The interpretation timeline
Isaiah 42:16 Douay-Rheims

And I will lead the blind into the way which they know not: and in the paths which they were ignorant of I will make them walk: I will make darkness light before them, and crooked things straight: these things have I done to them, and have not forsaken them.

A.D. 461 – 1875 8 witnesses

Patristic

before A.D. 750
461
A.D.
Leo the Great Patristic
c. A.D. 400–461
“The apostle John teaches how this is fulfilled: "We know that the Son of God came and gave understanding to us, that we might know the truth and be in his true Son." And again, "Let us love, therefore, since God first loved us." By loving us, God restores us to be his image, so that he might find the form of his own goodness in us. He grants that we ourselves might work what he works, indeed setting light to our minds and causing us to burn with the fire of his love, in order that we love not only him but also the things that he loves.”
Source

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
“And I will lead the blind Israel, who were heretofore blind from looking to Me, I will lead in the good way, upon which they did not know to walk. I will do them Heb. עֲשִׂיתִם [lit. I did them], I will do. So is the language of prophecy, to speak of the future as if it was already done.”
1167
A.D.
Ibn Ezra Jewish
1089–1167
“And I will bring the blind by a way that they knew not; for even the blind, if accustomed to a path, go there without a guide. I will make darkness light before them, and crooked things straight. Some refer this to the return of the Israelites from Babylon.”
1256
A.D.
Thomas Aquinas Catholic
1225–1274
“Behold my servant, etc. Here he shows the divine love from the Son whom he promised. John 3: so God loved the world, etc. And first, from so great a benefit, he shows the love of God; second, the perversity of the Jews, "these words I did to them," etc. Concerning the first, three things. First he foretells the coming of the Son of God; second, the fall of the wicked, "the Lord like a strong man," etc. Third, the resurrection of the good, "and I will lead forth the blind," etc., Luke 2: "behold, this one is set," etc. Concerning the first, three things. First he describes the condition of the one being sent; second he foretells the mission, "thus says the Lord," etc.; third he invites to thanksgiving, "sing to the Lord," etc. Concerning the first, three things. First he shows the fullness of grace as regards the grace of union, "I will uphold him." "Servant," according to human nature. Luke 1: "he has upheld Israel," etc.; as regards the grace of headship, "elect," that he might be the head of the Church. "Out of thousands": Canticles 5. Psalm 64: "blessed is he whom you have chosen and taken up," etc., "he was well-pleasing." Matthew 3: "this is my son," etc.; as regards habitual grace, which was singular in him, "I have given my spirit." Above 11: "the spirit of the Lord shall rest upon him," etc. Second he shows the equity of judgment, as regards three things: namely the authority of judging, "judgment to the nations," etc., Psalm 71: "God, your judgment," etc., John 5: "he has given all judgment," etc., to which he joins gentleness, "he will not cry out." Ecclesiastes 9: "the words of the wise are heard," etc.; he shows, second, the equality of the judge: "nor will he accept a person." Acts 10: "God is not a respecter of persons." To which he joins piety in coming to aid: "nor shall his voice be heard outside," Judea, the voice of his preaching, that he might first come to the aid of those to whom he was sent. "I was not sent," etc. Matthew 15, Psalm 94: "today if his voice," etc., and in overlooking, "the reed," namely the kingdom of the Jews, "the flax," the priesthood. Ezekiel 34: "that which was broken," etc.; he shows also, third, the truth of judgment, "in truth," etc., Psalm 95: "he shall judge the world," etc., to which he joins joyfulness: "he shall not be sad," in heart; "troubled," in face: he was always cheerful and joyful, preserving an equality of mind, even though as regards the sensitive part there was a propassion of sadness — not indeed of necessity, but of will. Whence Matthew 26: "my soul is sorrowful," etc., Ecclesiasticus 30: "joy of heart," etc. Third he shows the power of dominion: "until he sets" the last judgment, or his precept, through the apostles preaching; "the law," the Gospel. Genesis 49: "he shall be the expectation," etc., below 60: "for the islands wait for me," etc. Others expound this of Darius, king of the Persians, who was gentle, just, and quiet, whom the Lord chose to free the Jews. "Thus says the Lord God," etc. Here he foretells the mission: and first he shows the power of the sender as regards the creation of heavenly things, "creating the heavens"; as regards the disposition of earthly things, "establishing the earth"; as regards the animation of living things, "giving breath," of natural life, "spirit," gratuitously. Zechariah 12: "the Lord stretching out the heaven," etc. Second he foretells the mission, setting forth the exaltation of the one sent: "I the Lord have called you," my son from eternity, by predestining to the unity of the divine person, "in justice," that is, that I may be just, fulfilling the promises. Romans 1: "who was predestined," etc. "I have taken the hand," as regards operation: John 14: "the Father remaining in me," etc., "and I have kept," lest you be held by death. Psalm 15: "you will not give your holy one," etc., below 49: "I called him and led him," etc.; he also sets forth the enjoining of office: "I have given you as a covenant," as a mediator, as it were. Genesis 9: "I will set my bow," etc. "For a light," etc., as an illuminator, as it were. Above 9: "to those dwelling in the region," etc., John 1: "he was the true light," etc.; he also shows the usefulness of this office against unbelief, "that you might open," etc., John 9: "I have come for judgment," etc., against the servitude of sin. "That you might lead forth," etc., Zechariah 9: "but you, in the blood of the covenant," etc. Third, from the mission, he concludes to the singularity of the divine majesty: as regards power, "I the Lord," etc., Psalm 67: "make a way for him," etc., Exodus 6: "my name Adonai," etc., "glory," by which I am called Lord. Luke 2: "glory in the highest," etc., and as regards knowledge, "the things which were first," etc., below 49: "I told you from then," etc. This too they refer to Darius. "Sing to the Lord," etc. Here he invites to thanksgiving: and first he enjoins praise, and especially upon country-dwellers, either on account of the distance of their dwelling: "from the ends," above 24: "from the ends of the earth, praises," etc., or on account of being enclosed by the sea, "you who go down" — namely sailors — "the fullness of it," namely of the sea, that is, let all that by which it is filled praise God. Psalm 106: "those who go down to the sea," etc., or on account of dwelling in deserts. "Let it lift up," its voice in praise of God, "the desert," that is, its inhabitants, especially as regards the Ishmaelites, "in the houses," after the manner of other nations, who before were wandering through the desert. "Kedar," son of Ishmael. Above 35: "the deserts shall rejoice," etc.; or on account of dwelling in the mountains: "praise, you inhabitants of the rock," of that city in Palestine which is set among the rocks. Or of any mountain whatever. Below 55: "the mountains and the hills shall sing," etc., and he invites those of whom it seems less that they are given to praising God. Second he foretells the spreading abroad of divine praise: "they shall give glory to the Lord," in others, not only in themselves. Below, the last chapter: "I will send from among them those who are saved," etc. Mystically, all this concerns the conversion of the Gentiles to the faith. "The Lord like a strong man." Here he foretells, through the coming of Christ, the future fall: and concerning this he sets down four things. First, power: "the Lord like a strong man," for attacking the Jews through the Romans. Exodus 15: "the Lord like a man of war," etc., "zeal," of vengeance. Proverbs 6: "the zeal and fury of a man," etc. Second he sets down wrath, "he shall cry out," through the tribulations which he will send upon them; against that which was said above, "he will not cry out" — for at first, coming, he showed gentleness. But to those who despise him he shows indignation. Job 37: "he shall thunder with his voice," etc. Third he sets down justice: because it is just that, since he has long waited for the impenitent, he should swallow them all up together at once: "I have kept silent," always, etc., Job 3: "did I not dissemble," etc., "I was patient." Above 30: "therefore the Lord waits," etc., "like a woman in labor," I will bring forth the pain that was dissembled, as a woman brings forth the child conceived. Or: because, like a woman in travail, I will grieve over so grave a punishment. Fourth he sets down the punishment as regards men: "I will make the mountains desolate" — the greater ones; "the hills" — the middling; "the sprout" — the common people. Ezekiel 35: "mount Seir a desert," etc., and as regards the withdrawal of all doctrine or consolation, "I will make the rivers," etc., Psalm 106: "he turned rivers into a desert," etc. This too can be referred to the destruction of the enemies of the Jews through Darius. "And I will lead forth." Here he sets forth (the resurrection) of the good, as regards three things. First, as regards the restoration of act: "I will lead forth the blind," namely the Gentiles, "into the way," Christ, or the precept of the law; or also the Jews, according to another exposition. Proverbs 4: "I will lead you through the paths," etc.; second, as regards the illumination of the intellect: "I will turn darkness," etc., Luke 1: "to give light to those who are in darkness," etc.; third, as regards the direction of the affections. "The crooked things," namely hearts, above 40: "the crooked things shall become straight," etc. "These words I did to them," etc. Here he shows the perversity of the Jews: and first he shows them ungrateful for benefits; second, hard toward the precepts, "hear, you deaf," third, obstinate amid scourges, "who is there among you," etc. Concerning the first, two things. First he shows ingratitude, "these words," namely the aforesaid benefits. "They are turned back," from me, Jeremiah 5: "you have forsaken me," etc. Second he calls down upon them confusion, "let them be confounded," etc., Psalm 118: "let all be confounded," etc. "Hear, you deaf." Here he shows them hard, or disobedient, toward the precepts. And first he shows their hardness, calling them deaf, and blind together. (For their malice blinded them: Wisdom 2), although they have eyes, and ears, of the body — which he proves because those who see keep watch, and those having the ears of the heart open obey. "Sold," into the servant of sin, for the delight of temporal good, 3 Kings 21: "you have been sold to do," etc. "You who have open," etc., Jeremiah 5: "hear, O foolish people," etc., above 6: "blind the heart of this people," etc. Second he shows the folly of the hardened, by this: that in the precepts the Lord intended their benefit. Whence he sets forth the Lord's intention: "and the Lord willed him," the people; and that the people itself might magnify the law of God, by keeping it in their heart; and that the Lord might extol, that is, exalt, the people. 1 Thessalonians 4: "this is the will of God," etc.; and he also shows their contradiction, because they sinned in themselves: "but he himself, plundered," by demons through various sins, and therefore "laid waste," by enemies — above 18: "from a people torn apart," etc.; they also offered others an occasion of sinning, "a snare," that is, an occasion for sinning, "of the young," of the foolish. Hosea 5: "you have become a snare," etc., and because they hid their sins, "in houses of prison," that is, in the secret place of the heart. "With heart and heart," etc. Third he sets down the punishment: "they have become for a prey," etc. "Nor is there one to deliver," by the power of wars; "nor is there one to say," by the urgency of prayer. Ecclesiasticus, the last chapter: "they surrounded me on every side," etc.; or there the punishment begins, "in houses of prison," so that it be expounded according to the letter. "Who is there among you." Here he shows them incorrigible through scourges, because they do not even recognize the cause of the scourges: and concerning this he does three things. First he inquires after one who thinks rightly, hinting at their fewness. "The things to come," which I foretell concerning your punishments. Hosea, the last chapter: "who is wise," etc. Second he determines the truth as regards the author of the punishment: "who gave," etc., 1 Kings 2: "the Lord puts to death," etc.; as regards the fault: "he it is against whom," etc., Baruch 4. "They did not know his justices," etc.; and as regards the punishment, "and he poured out," etc., Psalm 68: "pour out your wrath upon them," etc. — "pouring out" signifies abundance. Third he excludes the recognition of the truth: "and it burned him," namely with material fire through the devastation of enemies; "he did not know," that he was punished by God for his sins. Psalm 81: "they did not know nor understand," etc. (Collationes, chapter 42.) "Cry" — of devout prayer, Hebrews 5: "with a strong cry," etc.; of attentive preaching, John 7: "on the last day of the feast," etc.; of strife and contention, above 5: "he waited that it should do," etc. Christ is given "for a covenant" of preserving salvation, Genesis 9: "my bow," etc., of fulfilling promise, II Corinthians 1: "as many as are the promises," etc., of divine love, John 3: "so God loved," etc., of the law that is to cease, Psalm: "holocausts for sin," etc.”

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“And I will bring the blind by a way that they knew not,.... The Targum interprets this of the people of Israel, thus, "I will lead the house of Israel, which are like to the blind, in a way which they knew not.'' But it is better to understand it of the Gentiles, who, before the light of the Gospel came among them, were blind as to the true knowledge of God, and especially as in Christ; and of Christ, and the way of peace, life, and salvation by him; and of themselves, and their miserable estate and condition; and of the Spirit of God, and his operations; and of the Scriptures, the Gospel, and the doctrines of it; and which is the case of all men in a state of nature: but the Lord, by his Spirit, opens the eyes of their understandings, and shows them those things they were blind in, and ignorant of, and brings them by a way they knew not before; which way is Christ, the only way to the Father; the way of peace, righteousness, and life; the way to heaven, and eternal happiness: this they knew not before, but thought they must make their own way to God, and their peace with him; must be justified by their own works, and work out their own salvation; but, in conversion, this way to Christ is made known and plain unto them; and in this way the Lord brings all his people to eternal glory: I will lead them in paths that they have not known; in the paths of duty and truth; in the paths of faith, righteousness, and holiness, and in the ordinances of the Gospel; which they were aliens and strangers to before: I will make darkness light before them; by going before them himself, as before the children of Israel in a pillar of fire by night; by giving his word to enlighten them; by granting his good Spirit, as a spirit of illumination to them; and by lifting up the light of his countenance on them: and crooked things straight; remove all obstructions, bear them up under all discouragements, and carry them through all difficulties: these things will I do unto them, and not forsake them; which may be depended upon, being promised by him that is able to perform, is true, and faithful, and changes not; and, when done, shall not be the last done for them; he will never leave them, nor forsake them, till he has brought them safe to glory.”
Source
1849
A.D.
1871
A.D.
1871
“blind--God's people, Israel, in captivity, needing a guide. In the ulterior sense the New Testament Church, which was about to be led and enlightened by the Son of God as its leader and shepherd in the wilderness of the Roman empire, until it should reach a city of habitation. "A way . . . they knew not," refers to the various means ployed by Providence for the establishment of the Church in the world, such as would never have occurred to the mind of mere man. "Blind," they are called, as not having heretofore seen God's ways in ordering His Church. make darkness light, &c.--implies that the glorious issue would only be known by the event itself [VITRINGA]. The same holds good of the individual believer (Isa 30:21; Psa 107:7; compare Hos 2:6, Hos 2:14; Eph 5:8; Heb 13:5).”
Source
1875
A.D.
Keil & Delitzsch Lutheran
1861–1875
“The great thing which is brought to pass by means of this catastrophe is the redemption of His people. "And I lead the blind by a way that they know not; by steps that they know not, I make them walk: I turn dark space before them into light, and rugged places into a plain. These are the things that I carry out, and do not leave." The "blind" are those who have been deprived of sight by their sin, and the consequent punishment. The unknown ways in which Jehovah leads them, are the ways of deliverance, which are known to Him alone, but which have now been made manifest in the fulness of time. The "dark space" (machshâk) is their existing state of hopeless misery; the "rugged places" (ma‛ăqasshı̄m) the hindrances that met them, and dangers that threatened them on all sides in the foreign land. The mercy of Jehovah adopts the blind, lights up the darkness, and clears every obstacle away. "These are the things" (haddebhârı̄m): this refers to the particulars already sketched out of the double manifestation of Jehovah in judgment and in mercy. The perfects of the attributive clause are perfects of certainty.”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.