The interpretation timeline
Isaiah 65:20 Douay-Rheims

There shall no more be an infant of days there, nor an old man that shall not fill up his days: for the child shall die a hundred years old, and the sinner being a hundred years old shall be accursed.

A.D. 430 – 1875 10 witnesses

Patristic

before A.D. 750
430
A.D.
Augustine of Hippo Patristic
A.D. 354–430
“It is usual for the prophets thus to mingle metaphorical and literal expressions. Yet, anyone with serious purpose and a little useful and salutary effort can discern the prophet's spiritual sense; it is only a lazy and worldly person or one who is ignorant or uneducated who will rest content with the literal and superficial sense and refuse to penetrate the deeper meaning.”
Source

Medieval

c. 750 – 1100
850
A.D.
Ishodad of Merv Medieval
d. A.D. 850
“"For the child shall die a hundred years old, and the sinner a hundred years old shall be accursed." Some authors understand these words as referring to the time after the return from exile. For a hundred years their prosperity lasted, and then the Macedonian kings rose against them. This is clearly explained in the book of the Maccabees.”
Source

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
“a youth Heb. עוּל יָמִים, a youth. Comp. (Lam. 2:11) “young children (עוֹלֵל).” [Hence,] עוּל יָמִים means young in years. who is one hundred years old shall die He shall be subject to punishments to be liable to death for a capital sin. So it is explained in Gen. Rabbah (26:2). shall be cursed for a sin requiring an anathema.”
Source
1167
A.D.
Ibn Ezra Jewish
1089–1167
“There shall be no more, etc. This verse shows, that those who will return to Zion will enjoy a long life. The old man will complete his days, that is, the days which the natural constitution of man permits him to live; he will live as long as the former generations from Adam to Noah lived; the same is the case with עולל=עול ימים infant of days. ימות וגו׳ כי הנער בן טאה שנה. For the young man shall die one hundred years old, etc. The sinner who dies a hundred years old, will be cursed; for if he lived less than that, his infancy will plead for him, his mental faculties not yet being fully developed; but being a hundred years old he is a young man, and being then a sinner, he is cursed. We learn from this verse that the world will at last be again as it was at the beginning.”
Source
1256
A.D.
Thomas Aquinas Catholic
1225–1274
“They have sought. Here the judge, namely God, gives the sentence concerning the distinguishing of the evil from the good, in the receiving of the promised salvation. And it is divided into two parts. In the first he pronounces the sentence of distinction; in the second he determines the manner of its execution, chapter 66: Thus says the Lord. Concerning the first, two things. First he promises a response, showing the fitting occasion for responding: They have sought; as if he were to say: until now you Jews were not seeking from me, but from idols. Since you now seek, I will respond. Mystically, concerning the conversion of the Gentiles. Romans 10: I was found by those who did not seek. And he sets down the promise: I said: Behold, I am to a nation: I will respond, namely, to the Jews, or I will turn to the nations that have been converted. Song of Songs 6: I am my beloved's, and my beloved is mine. Second, he pronounces the sentence of distinction: I have spread out my hands; and first he pronounces the distinguishing of the evil from the good on account of the sins of transgression; second, on account of the sins of omission: And you who have forsaken. The first is divided into two. In the first he threatens the wicked with punishments; in the second he promises the good their rewards: Thus says the Lord. Concerning the first, two things. First he charges them with the fault of transgression; second he threatens the punishment: These shall be smoke. He charges them with their fault on three grounds. First, from ingratitude for his benefits: I have spread out — by giving many benefits — all the day, that is, the whole time since I took them to myself. Mystically, on the cross. Jeremiah 16: Each one walks. Second, from the continuity of their sinning: a people before the face, because all things are naked and open to his eyes. Hebrews 4. Or because they set up an idol in the temple. Deuteronomy 32: They have provoked me with that which is not God. Third, from the diversity or gravity of their sins, with respect to four things. First, with respect to the worship of idols: who sacrifice — to idols — in gardens, because they worshipped idols in pleasurable places; upon bricks — upon altars built out of bricks, so that they could sustain the fire of the sacrifice. Above, chapter 1: They shall be confounded by their idols. Second, with respect to their pursuit of divinations: who dwell among the tombs, so that they might have answers from the dead; and in shrines — temples of idols, so called from diluendo, washing away, because there they thought all things were washed clean. Or because of the fountains that were there for washing the victims. And the priests sleep — upon the skins of the victims, for the sake of divination. Ezekiel 6: Your shrines shall be broken down. Third, with respect to the uncleanness of foods: who eat; and a profane broth, of swine. Below, the last chapter: those who ate swine's flesh, and the abomination, and the mouse, shall be consumed together. Fourth, with respect to their contempt of the just, who say — namely, to those not adoring idols; Wisdom 2: He is grievous to us; or who say — to God, Job 21: who say to God: Depart from us, we do not desire the knowledge of your ways. These shall be smoke. Here he threatens the punishment: and first the length of the punishment: smoke; that is, as smoke is consumed by fire; and they shall be kindled in my wrath. Deuteronomy 32: A fire is kindled in my fury, and shall burn even to the depths of hell. Second, the certainty of the punishment: Behold, it is written; because the sin is fixed firmly in memory, and the punishment in predetermination. I will not keep silence, dissembling. Jeremiah 17: The sin of Judah is written; above, chapter 42: I have kept silence, I have always held my peace. Third, the multitude of the punishments, because for all the sins of the fathers: but I will repay. Exodus 20: I am a jealous God, visiting the sins of the fathers upon the children. They have reproached — by adoring idols upon the high places; and for the sins also of their youth: and I will measure back — as if to say, I will measure the punishment to match the fault. Above, chapter 40: She has received double from the hand of the Lord. Thus says the Lord. Here he promises the good their rewards: and first, with respect to their preservation from evils: the grain, of the grape, a blessing; that is, it pleases God that it be kept in reserve as a blessing, for the sake of the servants: our fathers, that is, the whole race of the Jews. Above, chapter 17: It shall be like one gathering. Second, with respect to their advancement in goods: and first with respect to the multiplying of seed: And I will bring forth from Jacob. Above, chapter 1: Unless the Lord of hosts had left us a seed, we should have been like Sodom. Second, with respect to the restoring of their ancestral inheritance: And they shall inherit. Ezekiel 36: They shall possess you as an inheritance, and you shall be their inheritance. Third, with respect to the abundance of pastures: and there shall be plains, and the valley of Achor — named from him who was stoned there, Joshua 7. Hosea 2: I will give them the valley of Achor, to open hope. And you who have forsaken. Here he distinguishes the wicked from the consolation of the good, on account of their sins of omission: and first he threatens the wicked with punishments; second, the good with rewards, because to oblivion. Concerning the first, two things. First he threatens them because they have forsaken God, setting down the fault: and you, O Jews, to Fortune — the god of the Egyptians — a table: he touches upon the rite by which it was worshipped, because at the end of the year a table was prepared for it, laden with every kind of food. Deuteronomy 32: They forsook God who made them, and departed from God their savior. Setting down also the punishment: I will number; as if to say: so that none shall remain who is not oppressed. Jeremiah 44: They shall fall by the sword and by famine. Second, because they did not obey him calling them back, setting down the fault: because I called. Proverbs 1: I called, and you refused; and he threatens the punishment of this distinction, first in the satiety of the body: therefore thus says the Lord, Psalm 33: The rich have wanted and suffered hunger, but they that seek the Lord shall not be deprived of any good. Second, in the gladness of heart: Behold, my servants shall rejoice. Wisdom 5: Doing penance. Third, in the difference of name. And first he sets down what the name of the impious shall be: and you shall leave — as an oath, so that they might confirm their words thus: if it is not so, may it happen to me just as to them. Jeremiah 44: They shall die by the sword and by famine; and they shall be for an oath, and for a wonder, and for a curse, and for a reproach. And then he sets down what the name of the good shall be: and his servants — in which name, namely, the name is Jesus — Amen, that is, faithfully. Above, chapter 62: You shall be called by a new name, which the mouth of the Lord has named. Because to oblivion. Here he promises the seen rewards. And first, in general, with respect to the removal of evils: because to oblivion — not from a defect of knowledge, but from the succession of goods. Above, chapter 54: You shall forget the confusion of your youth. And with respect to the restoring of goods: for behold, I create new heavens — new helps from heaven; a new earth — new benefits from the earth. Or with reference to the day of judgment, when the world shall be renewed unto the glory of the saints. Apocalypse 21: The former things have passed away. Second, in particular: for behold, I create Jerusalem. And first, with respect to the gladness of hearts: Jerusalem — the earthly one; but rather heavenly exultation, emphatically, so that it might be wholly absorbed in joy. Above, chapter 35: They shall obtain joy and gladness, and sorrow and mourning shall flee from them. Second, with respect to the length of life: there shall no longer be one who does not fulfill — dying before his time; but the child shall die at a hundred years old, that is, when he has come to such an age; and if there be a sinner, although he has lived so long, he shall be subject to a curse. Genesis 25: Abraham died in a good old age. Mystically, in the heavenly Jerusalem all shall fulfill their days, because no one shall die. The child of a hundred years, that is, he who has lived childishly even up to the age of old age, shall die, with an eternal death. Wisdom 4: For venerable old age is not that of long time, nor counted by the number of years. Third, with respect to the prosperity of goods: both with respect to the security of possessions, and they shall build. Psalm: And they built houses; Amos, the last chapter: They shall plant vineyards. And he assigns the reason: for according to the days, that is, because they shall live long, just as the wood of a tree lasts long. They shall grow old; that is, they shall remain for their use even unto old age. Psalm 1: He shall be like a tree which is planted near the running waters. Above, chapter 49: They have labored in vain. And also with respect to the peace of their children: neither shall they beget in trouble, as those begetting children into the servitude of enemies. Ecclesiasticus 44: Good things continue with their seed. Fourth, with respect to the hearing of prayers: and it shall be, before they cry — with the mouth. Above, chapter 30: At the voice of your cry, as soon as he shall hear, he will answer you. Fifth, with respect to the tranquility of peace: the wolf and the lamb; because those who were formerly tyrants and evildoers shall dwell peaceably with others; above, chapter 11, the same.”

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“There shall be no more thence an infant of days,.... That is, there shall no more be carried out from thence, from Jerusalem, or any other place where the church of God is, to the grave, in order to be interred, an infant that has lived but a few days, a very common thing now; but, in the latter day, such instances will be rare, or rather there will be none at all; every child born will live to the age of man, and not be cut off by any premature death, either by any natural disease, or by famine, or sword, or any other calamity, which will now have no place: nor an old man that hath not filled his days; who, though he may in some sense, or in comparison of others, be said to be old, yet has not arrived to the full term of man's life, threescore years and ten, or more; for it seems, by what follows, as if the term of human life will be lengthened in the latter day, and reach in common to a hundred years; so that as long life is always reckoned a temporal happiness, among the rest that shall be enjoyed, this will be one in the latter day; and which is to be understood not of the Millennium state, in which there will be no death, Rev 21:4, which yet will be in this, as the following words show; but of the state preceding that, even the spiritual reign of Christ: for the child shall die an hundred years old; not that that shall be reckoned a child that shall die at a hundred years of age (h), the life of man being now, in these days of the Messiah, as long as they were before the flood, as the Jewish interpreters imagine; but the child that is now born, or he that is now a child, shall live to the age of a hundred years, and not die before: but lest this outward happiness should be trusted to, and a man should imagine that therefore he is in a happy state for eternity, being blessed with such a long life, it follows, "but" or though the sinner, being an hundred years old; shall be accursed; for though this shall be common in this state to good men and bad men, to live a hundred years, yet their death will not be alike; the good man will be blessed, and enter into a happy state of joy and peace; but the wicked man, though he lives as long as the other in this world, shall be accursed at death, and to all eternity; see Ecc 8:12. (h) Vid. Gloss. in T. Bab. Sanhedrin, fol. 91. 2.”
Source
1849
A.D.
1774–1849
“Fill up. To die soon was deemed a misfortune, Psalm liv. 24., and Exodus xx. 12. Virtue is the measure of the Christian’s life, and God will reward those who labour even late, Matthew xx. 13. — Accursed. This age will not be spared. Both just and wicked shall be immortal in eternity. (Theodoret)”
1863
A.D.
1796–1863
“Lit. " Upon the heart" M The Church, especially Jn her triumphant state. u No one shall be prematurely taken out of life. A man dying at the age of a hundred years shall be deemed a child in regard la the general longevity, and his death shall be considered a punishment which his sins provoked. This seems to refer to a state of great longevity ; but it may be understood of the Church, in which the regenerated Infant has the privileges of mature virtue, and the aged man may pos- sess the innocence of childhood. Age, however, does not shelter the sinner. St Jerome explains it of the resurrection: " At that time, when all shall be of the same age, and the saint and the sinner shall be perfected by a like resurrection, they shall not differ one from the other in time, but the one shall receive rewards, the other shall be dragged to punishment The sinner shall be accursed, inasmuch as he shall suffer eternal punishment his body remaining undissolved."”
Source
1871
A.D.
1871
“The longevity of men in the first age of the world shall be enjoyed again. thence--from that time forward. infant of days--that is, an infant who shall only complete a few days; short-lived. filled . . . days--None shall die without attaining a full old age. child . . . die . . . hundred years--that is "he that dieth an hundred years old shall die a mere child" [LOWTH]. sinner . . . hundred . . . be accursed--"The sinner that dieth at an hundred years shall be deemed accursed," that is, his death at so early an age, which in those days the hundredth year will be regarded, just as if it were mere childhood, shall be deemed the effect of God's special visitation in wrath [ROSENMULLER]. This passage proves that the better age to come on earth, though much superior to the present will not be a perfect state; sin and death shall have place in it (compare Rev 20:7-8), but much less frequently than now.”
Source
1875
A.D.
Keil & Delitzsch Lutheran
1861–1875
“There will be a different measure then, and a much greater one, for measuring the period of life and grace. "And there shall no more come thence a suckling of a few days, and an old man who has not lived out all his days; for the youth in it will die as one a hundred years old, and the sinner be smitten with the curse as one a hundred years old." Our editions of the text commence Isa 65:20 with לא־יהיה, but according to the Masora (see Mas. finalis, p. 23, col. 7), which reckons five ולא־יהיה at the commencement of verses, and includes our v. among them, it must read ולא־יהיה, as it is also rendered by the lxx and Targum. The meaning and connection are not affected by this various reading. Henceforth there will not spring from Jerusalem (or, what hâyâh really means, "come into existence;" "thence," misshâm, not "from that time," but locally, as in Hos 2:17 and elsewhere, cf., Isa 58:12) a suckling (see p. 90) of days, i.e., one who has only reached the age of a few days (yâmı̄m as in Gen 24:55, etc.), nor an old man who has not filled his days, i.e., has not attained to what is regarded as a rule as the full measure of human life. He who dies as a youth, or is regarded as having died young, will not die before the hundredth year of his life; and the sinner (והחוטא with seghol, as in Ecc 8:12; Ecc 9:18; Ges. 75, Anm. 21) upon whom the curse of God falls, and who is overwhelmed by the punishment, will not be swept away before the hundredth year of his life. We cannot maintain with Hofmann (Schriftbeweis, ii. 2, 567), that it is only in appearance that less is here affirmed than in Isa 25:8. The reference there is to the ultimate destruction of the power of death; here it is merely to the limitation of its power.”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.