The interpretation timeline
Isaiah 22:4 Douay-Rheims

Therefore have I said: Depart from me, I will weep bitterly: labour not to comfort me, for the devastation of the daughter of my people.

A.D. 379 – 1875 9 witnesses 10 excerpts

Patristic

before A.D. 750
379
A.D.
Basil of Caesarea Patristic
c. A.D. 330–379
“Remember the compassion of God, how he heals with olive oil and wine. Do not despair of salvation. Recall the memory of what has been written, how he that falls rises again, and he that is turned away turns again, he that has been smitten is healed, he that is caught by wild beasts escapes, and he that confesses is not rejected. The Lord does not wish the death of the sinner, but that he return and live. Be not contemptuous as one who has fallen into the depths of sins.There is still time for patience, time for forbearance, time for healing, time for amendment. Have you slipped? Rise up. Have you sinned? Cease. Do not stand in the way of sinners, but turn aside; for then you will be saved when turning back you bewail your sins. In fact, from labors there is health; for sweat, salvation. So take heed, lest, in wishing to keep your contracts with others, you transgress your covenants with God that you confessed before many witnesses. Do not, therefore, because of certain human considerations, hesitate to come to me. For, receiving my dead, I shall lament; I shall care for him, "I shall weep bitterly for the devastation of the daughter of my people." All welcome you, all will aid you in your sufferings. Do not lose heart; be mindful of the days of old. There is salvation; there is amendment. Have courage; do not despair. There is no law that passes sentence of death without pity, but grace, exceeding the chastisement, awaits the amendment. Not yet have the doors been closed; the Bridegroom listens; sin is not the master. Again take up the struggle; do not draw back, but pity yourself and all of us in Jesus Christ, our Lord, to whom be glory and might, now and forever, for ages of ages. Amen.”
Source
407
A.D.
John Chrysostom Patristic
A.D. 347–407
“Grief is often capable of refreshing distressed souls and of rendering a burdened conscience light: consider how often women, when they have lost their most beloved children, break their hearts and perish if they are forbidden to mourn and to shed tears. But if they do all which those who are sad are apt to do, they are relieved and receive consolation. And what wonder that this should be the case with women, when you may even see a prophet affected in a similar manner? Therefore he was continually saying, "Leave me alone. I will weep bitterly. Do not try to comfort me over the destruction of the daughter of my people." So oftentimes sadness is the bearer of consolation; and if it is so with regard to this world, much more with regard to spiritual things.”
Source
“It is, after all, the practice of the prophets and the just to grieve not only for themselves but also for the rest of humankind.”

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
“Leave Me alone (שְׁעוּ מִנִּי). Leave Me alone. So says the Holy One, blessed be He, to the ministering angels.”
1167
A.D.
Ibn Ezra Jewish
1089–1167
“Therefore said I. The first person refers to the prophet. שעו ממני Look away from me. Root שעה to let loose, to turn away; comp. תשעה Thou wilt depart (Job 7:19). אמרר בבכי I will embitter by weeping. I will embitter those that listen.”
1256
A.D.
Thomas Aquinas Catholic
1225–1274
“The burden of the valley. Here he threatens against those who were joined to the people of God by right of leadership, and yet despoiled it of its goods: and first as regards those to whom leadership pertained in temporal matters; second, against those to whom it pertained in spiritual matters: "thus says the Lord." Now leadership in temporal matters pertained to kings: and therefore in the first part he threatens against Jerusalem, which was the seat of the kingdom; and concerning this he does two things. First the title is set down, "valley," that is, Jerusalem — not on account of the location's site, since it is on a mountain, but on account of vileness, because to it, as to a valley, filth flowed together from every side, while it followed the practice of the neighboring nations. Ezek. 5: "This is Jerusalem; I have set her in the midst of the nations." Or it is called a valley on account of the lowest part of the city, which was handed over by Shebna to Sennacherib. "Of vision," on account of the holiness of the temple: for in it visions were made to the prophets by the Lord; or on account of the eminence of the place, because it could be seen from afar; or on account of the name which Abraham gave to that place, as is said in Gen. 22: "and he called the name of that place, On the mountain the Lord will see." Second, the threat itself is set down; and concerning this he does three things. First he charges the fault; second he threatens the punishment: "and your slain"; third he shows, within the punishment itself, the persistence of obstinacy: "and you gathered together." Concerning the first he does two things. First he charges a twofold sin. Of idolatry: "what ails you then, that you have gone up to the housetops" — to sacrifice to idols — and you, who rejoiced in the special act of a holy privilege? Hosea 4: "If you play the harlot, Israel, let not Judah at least offend." And the sin of strife: "full of clamor." Above, 5: "I looked that it should bring forth grapes, and it brought forth wild grapes." Second, to aggravate the sin, a twofold benefit of God is set down: namely of the multitude of men, "a populous city": Lam. 1: "How does the city sit solitary, that was full of people?" And of the fullness of joys, "an exulting city," once, in the time of Solomon, on account of excessive prosperity. Ps. 47: "is founded with the exultation of the whole." "Slain." Here he sets down the punishment: and first he threatens the destruction of men as regards those besieged who died of famine: not slain by the sword, but by famine and thirst. Lam. 4: "It was better for those slain by the sword than by famine." As regards the fugitive princes, namely those who were seized and bound, as is read in Jeremiah, last chapter: "all the princes." Lam. 1: "the princes have become like rams that find no pasture." As regards those seized in the city, who were likewise taken captive: "all who were found," "afar off" — into a distant land, led into captivity. Deut. 28: "The Lord will lead into a distant nation." Second, he sets down the prophet's inconsolable compassion: "depart" — you consoling prophets — "do not press upon me," in the manner of those who console. Jer. 9: "Who will give water to my head, and to my eyes a fountain of tears, that I may weep for the slain of my people?" Third, he sets down the manner and order of the punishment: "a day of slaughter"; and concerning this he sets down three things. First, God's indignation: "a day of slaughter" impends. "Searching" — causing a search to be made by the enemies; "magnificent" — making the enemies magnificent: for they trusted in mountains and walls. Zeph. 1: "At that time he will search Jerusalem with lamps, and I will visit upon the men who are settled on their lees." Second, he sets down the overpowering by the enemies: "and Elam" — a city of Persia, from which fighters came with Nebuchadnezzar, who held the monarchy of the East. "The shield," borne against Jerusalem, "has laid bare the wall," on which it had been hung for the adornment of the house. Jer. 46: "Prepare shield and buckler." Or otherwise: "the shield" — the power of the Chaldean — "has laid bare the wall" of the temple of the gold with which it was clothed. Third, he sets down the infliction of loss as regards four things. First as regards the devastation of possessions. "They shall be choice; of chariots" — of Babylon. Jer. 49: "Why do you glory in the valleys? Your valley has flowed away, delicate daughter." Second, as regards the capture of the cities: "horsemen at the gate," lest anyone escape. Jer. 39: "All the princes of Babylon entered, and sat in the middle gate." Third, as regards the profanation of holy things: "and it shall be uncovered" — it shall be laid bare — "the covering," that is, the holy things previously covered, which it was lawful for none but the priest to see. Lam. 1: "The nations have seen your shame." Fourth, as regards the destruction of the armory: "you will see the armory" — that is, the house of the forest, in which weapons were stored — overthrown; concerning the building of which, 3 Kings 7. "Of the city of David," most strong; or Jerusalem itself, with a strong wall in many places. Cant. 4: "The tower of David is built with bulwarks." "And you gathered the waters." Here he sets down the persistence of obstinacy: and first he charges the fault of obstinacy; second he sets forth against them the divine sentence: "and it has been revealed." Now their obstinacy is charged as regards two things. First, as regards the divine help which they did not invoke, trusting in their own strength and ingenuity: "you gathered" — into one place within the city, through hidden channels — "the waters of the lower pool," which had waters flowing from the earth, which, however, could be cut off by the enemies. "You numbered," so that the water might be dispensed by number and measure; "you destroyed the houses" which were next to the wall, so that they would not hinder the defenders; "a reservoir," of the lower pool, "you made," "to flow" between the two walls with which the city was girded; and the water — namely, you restored it; "him" — that is, God; "her" — the water. Ps. 13: "They did not call upon God." Second, as regards the divine counsel, which they despised: "and he will call." And concerning this he sets down three things. First, the counsel itself: "to weeping" — of the eyes; "to mourning" — of the hands; "to baldness," according to the ancient custom, by which they performed these actions in sorrow. Joel 2: "Turn to me with all your heart, in fasting, and weeping, and mourning." Second, he sets down the contempt of the counsel: "and behold joy" — above, 6: "the harp and the lyre are in your feasts." Third, the spirit of contempt: "let us eat." 1 Cor. 15. Wisdom 2: "for our time is the passing of a shadow." "And it has been revealed." Here the sentence is set down; and it can be read as from the person of the Lord: "this blasphemy of yours has been revealed" — that is, I have heard it. "If it shall be forgiven": as if he were to say, do not believe it — above, 2: "therefore do not forgive." Or from the person of the prophet: "this is the voice of the Lord" that has been revealed. And all these things that have been said pertain to the captivity brought about under the rule of Nebuchadnezzar. "Thus says the Lord." Here the threat is set down against those to whom leadership in spiritual matters pertained: and first against the priest who then was; second against the whole priestly order: "in that day, says the Lord." Concerning the first he does two things. First he foretells the deposing of him who, struck with terror, handed over the city to Sennacherib — that is, the lower part; second, the substitution of another: "and it shall come to pass in that day." Concerning the first he does three things. First he describes the person by his office: "who dwells in the tabernacle." It belonged to the priest to keep watch in the tabernacle, as is found in Num. 1. "Set over" — supreme over ten. Second he charges a threefold fault: of unworthy habitation: "what are you doing here" in my house, unworthy of such a habitation? Jer. 11: "What is it that my beloved has done many wicked things in my house?" Of proud presumption concerning himself: "or as who are you here?" Do you esteem yourself as if you were of some worth, when you are nothing? Zech. 11: "O shepherd, and idol." Of the curious building of a sepulcher: "you have hewn out," here in Jerusalem next to the temple, "a memorial," that is, an epitaph, "in a high place," that is, in the loftiest site of the sepulcher; or literally, he had placed his sepulcher in a high place for his own memory, as is found in 1 Macc. 13. Third he threatens the punishment: "behold, the Lord" — threefold: first, of captivity, just as one is carried off — bound, and without labor — a cock, one that rears chicks in the manner of a hen, being castrated, which they call capons; and, as a garment, lightly lifted upon the shoulder. Jer. 20: "You, Pashhur, and all the inhabitants of your house, shall go into captivity, and you shall come into Babylon, and there you shall die, and there you shall be buried, you and all your friends." Second, of confusion: "crowning" — that is, in place of the crown which you used in the pontifical rite, you will have tribulation, like a ball, which finds no lofty resting-place. "The chariots of your glory," in which you were borne gloriously, turned into your confusion. "And the shame of the house of the Lord"; that is, the glory which you had in the house of the Lord will be turned for you into shame. Hosea 4: "I will change their glory into shame." Third, the punishment of deposition: "and I will drive out." 3 Kings 2: "Solomon therefore cast out Abiathar, that he should not be priest of the Lord." "And it shall be." Here he sets down the substitution of another; and concerning this he sets down three things. The election: "I will call" — one of the twenty-four, as is read in 1 Chron. 25; 1 Kings 2: "I will raise up for myself a faithful priest, who shall be according to my heart." Second, his consecration: "and I will clothe him"; for he was consecrated with the pontifical vestments, as is clear from Lev. 18 concerning these vestments, and Exod. 28. Third, he confers jurisdiction: "and power." And first as regards the power which he had over the people, setting down the power: "and the power" — namely, "I will give." Ps. 108: "Let his days be few, and let another take his office." "And he shall be as a father." Jer. 3: "I will give you shepherds according to my own heart, and they shall feed you with knowledge and doctrine." Second, as regards the power which he had over the temple: "and the key," which was golden, "of the house of David," that is, of the temple, for the building of which David prepared the expenses, as is clear at the end of 1 Chron.; "upon his shoulder," that is, his own governance; or because he used it as a kind of ornament. "He shall open," because it was lawful for him to enter once a year into the holy of holies, as is said in Heb. 9. Third, as regards the power which he had over the whole order of ministers: "and I will fasten him as a peg" — a diminutive from "pole"; for just as various vessels are hung upon some pole, so various offices, which have the use of various vessels in the ministries of the house of the Lord, pertained to his charge: "in the place of the faithful," namely, the temple. Concerning this power it is spoken of in Numbers 3 and 4. "In that day." Here he speaks against the whole priesthood, which was destroyed in the time of Zedekiah, when Nebuchadnezzar took captive. For the things that were said about Shebna pertain to the time of Sennacherib. And here "the peg" is called the priesthood itself, which ceased at the time of the captivity. Hosea 3: "The children of Israel shall sit many days without king, and without prince, and without sacrifice, and without altar, and without ephod, and without teraphim." Note, upon that word "who dwells in the tabernacle," that the tabernacle is manifold. The first, of carnal concupiscence, which is that of swine. Heb., last chapter: "We have an altar, from which they have no right to eat who serve the tabernacle." The second is of temporal and natural life, which is that of men. 2 Pet. 1: "For I am certain that the putting off of my tabernacle is swift." The third is of the Church militant, which is that of those who fight. Above, 4: "It shall be a tabernacle for a shade in the daytime from the heat." The fourth is of contemplative wisdom, which is that of those who rest. Ps. 131: "We will go into his tabernacle." The fifth is of the eternal vision, or the heavenly homeland: which is that of all the blessed. Below, 33: "Your eyes shall see Jerusalem, a wealthy city, a tabernacle that can never be removed."”

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“Therefore said I,.... Not God to the ministering angels, as Jarchi; but the prophet to those that were about him, his relations, friends, and acquaintance: look away from me; turn away from me, look another way; cease from me, let me alone; leave me to myself, that I may weep in secret, take my fill of sorrow, and give full vent to it: I will weep bitterly; or, "I will be bitter", or, "bitter myself in weeping" (n); it denotes the vehemence of his grief, the greatness of his sorrow, and the strength of his passion: labour not to comfort me; make use of no arguments to persuade me to lay aside my mourning; do not be urgent and importunate with me to receive consolation, for my soul refuses to be comforted: because of the spoiling of the daughter of my people; his countrymen, which were as dear to him as a daughter to a tender parent, now spoiled, plundered, and made desolate by the ravages of the enemy, in many cities of Judea. (n) "amarificabo me in fletu", Montanus; "amaritudine afficiam me in isto fletu", Junius & Tremellius.”
Source
1849
A.D.
1774–1849
“People. He saw this in spirit, though he might not live to witness it. (Calmet)”
1871
A.D.
1871
“Look . . . from me--Deep grief seeks to be alone; while others feast joyously, Isaiah mourns in prospect of the disaster coming on Jerusalem (Mic 1:8-9). daughter, &c.--(see on Isa 1:8; Lam 2:11).”
1875
A.D.
Keil & Delitzsch Lutheran
1861–1875
“"Therefore I say, Look away from me, that I may weep bitterly; press me not with consolations for the destruction of the daughter of my people! For a day of noise, and of treading down, and of confusion, cometh from the Lord, Jehovah of hosts, in the valley of vision, breaking down walls; and a cry of woe echoes against the mountains." The note struck by Isaiah here is the note of the kinah that is continued in the Lamentations of Jeremiah. Jeremiah says sheber for shod (Lam 3:48), and bath-ammi (daughter of my people) is varied with batḣZion (daughter of Zion) and bath-yehudah (daughter of Judah). Mērēr babbeci (weep bitterly) is more than bâcâh mar (Isa 33:7): it signifies to give one's self thoroughly up to bitter weeping, to exhaust one's self with weeping. The two similar sounds which occur in Isa 22:5, in imitation of echoes, can hardly be translated. The day of divine judgment is called a day in which masses of men crowd together with great noise (mehūmâh), in which Jerusalem and its inhabitants are trodden down by foes (mebūsâh) and are thrown into wild confusion (mebūcâh). This is one play upon words. The other makes the crashing of the walls audible, as they are hurled down by the siege-artillery (mekarkar kir). Kirkēr is not a denom. of kı̄r, as Kimchi and Ewald suppose (unwalling walls), but is to be explained in accordance with Num 24:17, "he undermines," i.e., throws down by removing the supports, in other words, "to the very foundations" (kur, to dig, hence karkârâh, the bottom of a vessel, Kelim ii. 2; kurkoreth, the bottom of a net, ib. xxviii. 10, or of a cask, Ahaloth ix. 16). When this takes place, then a cry of woe echoes against the mountain (shōa‛, like shūa‛, sheva‛), i.e., strikes against the mountains that surround Jerusalem, and is echoed back again. Knobel understands it as signifying a cry for help addressed to the mountain where Jehovah dwells; but this feature is altogether unsuitable to the God - forgetting worldly state in which Jerusalem is found. It is also to be observed, in opposition to Knobel, that the description does not move on in the same natural and literal way as in a historical narrative. The prophet is not relating, but looking; and in Isa 22:5 he depicts the day of Jehovah according to both its ultimate intention and its ultimate result.”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.