The interpretation timeline
James 1:21 Douay-Rheims

Wherefore casting away all uncleanness, and abundance of naughtiness, with meekness receive the ingrafted word, which is able to save your souls.

A.D. 165 – 1871 5 witnesses

Patristic

before A.D. 750
165
A.D.
Justin Martyr Patristic
A.D. 100–165
“For I myself, when I discovered the wicked disguise which the evil spirits had thrown around the divine doctrines of the Christians, to turn aside others from joining them, laughed both at those who framed these falsehoods, and at the disguise itself, and at popular opinion; and I confess that I both boast and with all my strength strive to be found a Christian; not because the teachings of Plato are different from those of Christ, but because they are not in all respects similar, as neither are those of the others, Stoics, and poets, and historians. For each man spoke well in proportion to the share he had of the spermatic word, seeing what was related to it. But they who contradict themselves on the more important points appear not to have possessed the heavenly wisdom, and the knowledge which cannot be spoken against. Whatever things were rightly said among all men, are the property of us Christians. For next to God, we worship and love the Word who is from the unbegotten and ineffable God, since also He became man for our sakes, that becoming a partaker of our sufferings, He might also bring us healing. For all the writers were able to see realities darkly through the sowing of the implanted word that was in them. For the seed and imitation impacted according to capacity is one thing, and quite another is the thing itself, of which there is the participation and imitation according to the grace which is from Him.”
Source

Post-Reformation

c. 1650 – 1900
1832
A.D.
Adam Clarke Methodist
1762–1832
“All filthiness - Πασαν ῥυπαριαν. This word signifies any impurity that cleaves to the body; but applied to the mind, it implies all impure and unholy affections, such as those spoken of Jam 1:15, which pollute the soul; in this sense it is used by the best Greek writers. Superfluity of naughtiness - Περισσειαν κακιας· The overflowing of wickedness. Perhaps there is an allusion here to the part cut off in circumcision, which was the emblem of impure desire; and to lessen that propensity, God, in his mercy, enacted this rite. Put all these evil dispositions aside, for they blind the soul, and render it incapable of receiving any good, even from that ingrafted word of God which otherwise would have saved their souls. The ingrafted word - That doctrine which has already been planted among you, which has brought forth fruit in all them that have meekly and humbly received it, and is as powerful to save your souls as the souls of those who have already believed. I think this to be the meaning of εμφυτον λογον, the ingrafted word or doctrine. The seed of life had been sown in the land; many of them had received it to their salvation; others had partially credited it, but not so as to produce in them any saving effects. Besides, they appear to have taken up with other doctrines, from which they had got no salvation; he therefore exhorts them to receive the doctrine of Christ, which would be the means of saving them unto eternal life. And when those who were Jews, and who had been originally planted by God as altogether a right vine, received the faith of the Gospel, it is represented as being ingrafted on that right stock, the pure knowledge of the true God and his holy moral law. This indeed was a good stock on which to implant Christianity. This appears to be what the apostle means by the ingrafted word, which is able to save the soul.”
Source
1849
A.D.
1774–1849
“All uncleanness. [8] The Greek shews that hereby is meant a sordid, filthy uncleanness, infecting and defiling the soul. — The engrafted [9] word. The word and doctrine of Christ, by the labours of his preachers, and chiefly by his divine grace engrafted and fixed in your souls. (Witham)”
1871
A.D.
1871
“lay apart--"once for all" (so the Greek): as a filthy garment. Compare Joshua's filthy garments, Zac 3:3, Zac 3:5; Rev 7:14. "Filthiness" is cleansed away by hearing the word (Joh 15:3). superfluity of naughtiness--excess (for instance, the intemperate spirit implied in "wrath," Jam 1:19-20), which arises from malice (our natural, evil disposition towards one another). Pe1 2:1 has the very same words in the Greek. So "malice" is the translation, Eph 4:31; Col 3:8. "Faulty excess" [BENGEL] is not strong enough. Superfluous excess in speaking is also reprobated as "coming of evil" (the Greek is akin to the word for "naughtiness" here) in the Sermon on the Mount (Mat 5:37), with which James' Epistle is so connected. with meekness--in mildness towards one another [ALFORD], the opposite to "wrath" (Jam 1:20): answering to "as new-born babes" (Pe1 2:2). Meekness, I think, includes also a childlike, docile, humble, as well as an uncontentious, spirit (Psa 25:9; Psa 45:4; Isa 66:2; Mat 5:5; Mat 11:28-30; Mat 18:3-4; contrast Rom 2:8). On "receive," applied to ground receiving seed, compare Mar 4:20. Contrast Act 17:11; Th1 1:6 with Th2 2:10. engrafted word--the Gospel word, whose proper attribute is to be engrafted by the Holy Spirit, so as to be livingly incorporated with the believer, as the fruitful shoot is with the wild natural stock on which it is engrafted. The law came to man only from without, and admonished him of his duty. The Gospel is engrafted inwardly, and so fulfils the ultimate design of the law (Deu 6:6; Deu 11:18; Psa 119:11). ALFORD translates, "The implanted word," referring to the parable of the sower (Mat. 13:1-23). I prefer English Version. able to save--a strong incentive to correct our dulness in hearing the word: that word which we hear so carelessly, is able (instrumentally) to save us [CALVIN]. souls--your true selves, for the "body" is now liable to sickness and death: but the soul being now saved, both soul and body at last shall be so (Jam 5:15, Jam 5:20).”
Source

Undated

date unknown
date
unknown
Glossa Ordinaria Medieval
“Wherefore, casting away, etc. He has admonished them to seek out doctrine; that they may receive it, and that they may be able to advance in it, he now exhorts to cleanness of body and of soul. For he who does not turn aside from evil cannot do good. The engrafted word. Which we lay upon your hearts by preaching; or the word which was engrafted and sown on the day of redemption, when God begot you; now receive it more perfectly, and fulfil in works what you hold in mystery.”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.