The interpretation timeline
Luke 2:48 Douay-Rheims

And seeing him, they wondered. And his mother said to him: Son, why hast thou done so to us? behold thy father and I have sought thee sorrowing.

A.D. 253 – 1832 7 witnesses 8 excerpts

Patristic

before A.D. 750
253
A.D.
Origen Patristic
c. A.D. 184–253
“But we must not wonder that they are called His parents, seeing the one from her childbirth, the other from his knowledge of it, deserved the names of father and mother.”
397
A.D.
Ambrose of Milan Patristic
A.D. 339–397
“There are two generations in Christ, one from His Father, the other from His mother; the Father’s more divine, the mother’s that which has come down for our use and advantage.”
735
A.D.
Bede the Venerable Patristic
c. A.D. 672–735
“For from His tongue there went forth divine wisdom, while His age exhibited man’s helplessness, and hence the Jews, amid the high things they hear and the lowly things they see, are perplexed with doubts and astonishment. But we can in no wise wonder, knowing the words of the Prophet, that thus unto us a Child is born, that He abideth the mighty God. (Is. 9:6.)”
Source

Reformation

c. 1500 – 1650
1637
A.D.
1567–1637
“And when they saiv him , they were amazed. His parents, who were seeking Him, wondered and rejoiced at finding him alone disputing with the doctors, manifesting such wisdom, while the doctors, and all the rest who were present, wondered at Him. And His mother said unto Him , Son, why hast thou thus dealt with us t behold , Thy father and / have sought thee sorrowing — the Arabic adds, “ with labour.” Such are the words of His mother, not as finding fault with Christ, but in wonder and in sorrow, and sorrowfully unfolding her grief. The reverence felt by this mother for her Child — the God-Man — assures us of this ; so it is most likely that she said this to Him, not publicly in the assemblage of doctors, but privately, calling Him aside, or when the assembly had dispersed. So Jansenius, Maldonatus, and others. Thy father and I. S. Augustine (Serm. 63 De JDwersis9 xi.) remarks upon the humility of the Virgin, who, knowing that she Digitized by Google THE HUMILITY OF MARY. 133 was in every sense (in solidum) the Mother of Christ, and, therefore, of God, and that Joseph had no part in begetting Him, yet modestly puts herself after Joseph as her husband. “ She expresses herself always,” says an anonymous writer in the “ Catena Graeca,” like a mother, with trustfulness, humility, and affection.” Tropologically, let the soul that has separated itself from Jesus by mortal sin, or from its wonted communion with Him by venial negligence, seek Him again (1) with the sorrow and tears of a penitent heart, for, as S. Gregory Nazianzen says {Orat. 3), “ The tears of righteous men ” (and of sinful too, if they repent) “ are the flood that covers sin, and the expiation of the world, as was Noah’s flood; (2) with earnestness and solicitude, as the Blessed Virgin did, and that in the Temple, by passing some time in prayer and in spiritual reading and meditation ; (3) among the doctors, among learned and good men, who shall instruct the soul as well in knowledge as in piety”
Source

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“And he said unto them, how is it that ye sought me?.... That is, with so much uneasiness and distress of mind, not trusting in the power and providence of God, to take care of him; and in other places, besides the temple, where they had been inquiring for him: wist ye not that I must be about my Father's business? or "in my Father's house", as the Syriac and Persic versions render it; where, as soon as you missed me, you might, at once, have concluded I was, and not have put yourselves to so much trouble and pains in seeking for me. Christ seems to tax them with ignorance, or, at least, forgetfulness of his having a Father in heaven, whose business he came to do on earth; and which they should have thought in their own minds he was now about, and so have made themselves easy. The business that Christ came about was to preach the Gospel, and which he afterwards performed with great clearness and fulness, with much power, majesty, and authority, with great constancy and diligence, with much concern for the souls of men, arid with great awfulness; and in which he took great delight, though he went through many dangers and risks of life; as also to work miracles in proof of his deity and Messiahship, and for the good of the bodies of men, and in which he was very assiduous, going about every where doing good this way: but the main, and principal part of his business was, to work out salvation for his people, by fulfilling the law, making reconciliation and atonement for their sins, and obtaining eternal redemption: this was a business which neither angels nor men could do; was very toilsome and laborious, and yet he delighted in it; nor did he desist from it until it was accomplished: and this is called his Father's business, because he contrived and assigned it to him; he called him to it, and sent him to perform; he enjoined it to him as man and mediator, and the glory of his perfections was concerned in it, and secured by it: and it was a business that Christ must be about, be concerned in, and perform, because he engaged to do it from all eternity; and because it was the will of his Father, which must be done, and was necessary in order to show himself dutiful and obedient; and because it was foretold in prophecy again and again and promised that it should be done; and because it could not be done by another. Now our Lord's conversing with the doctors, and which was a branch of his prophetic office, and was, no doubt, with a view to the good of the souls of men, and nothing less than miraculous, was a show, a prelude of, and a sort of an entrance upon the business he came about.”
Source
1832
A.D.
Adam Clarke Methodist
1762–1832
“Why hast thou thus dealt with us? - It certainly was not his fault, but theirs. Men are very apt to lay on others the blame of their own misconduct.”

Undated

date unknown
date
unknown
“(ubi sup.) But the ever-wonderful mother of God, moved by a mother’s feelings, as it were with weeping makes her mournful enquiry, in every thing like a mother, with confidence, humility, and affection. As it follows, And his mother said unto him, Son, what hast thou done?”
“(Geometer.) This is the first demonstration of the wisdom and power of the Child Jesus. For as to what are called thea acts of His childhood, we can not but suppose them to be the work not only of a childish but even of a devilish mind and perverse will, attempting to revile those things which are contained in the Gospel and the sacred prophecies. But should one desire to receive only such things as are generally believed, and are not contrary to our other declarations, but accord also with the words of prophecy, let it suffice that Jesus was distinguished in form above the sons of men; obedient to His mother, gentle in disposition; in appearance full of grace and dignity; eloquent in words, kind and thoughtful of the wants of others, known among all for a power and energy, as of one who was filled with all wisdom; and as in other things, so also in all human conversation, though above man, Himself the rule and measure. But that which most distinguished Him was His meekness, and that a razor had never come upon His head, nor any human hand except His mother’s. But from these words we may derive a lesson; for when the Lord reproves Mary seeking Him among His relations, He most aptly points to the giving up of all fleshly ties, shewing that it is not for him to attain the goal of perfection who is still encompassed by and walks among the things of the body, and that men fall from perfection through love of their relations.”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.