The interpretation timeline
Isaiah 65:5 Douay-Rheims

That say: Depart from me, come not near me, because thou art unclean: these shall be smoke in my anger, a fire burning all the day.

A.D. 430 – 1871 7 witnesses

Patristic

before A.D. 750
430
A.D.
Augustine of Hippo Patristic
A.D. 354–430
“So insofar as they say, "Do not touch me, because I am pure," they are like this Pharisee who had invited the Lord and who thought [the Lord] did not know the woman, just because he had not stopped her touching his feet. But in another respect the Pharisee is better, in that while he thought Christ was only a man, he did not believe that sins could be forgiven by a man. So the Jews appear to have a better understanding than the heretics. What did the Jews say? "Who is this who even forgives sins?" Does a mere man have the audacity to claim this for himself?" What … does the heretic say? "I forgive, I cleanse, I sanctify."”
Source

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
“Those who say to the righteous, קְרַב אֵלֶיךָ, “Keep to yourself and do not come near me.” for I am holier than you Heb. כִּי קְדַשְׁתִּיךָ. For I am holier and purer than you. In this manner Jonathan renders. these abominations that they committed are as smoke, wrath in My nostrils.”
1167
A.D.
Ibn Ezra Jewish
1089–1167
“Which say. They, the unclean, say to the others, that have never eaten swine’s meat, etc. גשה אליך=קרב אליך Stand by thyself. Lit. Go nearer to thyself. קדשתיך I am holier than thou. It is an intransitive verb; as to the suffix, קרשתיך I am holier than thou. comp. יצאוני have gone out of me (Jer. x 20); similarly קדשתיך has the same meaning as קדשתי ממך I am holy, more than thou. אלה עשן באפי These put smoke in my nose.”
Source
1256
A.D.
Thomas Aquinas Catholic
1225–1274
“They have sought. Here the judge, namely God, gives the sentence concerning the distinguishing of the evil from the good, in the receiving of the promised salvation. And it is divided into two parts. In the first he pronounces the sentence of distinction; in the second he determines the manner of its execution, chapter 66: Thus says the Lord. Concerning the first, two things. First he promises a response, showing the fitting occasion for responding: They have sought; as if he were to say: until now you Jews were not seeking from me, but from idols. Since you now seek, I will respond. Mystically, concerning the conversion of the Gentiles. Romans 10: I was found by those who did not seek. And he sets down the promise: I said: Behold, I am to a nation: I will respond, namely, to the Jews, or I will turn to the nations that have been converted. Song of Songs 6: I am my beloved's, and my beloved is mine. Second, he pronounces the sentence of distinction: I have spread out my hands; and first he pronounces the distinguishing of the evil from the good on account of the sins of transgression; second, on account of the sins of omission: And you who have forsaken. The first is divided into two. In the first he threatens the wicked with punishments; in the second he promises the good their rewards: Thus says the Lord. Concerning the first, two things. First he charges them with the fault of transgression; second he threatens the punishment: These shall be smoke. He charges them with their fault on three grounds. First, from ingratitude for his benefits: I have spread out — by giving many benefits — all the day, that is, the whole time since I took them to myself. Mystically, on the cross. Jeremiah 16: Each one walks. Second, from the continuity of their sinning: a people before the face, because all things are naked and open to his eyes. Hebrews 4. Or because they set up an idol in the temple. Deuteronomy 32: They have provoked me with that which is not God. Third, from the diversity or gravity of their sins, with respect to four things. First, with respect to the worship of idols: who sacrifice — to idols — in gardens, because they worshipped idols in pleasurable places; upon bricks — upon altars built out of bricks, so that they could sustain the fire of the sacrifice. Above, chapter 1: They shall be confounded by their idols. Second, with respect to their pursuit of divinations: who dwell among the tombs, so that they might have answers from the dead; and in shrines — temples of idols, so called from diluendo, washing away, because there they thought all things were washed clean. Or because of the fountains that were there for washing the victims. And the priests sleep — upon the skins of the victims, for the sake of divination. Ezekiel 6: Your shrines shall be broken down. Third, with respect to the uncleanness of foods: who eat; and a profane broth, of swine. Below, the last chapter: those who ate swine's flesh, and the abomination, and the mouse, shall be consumed together. Fourth, with respect to their contempt of the just, who say — namely, to those not adoring idols; Wisdom 2: He is grievous to us; or who say — to God, Job 21: who say to God: Depart from us, we do not desire the knowledge of your ways. These shall be smoke. Here he threatens the punishment: and first the length of the punishment: smoke; that is, as smoke is consumed by fire; and they shall be kindled in my wrath. Deuteronomy 32: A fire is kindled in my fury, and shall burn even to the depths of hell. Second, the certainty of the punishment: Behold, it is written; because the sin is fixed firmly in memory, and the punishment in predetermination. I will not keep silence, dissembling. Jeremiah 17: The sin of Judah is written; above, chapter 42: I have kept silence, I have always held my peace. Third, the multitude of the punishments, because for all the sins of the fathers: but I will repay. Exodus 20: I am a jealous God, visiting the sins of the fathers upon the children. They have reproached — by adoring idols upon the high places; and for the sins also of their youth: and I will measure back — as if to say, I will measure the punishment to match the fault. Above, chapter 40: She has received double from the hand of the Lord. Thus says the Lord. Here he promises the good their rewards: and first, with respect to their preservation from evils: the grain, of the grape, a blessing; that is, it pleases God that it be kept in reserve as a blessing, for the sake of the servants: our fathers, that is, the whole race of the Jews. Above, chapter 17: It shall be like one gathering. Second, with respect to their advancement in goods: and first with respect to the multiplying of seed: And I will bring forth from Jacob. Above, chapter 1: Unless the Lord of hosts had left us a seed, we should have been like Sodom. Second, with respect to the restoring of their ancestral inheritance: And they shall inherit. Ezekiel 36: They shall possess you as an inheritance, and you shall be their inheritance. Third, with respect to the abundance of pastures: and there shall be plains, and the valley of Achor — named from him who was stoned there, Joshua 7. Hosea 2: I will give them the valley of Achor, to open hope. And you who have forsaken. Here he distinguishes the wicked from the consolation of the good, on account of their sins of omission: and first he threatens the wicked with punishments; second, the good with rewards, because to oblivion. Concerning the first, two things. First he threatens them because they have forsaken God, setting down the fault: and you, O Jews, to Fortune — the god of the Egyptians — a table: he touches upon the rite by which it was worshipped, because at the end of the year a table was prepared for it, laden with every kind of food. Deuteronomy 32: They forsook God who made them, and departed from God their savior. Setting down also the punishment: I will number; as if to say: so that none shall remain who is not oppressed. Jeremiah 44: They shall fall by the sword and by famine. Second, because they did not obey him calling them back, setting down the fault: because I called. Proverbs 1: I called, and you refused; and he threatens the punishment of this distinction, first in the satiety of the body: therefore thus says the Lord, Psalm 33: The rich have wanted and suffered hunger, but they that seek the Lord shall not be deprived of any good. Second, in the gladness of heart: Behold, my servants shall rejoice. Wisdom 5: Doing penance. Third, in the difference of name. And first he sets down what the name of the impious shall be: and you shall leave — as an oath, so that they might confirm their words thus: if it is not so, may it happen to me just as to them. Jeremiah 44: They shall die by the sword and by famine; and they shall be for an oath, and for a wonder, and for a curse, and for a reproach. And then he sets down what the name of the good shall be: and his servants — in which name, namely, the name is Jesus — Amen, that is, faithfully. Above, chapter 62: You shall be called by a new name, which the mouth of the Lord has named. Because to oblivion. Here he promises the seen rewards. And first, in general, with respect to the removal of evils: because to oblivion — not from a defect of knowledge, but from the succession of goods. Above, chapter 54: You shall forget the confusion of your youth. And with respect to the restoring of goods: for behold, I create new heavens — new helps from heaven; a new earth — new benefits from the earth. Or with reference to the day of judgment, when the world shall be renewed unto the glory of the saints. Apocalypse 21: The former things have passed away. Second, in particular: for behold, I create Jerusalem. And first, with respect to the gladness of hearts: Jerusalem — the earthly one; but rather heavenly exultation, emphatically, so that it might be wholly absorbed in joy. Above, chapter 35: They shall obtain joy and gladness, and sorrow and mourning shall flee from them. Second, with respect to the length of life: there shall no longer be one who does not fulfill — dying before his time; but the child shall die at a hundred years old, that is, when he has come to such an age; and if there be a sinner, although he has lived so long, he shall be subject to a curse. Genesis 25: Abraham died in a good old age. Mystically, in the heavenly Jerusalem all shall fulfill their days, because no one shall die. The child of a hundred years, that is, he who has lived childishly even up to the age of old age, shall die, with an eternal death. Wisdom 4: For venerable old age is not that of long time, nor counted by the number of years. Third, with respect to the prosperity of goods: both with respect to the security of possessions, and they shall build. Psalm: And they built houses; Amos, the last chapter: They shall plant vineyards. And he assigns the reason: for according to the days, that is, because they shall live long, just as the wood of a tree lasts long. They shall grow old; that is, they shall remain for their use even unto old age. Psalm 1: He shall be like a tree which is planted near the running waters. Above, chapter 49: They have labored in vain. And also with respect to the peace of their children: neither shall they beget in trouble, as those begetting children into the servitude of enemies. Ecclesiasticus 44: Good things continue with their seed. Fourth, with respect to the hearing of prayers: and it shall be, before they cry — with the mouth. Above, chapter 30: At the voice of your cry, as soon as he shall hear, he will answer you. Fifth, with respect to the tranquility of peace: the wolf and the lamb; because those who were formerly tyrants and evildoers shall dwell peaceably with others; above, chapter 11, the same.”

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“Which say, stand by thyself, &c. According to Aben Ezra, Jarchi, and Kimchi, these are the unclean persons that did the above things; who say to the righteous, "draw near to thyself" (p); so the words are, go to thine own place, or to thine own company: and come not near to me; keep off at a distance, as unworthy of such company: for I am holier than thou; but this is the language of a self-righteous man, of a Pharisee that strictly observed the rituals of the law; and fitly describes such who lived in the times of Christ; and exactly agrees with the characters of such, who not only would have no dealings with the Samaritans, but washed themselves when they came from market, or any public place, lest they should be defiled with the common people of their own nation; and, even with religious persons, would not stand near them while praying; but despised them, if they had not arrived to that pitch of outward sanctity they had; see Joh 4:9, Luk 18:9. The phrase may be rendered, "do not touch me" (q); and the Pharisees would not suffer themselves to be touched by the common people, nor would they touch them. Maimonides (r) says, "if the Pharisees touched but the garments of the common people, they were defiled all one as if they had touched a profluvious person, and were obliged to dip themselves all over;'' so that, when they walked in the streets, they used to walk on the sides of the way, that they might not be defiled by touching them (s). So Epiphanius (t) relates of the Samaritan Jews, that when they touch one of another nation, they dip themselves with their clothes in water; for they reckon it a defilement to touch anyone, or to touch any man of another religion; and of the Dositheans, who were another sect of the Samaritans the same writer observes (u), that they studiously avoid touching any, for they abhor every man. A certain Arabic geographer of note (w) makes mention of an island, called the island of the Samaritans, inhabited by some Samaritan Jews, as appears by their saying to any that apply to them, do not touch; and by this it is known that they are of the Jews who are called Samaritans; and this same arrogant superstition, as Scaliger observes (x), continues in that people to this day, as those relate who have conversed with them: these are a smoke in my nose, a fire that burneth all the day: very offensive to the divine Being, as smoke is to the eyes and nostrils; very abominable to him; and whose proud and vain conduct raised indignation in him, and kindled the fire of his anger, which was continually exercised on them; see Luk 16:15. The Targum is, "their vengeance is in hell, where the fire burns all the day.'' (p) "accede ad te", Vatablus, Montanus, Tigurine version, Cocceius; "appropinqua ad te", Piscator. (q) "ne contigas me"; so some in Vatablus; "ne attingite me", Junius & Tremellius, Piscator; "ne tangae rue": Cocceius. (r) In Misn. Chagiga, c. 2. sect. 7. (s) lb. Hilcot Abot Tumaot, c. 13. sect. 8. (t) Contra Haeres. haeres. 9. (u) Contra Haeres, haeres 13. (w) Apud Scaliger de Emendat, Temp. l. 7. (x) Ibid.”
Source
1849
A.D.
1774–1849
“Unclean. Thus acted the hypocritical Pharisees. — Smoke. A just punishment of those who had sought the smoke of human applause.”
1871
A.D.
1871
“(Mat 9:11; Luk 5:30; Luk 18:11; Jde 1:19). Applicable to the hypocritical self-justifiers of our Lord's time. smoke--alluding to the smoke of their self-righteous sacrifices; the fire of God's wrath was kindled at the sight, and exhibited itself in the smoke that breathed forth from His nostrils; in Hebrew the nose is the seat of anger; and the nostrils distended in wrath, as it were, breathe forth smoke [ROSENMULLER] (Psa 18:8).”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.