The interpretation timeline
Isaiah 53:6 Douay-Rheims

All we like sheep have gone astray, every one hath turned aside into his own way: and the Lord hath laid on him the iniquity of us all.

A.D. 99 – 1875 9 witnesses

Patristic

before A.D. 750
99
A.D.
Clement of Rome Patristic
d. A.D. 99
“For Christ is of those who are humble-minded, and not of those who exalt themselves over His flock. Our Lord Jesus Christ, the Sceptre of the majesty of God, did not come in the pomp of pride or arrogance, although He might have done so, but in a lowly condition, as the Holy Spirit had declared regarding Him. For He says, "Lord, who has believed our report, and to whom is the arm of the Lord revealed? We have declared [our message] in His presence: He is, as it were, a child, and like a root in thirsty ground; He has no form nor glory, yea, we saw Him, and He had no form nor comeliness; but His form was without eminence, yea, deficient in comparison with the [ordinary] form of men. He is a man exposed to stripes and suffering, and acquainted with the endurance of grief: for His countenance was turned away; He was despised, and not esteemed. He bears our iniquities, and is in sorrow for our sakes; yet we supposed that [on His own account] He was exposed to labour, and stripes, and affliction. But He was wounded for our transgressions, and bruised for our iniquities. The chastisement of our peace was upon Him, and by His stripes we were healed. All we, like sheep, have gone astray; [every] man has wandered in his own way; and the Lord has delivered Him up for our sins, while He in the midst of His sufferings opens not His mouth. He was brought as a sheep to the slaughter, and as a lamb before her shearer is dumb, so He opens not His mouth. In His humiliation His judgment was taken away; who shall declare His generation? For His life is taken from the earth. For the transgressions of my people was He brought down to death. And I will give the wicked for His sepulchre, and the rich for His death, because He did no iniquity, neither was guile found in His mouth. And the Lord is pleased to purify him by stripes. If you make an offering for sin, your soul shall see a long-lived seed. And the Lord is pleased to relieve Him of the affliction of His soul, to show Him light, and to form Him with understanding, to justify the Just One who ministers well to many; and He Himself shall carry their sins. On this account He shall inherit many, and shall divide the spoil of the strong; because His soul was delivered to death, and He was reckoned among the transgressors, and He bare the sins of many, and for their sins was He delivered." [Isaiah 53:1-12] And again He says, "I am a worm, and no man; a reproach of men, and despised of the people. All that see me have derided me; they have spoken with their lips; they have wagged their head, [saying] He hoped in God, let Him deliver Him, let Him save Him, since He delights in Him." [Psalm 22:6-8] You see, beloved, what is the example which has been given us; for if the Lord thus humbled Himself, what shall we do who have through Him come under the yoke of His grace?”
Source
215
A.D.
c. A.D. 150–215
“Isaiah says [about Christ], "The Lord has laid on him the iniquity of us all," that is, to correct our iniquities and set them right. For that reason, he alone is able to forgive our sins, he who has been appointed by the Father of all as our educator, for he alone is able to separate obedience from disobedience.”

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
“We all went astray like sheep Now it is revealed that all the heathens (nations [mss.]) had erred. accepted his prayers He accepted his prayers and was appeased concerning the iniquity of all of us, that He did not destroy His world. accepted...prayers Heb. הִפְגִּיעַ, espriad in O.F., an expression of supplication.”
1167
A.D.
Ibn Ezra Jewish
1089–1167
“All we like sheep, etc. At last they will acknowledge the truth; that it was an error to think him smitten of God (ver. 4), comp. Surely our fathers have inherited lies, etc. (Jer. 16:14). הפגיע Hath laid. Lit. Hath caused to meet; comp. ויפגע and he alighted (Gen. 28:11). עון Lit. iniquity; here it means the punishment for the iniquity. Comp. עון punishment (1 Sam. 28:10; Gen. 15:16; Lam. 4:6). Some explain הפגיע he caused to pray; עון has, according to their opinion, the usual meaning iniquity; and the sense of the whole phrase is: God will accept the prayer of Israel, that peace shall be on earth. Comp. And seek the peace of the city, etc. (Jer. 29:7). But עון in this sense, joined with הפגיע בו, is rather an unusual construction.”
Source
1256
A.D.
Thomas Aquinas Catholic
1225–1274
“Who has believed? Here he begins to set down remedies against the obstacles spoken of: and first, against sin, he promises the passion of Christ; second, against dejection, he promises exaltation, chapter 54: Give praise, thou barren; third, against poverty, he promises the free enjoyment of things, (chapter 55), All you that thirst. On the first point, two things. First he shows the loftiness of the mystery, because it is not easily believed even by report. By report — of those things which we have heard from you concerning Christ. (Abdias): We have heard a report, etc.; Habacuc 3: Lord, I have heard your hearing, and I feared. Nor is it easily seen — and the arm, that is, the Son of God, the power of God. Job 40: If you have an arm like God. Second, he pursues the order of what came to pass: and first, setting forth a likeness as to his exaltation: and he shall ascend — being born from his mother's womb, rising again from death, ascending from the world into heaven, and into the faith of the nations — like a young shoot, which grows upward and multiplies broadly. Above, 11: There shall come forth a rod out of the root of Jesse, and a flower shall rise out of his root. And as to his humanity: and as a root out of thirsty ground — that is, out of ground without moisture, which by reason of its dryness appears unlovely; so too he himself was born of his mother without male moisture. Apocalypse, last chapter: I am the root of David. Second, he sets down the exposition of the likeness: there is not. And first as to his humiliation; second as to his exaltation, from anguish. On the first, two things. First he describes Christ's humility; second, the meekness of the humbled one, he was offered. On the first, three things. First he describes the office of humility; second, the contempt of the humbled one, and as it were hidden; third, the fruit of the humiliation, but he was wounded. On the first, two things. First his humility is shown as to the concealment of his majesty: there is not to him beauty — as to the abundance of interior goods — nor comeliness — as to the abundance of exterior goods: for beauty properly regards loveliness as to the proportion of the members, but comeliness regards the fittingness of color and of the other things surrounding it. He had, indeed, beauty, for he was beautiful in form beyond the sons of men (Psalm 44); but it lay hidden on account of the weakness he had assumed. He had comeliness, for strength and comeliness are his clothing, Proverbs, last chapter; but it lay hidden on account of the poverty he kept. Whence Canticles 2: Let your voice sound in my ears. And therefore we — who were then unbelieving and afterward converted, in whose person he speaks — saw him, bodily, and there was no — magnificent — appearance, according to what is said, that the beauty of Priam was worthy of empire. Second, his humility is shown as to the manifestation of weakness: and we desired him, awaiting him with desire as a great redeemer. Aggeus 2: Behold, the desired of all nations shall come. And in dignity, against which we saw him despised, inglorious, the most abject of men, on account of the most shameful kind of death. Wisdom 2: Let us condemn him to a most shameful death. Proverbs 30: I am the most foolish of men. Great also in prosperity; against which we find him a man of sorrows, as it were wretched, full of sorrows. Lamentations 1: O all you who pass by the way, attend and see if there is sorrow like my sorrow. Great also in power; against which we find him knowing infirmity, by experience. 2 Corinthians, last chapter: For though he was crucified through weakness, yet he lives by the power of God. And as it were hidden. Here he shows the contempt of the humbled one: and first as to the majesty concealed in the withdrawal of honor, as it were hidden — majesty lying concealed beneath the weakness of the flesh. Whence we esteemed him not — not paying him the honor due. Above, 45: Truly you are a hidden God. Second, as to the weakness displayed, setting down the sign of that weakness: truly — as a true man — infirmities: weaknesses, such as hunger and thirst, he bore, he sustained; sorrows, sensible ones, in the passion; and sadness — or, taking infirmities as sins — he took away from us, or, in our place, he sustained the punishments. 1 Peter 2: He bore our sins upon the wood. Setting down also the contempt: and we esteemed him as it were a leper, unclean and a sinner, and therefore struck by God — for his own sins, as to the punishments — and humbled, as to the disgraces. Job 22: For your very great malice, and your infinite iniquities. And 39: They abhor, etc. Note on that word: And to whom is the arm of the Lord revealed? — that Christ is the arm, first, for scourging the demons. Psalm 88: With the arm of your strength you have scattered your enemies. Second, for supporting the weak. Above, 40: In his arm he will lift up the lambs. Third, for defending the faithful. Wisdom 5: His right hand shall rule them. Likewise on that word, young shoot — that Christ is the rod, first, for striking. Numbers 24: A star shall rise out of Jacob, and a rod shall spring up from Israel; second, for sustaining. Psalm 22: Your rod and your staff, they have comforted me. Third, for directing. Psalm 44: The rod of your direction. Likewise on that word, a root out of the ground — that Christ is the root, first, on account of its being hidden. Ecclesiasticus 1: To whom has the root of wisdom been revealed? Second, on account of the ministering of nourishment. Jeremias 17: He shall be like a tree that sends out its roots toward moisture. Third, on account of the sustaining of the whole tree. Romans 11: You do not carry the root. But he was wounded. Here he sets down the fruit of the humiliation, or of the passion: and first he assigns the moving reason: but he, not as we thought, was wounded — with thorns, nails, the lance — for our iniquities, to be taken away. Bruised — with scourges and blows. Or, wounded, as to what is said, struck; bruised, as to what is said, humbled. Lamentations 4: The spirit of our mouth, Christ the Lord. Second, he shows the benefit that follows, in the reconciliation of peace: the chastisement of peace — that is, he himself, for us, sustained the chastisement of correction; through which peace we have access to God. Romans 5: For if, when we were enemies, we were reconciled to God through the death of his Son; and in the restoration of lost health, by his bruise, which he had from the rods. 1 Peter 2: By whose bruise you were healed. Psalm 102: Who is propitious to all your iniquities, who heals all your infirmities. Third, he shows the necessity impending on our part, because all were infirm: whence all need a physician, and no other could supply a sufficient remedy. Romans 3: For there is no distinction between the Jew and the Greek: for all have sinned, and need penance. All we like sheep — 1 Peter 2: You were once as sheep not having a shepherd. He was offered. Here he shows the meekness of the sufferer; and first he sets forth this meekness itself, and first as to his voluntary offering of himself: he was offered — to God the Father, for us, as a victim; Psalm 53: I will freely sacrifice to you. Second, as to his patient suffering: and he opened not his mouth — as one contradicting and contending: even before Herod he answered nothing, Luke 23. Lamentations 4: Out of the mouth of the Most High, etc. Second, he sets down a likeness: as a sheep to the slaughter — because he was killed without resistance — and as a lamb, suffering injury without contradiction. Jeremias 11: I am as a lamb that is carried to be a victim. Note on that word, the most abject — that Christ was the most abject, first on account of the bitterness of his sorrow. Lamentations 1: O all you who pass by the way, attend and see if there is sorrow like my sorrow. Second, on account of the shamefulness of his death. Wisdom 2: Let us condemn him to a most shameful death. Third, on account of the greatness of the crime laid upon him. Proverbs 30: I am the most foolish of men, and the wisdom of men is not with me. Likewise on that word, a man of sorrows — that Christ was full of sorrows, first on account of the necessity of the malady. Above, 1: From the sole of the foot even to the crown there is no soundness in it. Second, on account of the outpouring of graces. John 1: Of his fullness we have all received grace. Third, on account of our obligation. 2 Corinthians 5: For this Christ has died, etc. From anguish. Having set down the humility of the passion, here he begins to set forth the glory of the exaltation, which is the reward of the passion, as is said, Philippians 2: For which cause God has exalted him. And first as to the escaping of dangers; second as to the vengeance upon his enemies, and he shall give the wicked; third as to the justification of men, if he shall lay down; fourth as to the victory over rebels, therefore will I distribute. On the first, two things. First he sets down the reward: from anguish — of the passion; from judgment — the unjust judgment by which he was judged by others — he was taken up, in the resurrection. Proverbs 11: The just man is delivered out of anguish. Second, he sets down the merit, setting forth the dignity of the sufferer, so that from the condition of the person the merit of the passion might be weighed: his generation — the eternal one, by which he is from the Father without a mother, or the temporal one, by which he is from a mother without a father — who? As it were no one, by natural reason, although in some measure by divine inspiration. Ecclesiasticus 43: Who has seen him, and shall declare? Setting down also the passion inflicted upon him: for he was cut off — by death, at the hands of the Jews — out of the land of the living — out of this life. Jeremias 12: Come, let us put wood into his bread, and root him out of the land of the living. Setting down also, on the part of God the Father, the acceptance of the passion: for the wickedness I struck — I permitted him to be struck. 1 Peter 3: Christ once for our sins, etc. And he shall give the wicked. Here he sets down the second point, namely the vengeance upon those who persecuted him: and first he sets down the reward: and he shall give the wicked — the Jews, into the hands of the Romans — for burial — because they had him guarded in the sepulcher. Proverbs 21: For the just shall be given, etc. Second, he sets down the merit as to the innocence of his life: because he did no iniquity — as to the sin of deed; in his mouth — as to the sin of the mouth. 1 Peter 2: Who did no sin, neither was guile found in his mouth. And as to his obedience unto death: and the Lord — the Father — willed. And he himself was obedient to the Father even unto death. Philippians 2: Become obedient unto death. 1 Corinthians 1: That which is weak of God is stronger than men. If he shall lay down. Here he sets down the third point, namely that through him the justification of men was accomplished: and first he sets down the reward against the sorrow of death, if he shall lay down — of his own will. John 10: I lay down my life. He shall see a long-lived seed — unto the end of the world, sons being regenerated for him by the power of his death. John 12: Unless the grain of wheat falling into the ground be dead, itself remains alone; but if it be dead, it brings forth much fruit. And the will shall be directed — shall be fulfilled — in his hand — in his work. 1 Thessalonians 4: This is the will of God, your sanctification. And against the labor of teaching: because he labored — in preaching and going about — he shall see — the nations converted to him — and shall be satisfied — as one having what he intends. John 4: I have food to eat which you know not. Second, he sets down the merit as to the exercise of preaching: by knowledge — that is, by teaching. Romans 5: Justified freely by faith. John 6: Lord, to whom shall we go? You have the words of eternal life. And as to the torment of death: iniquities — that is, the punishments for iniquities. Above, 46: I have made, I will bear. Therefore will I distribute. Here he sets down the fourth point, namely the victory over enemies: and first he sets down the subjection of the enemies: therefore will I distribute — as it were, I will give him his portion — the many — who shall believe in him — and he shall divide the spoils of the strong — that is, of those held captive by the demons — to his disciples, setting different ones over different nations. Osee 13: He shall snatch away the treasure of every desirable vessel. Psalm 67: The king of powers, of the beloved, beloved, and of the beauty of the house, to divide the spoils. Second, he sets down the reason of the subjection: as to death, because he delivered — and as to the kind of death, and with the wicked. Luke 23: And there were crucified with him two malefactors. Psalm 87: I am reckoned with them that go down into the pit. Third, the salvation of those subjected. For he did not subject them to himself as a tyrant, to torment them, but to save them. And he himself bore the sin of many — efficiently, though of all sufficiently — took it away, and prayed for the transgressors. Luke 23: Father, forgive them, for they know not what they do.”

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“All we like sheep have gone astray,.... Here the prophet represents all the elect of God, whether Jews or Gentiles; whom he compares to "sheep", not for their good qualities, but for their foolishness and stupidity; and particularly for their being subject to go astray from the shepherd, and the fold, and from their good pastures, and who never return of themselves, until they are looked up, and brought back by the shepherd, or owner of them; so the people of God, in a state of nature, are like the silly sheep, they go astray from God, are alienated from the life of him, deviate from the rule of his word, err from the right way, and go into crooked paths, which lead to destruction; and never return of themselves, of their own will, and by their own power, until they are returned, by powerful and efficacious grace, unto the great Shepherd and Bishop of souls; see Pe1 2:25 where the apostle has a manifest respect to this passage: we have turned everyone to his own way; and that is an evil one, a dark and slippery one, a crooked one, the end of it is ruin; yet this is a way of a man's own choosing and approving, and in which he delights; and it may not only intend the way of wickedness in general, common to all men in a state of nature, but a particular way of sinning, peculiar to each; some are addicted to one sin, and some to another, and have their own way of committing the same sin; men turn their faces from God, and their backs upon him, and look to their own way, and set their faces towards it, and their hearts on it; and which seems right and pleasing to them, yet the end of it are the ways of death; and so bent are men on these ways, though so destructive, that nothing but omnipotent grace can turn them out of them, and to the Lord; and which is done in consequence of what follows: and the Lord hath laid on him the iniquity of us all; that is, God the Father, against whom we have sinned, from whom we have turned, and whose justice must be satisfied; he has laid on Christ, his own Son, the sins of all his elect ones; which are as it were collected together, and made one bundle and burden of, and therefore expressed in the singular number, "iniquity", and laid on Christ, and were bore by him, even all the sins of all God's elect; a heavy burden this! which none but the mighty God could bear; this was typified by laying of hands, and laying of sins upon the sacrifice, and putting the iniquities of Israel upon the head of the scapegoat, by whom they were bore, and carried away. The words may be rendered, "he made to meet upon him the iniquity of us all" (r); the elect of God, as they live in every part of the world, their sins are represented as coming from all quarters, east, west, north, and south; and as meeting in Christ, as they did, when he suffered as their representative on the cross: or "he made to rush, or fall upon him the iniquity of us all" (s); our sins, like a large and mighty army, beset him around, and fell upon him in a hostile manner, and were the cause of his death; by which means the law and justice of God had full satisfaction, and our recovery from ruin and destruction is procured, which otherwise must have been the consequence of turning to our own ways; so the ancient Jews understood this of the Messiah. R. Cahana (t) on these words, "binding his ass's colt to the choice vine", Gen 49:11 says, "as the ass bears burdens, and the garments of travellers, so the King Messiah will bear upon him the sins of the whole world; as it is said, "the Lord hath laid on him the iniquity of us all",'' Isa 53:6. (r) "fecit occarrere in eum iniquitatem omnium hostrum", Montanus; "occurrere fecit ei, vel irruere fecit in ilium", Vatablus. (s) "Incurrere fecit in eum", Cocceius, Vitringa, Forerius; "irruere fecit in ilium", Vatablus; sic Syr. "fecit ut incurreret iniquitas", Piscator. (t) Apud Galatin. de Cathol. Ver. I. 10. c. 6. p. 663, and Siphre in ib. l. 8. c. 20. p. 599.”
Source
1849
A.D.
1774–1849
“Astray. We belong to his fold, chap. xl. 11., John x. 11., and Luke xv. 4.— Laid. Septuagint, “abandoned him to our sins,” as to so many executioners; (Calmet) “and he, because he had been abused, opened,” &c. (Haydock)”
1871
A.D.
1871
“Penitent confession of believers and of Israel in the last days (Zac 12:10). sheep . . . astray-- (Psa 119:176; Pe1 2:25). The antithesis is, "In ourselves we were scattered; in Christ we are collected together; by nature we wander, driven headlong to destruction; in Christ we find the way to the gate of life" [CALVIN]. True, also, literally of Israel before its coming restoration (Eze 34:5-6; Zac 10:2, Zac 10:6; compare with Eze 34:23-24; Jer 23:4-5; also Mat 9:36). laid--"hath made to light on Him" [LOWTH]. Rather, "hath made to rush upon Him" [MAURER]. the iniquity--that is, its penalty; or rather, as in Co2 5:21; He was not merely a sin offering (which would destroy the antithesis to "righteousness"), but "sin for us"; sin itself vicariously; the representative of the aggregate sin of all mankind; not sins in the plural, for the "sin" of the world is one (Rom 5:16-17); thus we are made not merely righteous, but righteousness, even "the righteousness of God." The innocent was punished as if guilty, that the guilty might be rewarded as if innocent. This verse could be said of no mere martyr.”
Source
1875
A.D.
Keil & Delitzsch Lutheran
1861–1875
“Thus does the whole body of the restored Israel confess with penitence, that it has so long mistaken Him whom Jehovah, as is now distinctly affirmed, had made a curse for their good, when they had gone astray to their own ruin. "All we like sheep went astray; we had turned every one to his own way; and Jehovah caused the iniquity of us all to fall on Him." It is the state of exile, upon which the penitent Israel is here looking back; but exile as being, in the prophet's view, the final state of punishment before the final deliverance. Israel in its exile resembled a scattered flock without a shepherd; it had lost the way of Jehovah (Isa 63:17), and every one had turned to his own way, in utter selfishness and estrangement from God (Isa 56:11). But whereas Israel thus heaped up guilt upon guilt, the Servant of Jehovah was He upon whom Jehovah Himself caused the punishment of their guilt to fall, that He might make atonement for it through His own suffering. Many of the more modern expositors endeavour to set aside the paena vicaria here, by giving to הפגּיע a meaning which it never has. Thus Stier renders it, "Jehovah caused the iniquity of all to strike or break upon Him." Others, again, give a meaning to the statement which is directly at variance with the words themselves. Thus Hahn renders it: Jehovah took the guilt of the whole into His service, causing Him to die a violent death through their crime. Hofmann very properly rejects both explanations, and holds fast to the fact that בּ הפגּיע, regarded as a causative of בּ פּגע, signifies "to cause anything to strike or fall upon a person," which is the rendering adopted by Symmachus: κύριος καταντήσαι ἐποίησεν εἰς αὐτὸν τὴν ἀνομίαν πάντων ἡμῶν. "Just as the blood of a murdered man comes upon the murderer, when the bloody deed committed comes back upon him in the form of blood-guiltiness inflicting vengeance; so does sin come upon, overtake (Psa 40:13), or meet with the sinner. It went forth from him as his own act; it returns with destructive effect, as a fact by which he is condemned. But in this case God does not suffer those who have sinned to be overtaken by the sin they have committed; but it falls upon His servant, the righteous One." These are Hofmann's words. But if the sin turns back upon the sinner in the shape of punishment, why should the sin of all men, which the Servant of God has taken upon Himself as His own, overtake Him in the form of an evil, which, even it if be a punishment, is not punishment inflicted upon Him? For this is just the characteristic of Hofmann's doctrine of the atonement, that it altogether eliminates from the atoning work the reconciliation of the purposes of love with the demands of righteousness. Now it is indeed perfectly true, that the Servant of God cannot become the object of punishment, either as a servant of God or as an atoning Saviour; for as servant of God He is the beloved of God, and as atoning Saviour He undertakes a work which is well pleasing to God, and ordained in God's eternal counsel. So that the wrath which pours out upon Him is not meant for Him as the righteous One who voluntarily offers up Himself but indirectly it relates to Him, so far as He has vicariously identified Himself with sinners, who are deserving of wrath. How could He have made expiation for sin, if He had simply subjected Himself to its cosmical effects, and not directly subjected Himself to that wrath which is the invariable divine correlative of human sin? And what other reason could there be for God's not rescuing Him from this the bitterest cup of death, than the ethical impossibility of acknowledging the atonement as really made, without having left the representative of the guilty, who had presented Himself to Him as though guilty Himself, to taste of the punishment which they had deserved? It is true that vicarious expiation and paena vicaria are not coincident ideas. The punishment is but one element in the expiation, and it derives a peculiar character from the fact that one innocent person voluntarily submits to it in His own person. It does not stand in a thoroughly external relation of identity to that deserved by the many who are guilty; but the latter cannot be set aside without the atoning individual enduring an intensive equivalent to it, and that in such a manner, that this endurance is no less a self-cancelling of wrath on the part of God, than an absorption of wrath on the part of the Mediator; and in this central point of the atoning work, the voluntarily forgiving love of God and the voluntarily self-sacrificing love of the Mediator meet together, like hands stretched out grasp one another from the midst of a dark cloud. Hermann Schultz also maintains that the suffering, which was the consequence of sin and therefore punishment to the guilty, is borne by the Redeemer as suffering, without being punishment. But in this way the true mystery is wiped out of the heart of the atoning work; and this explanation is also at variance with the expression "the chastisement of our peace" in Isa 53:5, and the equally distinct statement in Isa 53:6, "He hath laid on Him the iniquity of us all." It was the sin of all Israel, as the palindromically repeated kullânū emphatically declares, which pressed upon Him with such force when His atoning work was about to be decided, but עון is used to denote not only the transgression itself, but also the guilt incurred thereby, and the punishment to which it gives rise. All this great multitude of sins, and mass of guilt, and weight of punishment, came upon the Servant of Jehovah according to the appointment of the God of salvation, who is gracious in holiness. The third turn ends here. It was our sins that He bore, and for our salvation that God caused Him to suffer on our account.”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.