The interpretation timeline
Luke 17:22 Douay-Rheims

And he said to his disciples: The days will come, when you shall desire to see one day of the Son of man; and you shall not see it.

A.D. 339 – 1871 9 witnesses

Patristic

before A.D. 750
339
A.D.
c. A.D. 260–339
“As if he said, If at the coming of Antichrist, his fame shall be spread abroad, as though Christ had appeared, go not out, nor follow him. For it cannot be that He who was once seen on earth, shall any more dwell in the corners of the earth. It will therefore be he of whom we speak, not the true Christ. For this is the clear sign of the second coming of our Saviour, that suddenly the lustre of His coming shall fill the whole world; and so it follows, For as the lightning that lighteneth, &c. For He will not appear walking upon the earth, as any common man, but will illuminate our whole universe, manifesting to all men the radiance of His divinity.”
Source
444
A.D.
A.D. 376–444
“When our Lord said, The kingdom of God is within you, He would fain prepare His disciples for suffering, that being made strong they might be able to enter the kingdom of God; He therefore foretells to them, that before His coming from heaven at the end of the world, persecution will break out upon them. Hence it follows, And he said unto the disciples, The days will come, &c. meaning that so terrible will be the persecution, that they would desire to see one of His days, that is, of that time when they yet walked with Christ. Truly the Jews ofttimes beset Christ with reproaches and insults, and sought to stone Him, and ofttimes would have hurled Him down from the mountain; but even these seem to be looked upon as slight in comparison of greater evils that are to come.”
Source
735
A.D.
Bede the Venerable Patristic
c. A.D. 672–735
“Or, by the day of Christ He signifies His kingdom, which we hope will come, and He rightly says, one day, because there shall no darkness disturb the glory of that blessed time. It is right then to long for the day of Christ, yet from the earnestness of our longing, let us not vision to ourselves as though the day were at hand. Hence it follows, And they shall say to you, Lo here! and, Lo there!”
Source

Scholastic

c. 1100 – 1500
1107
A.D.
c. 1055–1107
“For their life was then without trouble, for Christ took care of them and protected them. But the time was coming when Christ should be taken away, and they should be exposed to perils, being brought before kings and princes, and then they should long for the first time and its tranquillity.”

Reformation

c. 1500 – 1650
1637
A.D.
1567–1637
“And He said unto His disciples , The days will come. That is, the time will come and is now at hand, when for My faith and the preaching of the gospel you will suffer many adversities, persecutions, and distresses ; the errors and heresies, moreover, of the Digitized by Google 432 innovators ; and be oppressed by straits of body and mind, and know not what consolation or counsel to take. Hence you shall seek to see Me, and to consult Me, if only once, but in vain : for after I shall have ascended into heaven, I shall no more appear on earth. Thus the things you now hear from Me you ought to teach, and to console, and to direct, until, at my second coming to judgment, I return to you, that is, to your successors. Thus He spoke to warn them that they could only come to the kingdom of glory through tribulations, that they might neither fail in heart nor fall from the faith. So Theophylact, Euthymius, Titus, Bede, and others”
Source

Post-Reformation

c. 1650 – 1900
1771
A.D.
John Gill Reformed
1697–1771
“And they shall say unto you, see here, or see there,.... That is, there is Christ; and in two of Beza's exemplars, the word Christ is added as in Mat 24:23 from whence it seems to be transcribed: and the sense is, it shall be said by one or another; Christ is in such a place, or he is in such a place, and he will quickly appear, and deliver the people of the Jews out of all their distresses and calamities by the Romans, Go not after them nor follow them: the last clause, "nor follow them", is left out in the Syriac and Persic versions; the meaning is, give no credit to them; as if Christ was come again in person, and was in such a place, do not go along with them, where they direct, as into the desert, or into the secret chambers; for to follow them will be very dangerous, of bad consequence, as well as vain and fruitless; see Act 5:36.”
Source
1832
A.D.
Adam Clarke Methodist
1762–1832
“When ye shall desire to see one of the days - As it was our Lord's constant custom to support and comfort the minds of his disciples, we cannot suppose that he intimates here that they shall be left destitute of those blessings necessary for their support in a day of trial. When he says, Ye shall desire to see one of the days of the Son of man, he either means, ye of this nation, ye Jews, and addresses his disciples as if they should bear witness to the truth of the declaration; intimating that heavy calamities were about to fall upon them, and that they should desire in vain to have those opportunities of returning to God which now they rejected; or, he means that such should the distressed state of this people be, that the disciples would through pity and tenderness desire the removal of those punishments from them, which could not be removed because the cup of their iniquity was full. But the former is more likely to be the sense of the place.”
Source
1849
A.D.
1774–1849
“To see one day, &c. Hereafter, when I shall be no longer visibly among you, you shall heartily wish for one day’s conversation with me. (Witham) — This verse is addressed to the disciples. He insinuates that he will take from them this corporeal presence, and they shall be exposed to persecution and affliction: then they shall wish to see one day of the Son of man, and shall not be able to obtain it. They shall wish ardently to see him, to entertain themselves with him, and consult him, but shall not have that happiness. This was meant to excite the disciples to profit more of his presence whilst they enjoyed it. (Calmet)”
Source
1871
A.D.
1871
“The days--rather "Days." will come--as in Luk 19:43, when, amidst calamities, &c., you will anxiously look for a deliverer, and deceivers will put themselves forward in this character. one of the days of the Son of man--Himself again among them but for one day; as we say when all seems to be going wrong and the one person who could keep them right is removed [NEANDER in STIER, &c.]. "This is said to guard against the mistake of supposing that His visible presence would accompany the manifestation and establishment of His kingdom" [WEBSTER and WILKINSON].”
Source
Modern · 1953 →

The in-app commentary runs from the Fathers to the early-modern record, then stops — that's where the public-domain sources end, not where the reading does. For the modern reading, follow the sources directly.