to them. But since the three sons of Noah were the beginning of a race of men, God blessed them for multiplication and increase, saying: "Increase and multiply, and replenish the earth and rule it; and the fear and dread of you shall be upon every living thing of animals and upon all the fowls of the air; and they shall be to you for meat, even as the green herb: but the flesh with the blood of life ye shall not eat: for your blood also will I requite at the hand of all beasts and at the hand of man. Whoso sheddeth a man's blood, in return for his blood shall it be shed." For He made man the image of God; and the image of God is the Son, after whose image man was made: and for this cause He appeared in the end of the times that He might show the image (to be) like unto Himself. According to this covenant the race of man multiplied, springing up from the seed of the three.”
Source
407
A.D.
John Chrysostom Patristic
A.D. 347–407
“"Whoever sheds someone's blood, his own will be shed in payment for that person's blood, because I have made the human person in God's image." Consider, I ask you, how much fear he struck in them with that remark. He is saying even if you are not restrained from murderous hands by kinship or by a sense of fellowship of nature, and even if you thrust aside all brotherly feeling and become completely committed to a bloody murder, you must think twice. Consider the fact that the person has been created in God's image. Mark the degree of honor accorded him by God! Think on the fact that he has received authority over all creation. Then you will give up your murderous intent. So what does he mean? If someone has committed countless murders and shed so much blood, how can he give adequate satisfaction simply by the shedding of his own blood? Do not have these thoughts, human being that you are. Instead you do well to consider in advance that you will receive an immortal body that will have the capacity to undergo constant and everlasting punishment.”
Source
date
unknown
c. A.D. 550
“Whoso sheddeth man's blood, by man shall his blood be shed, for in the image of God have I made man. Hence it is manifest that God, both before the transgression and long after its occurrence, gave to man the same honour and power and dominion.”
749
A.D.
John of Damascus Patristic
A.D. 676–749
“Moreover, sacred Scripture, too, testifies to the fact that there will be a resurrection of the body. Indeed, God already had said to Noah after the flood, "Even as the green herbs have I delivered them all to you: saving that flesh with blood of its life you shall not eat. And I will require your blood of your lives, at the hand of every beast I will require it. And at the hand of every man I will require the life of his brother. Whosoever shall shed man's blood, for that blood his blood will be shed: for I made man to the image of God." How can he require the blood of men at the hand of every beast, unless he raises the bodies of those who die? For beasts will not die in the place of human beings.”
Source

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
באדם דמו ישפך BY MAN SHALL HIS BLOOD BE SHED — If there are witnesses you kill him. Why? Because in the image of God [made He man] and he has destroyed the Divine image (Genesis Rabbah 34:14) עשה את האדם HE MADE MAN — This verse is abbreviated and should be “the Maker made man”; there are many similar expressions in the Scriptures.”
Source

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“Whoso sheddeth man's blood, by man shall his blood be shed,.... That is, he that is guilty of wilful murder shall surely be put to death by the order of the civil magistrate; so the Targum of Jonathan,"by witnesses the judges shall condemn him to death,''that is, the fact being clearly proved by witnesses, the judges shall condemn"him to death,''that is, the fact being clearly proved by witnesses, the judges shall pass the sentence of death upon him, and execute it; for this is but the law of retaliation, a just and equitable one, blood for blood, or life for life; though it seems to be the first law of this kind that empowered the civil magistrate to take away life; God, as it is thought, reserving the right and power to himself before, and which, for some reasons, he thought fit not to make use of in the case of Cain, whom he only banished, and suffered not others to take away his life, but now enacts a law, requiring judges to punish murder with death: and which, according to this law, ought never to go unpunished, or have a lesser punishment inflicted for it: the reason follows: for in the image of God made he man; which, though sadly defaced and obliterated by sin, yet there are such remains of it, as render him more especially the object of the care and providence of God, and give him a superiority to other creatures; and particularly this image, among others, consists in immortality, which the taking away of his life may seem to contradict; however, it is what no man has a right to do.”
Source
1832
A.D.
Adam Clarke Methodist
1762–1832
“Whoso sheddeth man's blood, by man shall his blood - Hence it appears that whoever kills a man, unless unwittingly, as the Scripture expresses it, shall forfeit his own life. A man is accused of the crime of murder; of this crime he is guilty or he is not: if he be guilty of murder he should die; if not, let him be punished according to the demerit of his crime; but for no offense but murder should he lose his life. Taking away the life of another is the highest offense that can be committed against the individual, and against society; and the highest punishment that a man can suffer for such a crime is the loss of his own life. As punishment should be ever proportioned to crimes, so the highest punishment due to the highest crime should not be inflicted for a minor offense. The law of God and the eternal dictates of reason say, that if a man kill another, the loss of his own life is at once the highest penalty he can pay, and an equivalent for his offense as far as civil society is concerned. If the death of the murderer be the highest penalty he can pay for the murder he has committed, then the infliction of this punishment for any minor offense is injustice and cruelty; and serves only to confound the claims of justice, the different degrees of moral turpitude and vice, and to render the profligate desperate: hence the adage so frequent among almost every order of delinquents, "It is as good to be hanged for a sheep as a lamb;" which at once marks their desperation, and the injustice of those penal laws which inflict the highest punishment for almost every species of crime. When shall a wise and judicious legislature see the absurdity and injustice of inflicting the punishment of death for stealing a sheep or a horse, forging a twenty shillings' note, and Murdering A Man; when the latter, in its moral turpitude and ruinous consequences, infinitely exceeds the others?* (* On this head the doctor's pious wish has been realized since this paragraph was written. - Publishers)”
Source
1849
A.D.
1774–1849
“Shed. God had not subjected Cain to this law of retaliation, as he was the first murderer, and the earth was unpeopled. (Haydock) — Here he declares, that it is just to inflict such a punishment on the offender. (Menochius) — Judges are hence authorized to punish murderers with death. (Calmet) — The general law, thou shalt not kill, admits of exceptions, and forbids killing by private authority, or out of revenge. (Haydock) — The blood of your lives, may signify the blood on which your life depends; or, according to the Rabbin, it is a prohibition of suicide, which one would think is so contrary to the first law of nature, self-preservation, as to require no prohibition; and yet, to the scandal of philosophers, some have written in its defence! (Haydock)”
Source
1871
A.D.
1871
“Whoso sheddeth man's blood . . . for in the image of God made he man--It is true that image has been injured by the fall, but it is not lost. In this view, a high value is attached to the life of every man, even the poorest and humblest, and an awful criminality is involved in the destruction of it.”
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.