The interpretation timeline
Isaiah 49:4 Douay-Rheims

And I said: I have laboured in vain, I have spent my strength without cause and in vain: therefore my judgment is with the Lord, and my work with my God.

1105 – 1875 7 witnesses

Scholastic

c. 1100 – 1500
1105
A.D.
Rashi Jewish
1040–1105
“And I said, I toiled in vain when I saw that I admonish them and they do not obey. Yet surely my right is with the Lord He knows that it is not from me but from them [i.e., He knows that their failure to obey is not due to my laziness, but to their obstinacy].”
1167
A.D.
Ibn Ezra Jewish
1089–1167
“Then I said. Then I, the prophet, said. I said to myself, I have laboured in vain. I have troubled myself in vain to rebuke Israel; they do not hearken. My judgment is with God. He will reward me for my trouble. ופעלתי And my wages. Comp. שביר פעלת the wages of one that is hired (Lev. 19:13)”
1256
A.D.
Thomas Aquinas Catholic
1225–1274
“Hear, O islands, etc. In this part he pursues the order of the liberation more specifically; and concerning this he does two things. First the people confesses the benefits received; second it receives the promise of things to come, there, I said: in vain, etc. Concerning the first, four benefits are confessed. First, the privilege of the divine election; and it continues why the prophet had above enjoined the people, that they should announce it. Whence immediately is subjoined the voice of the people announcing, and saying, Hear. From the womb, choosing me in the fathers themselves. Ps. 21: From the womb of my mother, God, etc. Second, the efficacy of prayer: and he set the mouth, prayer, as a sword, penetrating even to the ears of God and the depths of his mercy, Eph. ult.: the sword of the spirit, etc. Third, the help of divine protection: in the shadow, that is, under the protection of his power, as an archer hides a chosen arrow, to preserve it. Ps. 16: under the shadow of thy wings, etc.; Ps. 26: he hath hidden me in his tabernacle, etc. Fourth, the glory of the divine power: and he said to me: in thee will I glory; through the great things shown in thee I will appear glorious. Above, 43: every one that calleth upon my name, etc. According to others, this is the voice of Cyrus, whose name was foretold by Isaiah above, 45, before he was born; whose threatening words were as a sword, and he was protected lest his grandfather should kill him, and was kept as a chosen arrow for the appointed time; to whom it was announced that the people of Israel was the servant of God. Otherwise it is expounded of Christ; whose name was foretold by the Angel; the word of preaching, a sword piercing hearts; protected, on account of the weakness of the flesh, by the power of the divinity, and chosen among all for the fulfilling of the salvation of the human race. And he is called Israel, because he was born of the people of Israel according to the flesh. I said: here the Lord promises future benefits: and first he promises the prophet Isaiah exaltation; second, to the people liberation, there, thus saith the Lord the redeemer, etc. Concerning the first, two things. First is set down the allegation of the prophet, setting forth his labor in preaching, although through the fault of the hearers no fruit followed: and he concludes: therefore my judgment, on my behalf, is with the Lord, before him, and my work, as pleasing to him. Jer. 6: the founder hath melted in vain, etc. Second, he sets down God's response: and now thus saith the Lord: and first is signified the acceptance of the allegation, that I may bring back, as if to say: choosing me from the womb of my mother for this, that I might recall his people to him. And yet Israel shall not altogether be gathered, to him through my preaching. And yet I am glorified, etc.; Habac. 3: God, the Lord, is my strength, etc. Second, the response itself is set down, and he said: it is a small thing, as if to say: so greatly will I honor thy ministry that not only among the Jews, but among all the nations, my salvation shall be announced through thee. Rom. 3: is he the God of the Jews only? etc. This too is plainly expounded of Christ, who by his preaching and the consummation of his death made little fruit among the Jews, but enlightened and saved the nations. Likewise also of Cyrus, though more forcedly, who through his kindnesses, according to the Lord's intention, recalled the people to the worship of God, and yet did not succeed, to whom dominion over many nations was given by God. Thus saith the Lord the redeemer, etc. Here he promises liberation: and concerning this he does two things. First he promises liberation; second he excludes their doubt, there, and Sion said, etc. Concerning the first, three things. First, the things preceding liberation, namely the veneration of the Jews, which was the cause of the liberation; recalling their former contempt: contemptible, on account of the people's weakness; abominable, on account of the singularity of their worship; a servant, on account of subjection to diverse nations, above, 18: to a nation rent asunder, etc.; and he sets down the veneration itself: kings shall see the great things I will show for thee, and shall adore, as, according to the letter, Nabuchodonosor, Dan. 2, and Cyrus, and his other princes honored Esdras. Another preamble is the exaltation of the liberating king, namely Cyrus: in an acceptable time, and he does not determine the time of the exaltation: acceptable, when it shall please me to save my people, I have heard, exalting thee into a kingdom, according to thy desire, and the fruit of the exaltation: and I have preserved, etc., for the fulfilling of the covenant of my people. Be revealed, that is, be enlightened. Or of Christ, who in his passion was despised, and judged as it were a servant. Below, 53: we saw him despised, etc., but afterward, according to the letter, adored by kings. Ps. 71: all kings shall adore him, etc.; in an acceptable time, namely the time of grace. 2 Cor. 6: behold, now is the time, etc. Second, he sets down the things consequent upon the liberation, promising to the liberated an abundance of good things: they shall feed in the ways; that is, they shall enjoy consolations as abundantly as sheep enjoy pastures, when they are found even in the way, beyond the usual. Ezech. 34: they shall rest in the grass, etc.; as to the absence of evils, both of want, he shall not hunger, etc., and of harm inflicted, the heat, of tribulation; and the sun, the tyrant causing it. Ps. 120: the sun shall not burn by day, etc.; and he assigns the cause of both. Because he that is merciful, etc.; of waters, of consolations. Ps. 22: the Lord ruleth me. Third, he promises the liberation itself, setting down the preparation of the ways: and I will make all the mountains; that is, the princes will help you to return. Above, 40: every valley shall be filled, etc.; setting down also the return of the captives: behold these from afar, from the east, the sea, the west. Jer. 31: I will bring them from the north, etc.; he sets down also the giving of thanks: praise, ye heavens, etc.; Ps. 68: let the heavens praise him, etc. And Sion said, etc. Here he excludes their doubt: and first that which arose from the divine indignation; second that which arose from their dejection, there, and thou shalt say in the heart, etc.; third that which arose from the power of the enemies, there, shall it be taken away, etc. Concerning the first, two things. First he sets down the doubt: hath forsaken, without help; and therefore I cannot hope for liberation. Baruch 4: I am forsaken, etc.; second he excludes it by the likeness of a mother: is it possible, etc.; Jer. 31: if a son honorable, etc.; third he applies the promise concerning the restoration of the city: and first as to the rebuilding of the walls, setting down the divine purpose: behold, in my hands; as if to say: thus I hold thee in memory, as one who writes, or makes some sign on his hand, that he may be mindful of some thing. Thy walls; as if to say, now I see the rebuilding of thy walls. Job 37: he hideth in the hands, etc.; Ps. 89: a thousand years before the eyes, etc.; and the manner of the fulfillment: builders have come, that is, rebuilders, namely Zorobabel, and Jesus, and others, already in my eyes; the scatterers, the Chaldeans. Zach. 4: the hands of Zorobabel, etc. Second, as to the habitation of men: and concerning this he does three things. First, the gathering together of the citizens: lift up round about, etc.; Baruch 4: look about, Jerusalem, etc. Second, the re-inhabiting of the city, showing that it shall be inhabited. As I live, the manner of an oath; as with an ornament — as a bride with garments, so the city is adorned with citizens. Below, 61: he hath clothed me with the garment of salvation, etc.; showing that it shall be filled with inhabitants: for the desert places, as to inhabitants, the solitudes, as to the tillers, the ruins, as to the destroyed walls. Zach. 2: it shall be inhabited without a wall, etc.; he shows also that it shall be emptied of enemies: and far, etc. Third, he foretells the multitude of the inhabitants: still shall the children of sterility say, that is, those who were born when thou didst believe thyself barren, emptied of inhabitants. Below, 54: enlarge the place of the tent, etc. And thou shalt say in the heart, etc. Here he excludes the second doubt: and first he sets down the wonder, and thou shalt say, out of wonder: barren, because there were not in me men who could beget children; destitute, of divine help. Below, 66: who hath ever heard such, etc. Second he excludes the doubt, setting down the manner of the multitude of the inhabitants: thus saith the Lord: as to four things. First, as to the divine inspiration: behold I will lift up the hand, as it were making a sign; above, 11: he shall lift up a sign among the nations, etc. Second, as to the honorable bringing back: and they shall bring in the arms, in which is signified the help which they had from the nations. Kings, foster-fathers, providing for thee in necessities. Baruch 5: the Lord will bring them to thee, etc. Third, as to the exaltation of the liberated: with the face to the earth, this especially at the time of the Machabees; below, 40: they shall come to thee bowed down, etc. Fourth, he assigns the reason for this: and thou shalt know that I, etc.; Ps. 70: in thee, O Lord, have I hoped, let me not be confounded, etc. Shall it be taken away. Here he excludes the third doubt: and first he sets it down, from the strong, Nabuchodonosor; Matth. 12: or how can one enter, etc. Second he excludes it: for thus he saith, first setting down the benefit of the liberation: the captivity, namely of the Jews. Job 29: I broke the jaws of the wicked one, etc.; second, the manner of the liberation, setting down the destruction of the enemies. But them, namely the Chaldeans, they judged, unjustly. Soph. 3: I will kill, etc.; and he sets down the determination of the punishment: and I will feed: either on account of dissension, as above, 9: every man the flesh of the arm, etc., or on account of the multitude of the dead, while the mouth of one fell upon the blood of another, as if he would drink: or on account of famine. Third, he sets down the fruit of the liberation: and all flesh shall know, etc.; above, 40: all flesh shall see, etc.”

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“Then I said,.... The Messiah said, by way of objection, in a view of what treatment he should meet with, or when entered on his work, and which he found by experience, what follows: I have laboured in vain; this is not to be understood of the travail of his soul, or of his sufferings and death, which were not in vain, but issued in the redemption and salvation of his people; but of his ministry and miracles, and fatiguing journeys among the Jews; which, with respect to them, were in vain, as to their conversion and reformation; they rejecting the Messiah, slighting his doctrines and miracles, refusing to be gathered by him, being a faithless and perverse generation: I have spent my strength for naught, and in vain; by frequent preaching and working of miracles, and travelling from place to place: the same thing is designed as before, repeated in other words, to express the certainty of it, to chew the ingratitude and wickedness of the people, and to utter the complaints of his mind: yet surely my judgment is with the Lord; or is manifest before the Lord, as the Targum; the Lord knew that he had called him to his office; how prudently, diligently, and faithfully he had executed it; and what was his right and due, and which would be given him; and with this he corrects his former complaint, and makes himself easy, and quiets and satisfies his mind: and my work with my God; or the reward of my works is before my God, as the Targum; and before himself also, Isa 40:10 as his work was assigned him by the Lord, so his reward was promised him, and which he knew he should have; and having done his work, be asked for his reward, and had it, Joh 17:4.”
Source
1849
A.D.
1774–1849
“God. He will reward the labours of his ministers, though the people be obstinate. The prophets and our Saviour frequently complain, chap. lxv. 2., and Mark ix. 18.”
1871
A.D.
1871
“I--Messiah. in vain--comparatively in the case of the greater number of His own countrymen. "He came unto His own, and His own received Him not" (Isa 53:1-3; Luk 19:14; Joh 1:11; Joh 7:5). Only a hundred twenty disciples met after His personal ministry was ended (Act 1:15). yet . . . my judgment . . . with the Lord--Ultimately, God will do justice to My cause, and reward (Margin for "work," compare Isa 40:10; Isa 62:11) My labors and sufferings. He was never "discouraged" (Isa 42:4; Isa 50:7, Isa 50:10). He calmly, in spite of seeming ill success for the time, left the result with God, confident of final triumph (Isa 53:10-12; Pe1 2:23). So the ministers of Christ (Co1 4:1-5; Pe1 4:19).”
Source
1875
A.D.
Keil & Delitzsch Lutheran
1861–1875
“In the next v. the speaker meets the words of divine calling and promise with a complaint, which immediately silences itself, however. "And I, I said, I have wearied myself in vain, and thrown away my strength for nothing and to no purpose; yet my right is with Jehovah, and my reward with my God." The Vav with which the v. opens introduces the apparent discrepancy between the calling he had received, and the apparent failure of his work. אכן, however, denotes the conclusion which might be drawn from this, that there was neither reality nor truth in his call. The relation between the clauses is exactly the same as that in Psa 31:23 and Jon 2:5 (where we find אך, which is more rarely used in this adversative sense); compare also Psa 30:7 (but I said), and the psalm of Hezekiah in Isa 38:10 with the antithesis in Psa 38:15. In the midst of his activity no fruit was to be seen, and the thought came upon him, that it was a failure; but this disturbance of his rejoicing in his calling was soon quieted in the confident assurance that his mishpât (i.e., his good right in opposition to all contradiction and resistance) and his "work" (i.e., the result and fruit of the work, which is apparently in vain) are with Jehovah, and laid up with Him until the time when He will vindicate His servant's right, and crown his labour with success. We must not allow ourselves to be led astray by such parallels as Isa 40:10; Isa 62:11. The words are not spoken in a collective capacity any more than in the former part of the verse; the lamentation of Israel as a people, in Isa 40:27, is expressed very differently.”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.